Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Systematic Review Article

Associations of Yersinia Enterocolitica Infection with Autoimmune Thyroid Diseases: A Systematic Review and Meta-Analysis

Author(s): Moein Zangiabadian, Mehdi Mirsaeidi, Mohammad H. Pooyafar, Mehdi Goudarzi and Mohammad J. Nasiri*

Volume 21, Issue 4, 2021

Published on: 21 June, 2020

Page: [682 - 687] Pages: 6

DOI: 10.2174/1871530320666200621180515

Price: $65

Abstract

Introduction: Yersinia enterocolitica infection is reportedly associated with the development of autoimmune thyroid diseases (AITD). However, evidence that such infection can lead to AITD is controversial. Thus, this study was aimed to investigate the associations of Y. enterocolitica infection with AITD.

Methods: A meta-analysis was performed using PubMed, Web of Science, Embase and Cochrane library to identify relevant studies. The odds ratios (OR) and associated 95% confidence intervals [CI] were obtained. Data were analyzed by STATA 13.0 (Stata Corporation, College Station, TX, USA).

Results: Of 215 articles identified, 8 studies with a total of 1490 participants met the criteria and were included in the meta-analysis. There was a significant association between Y. enterocolitica positivity and AITD (OR: 4.31 [CI 95%: 1.81–10.07], P-value: 0.00). According to the subgroup analysis, Y. enterocolitica infection statistically increased the risk of Graves' disease (GD) (OR: 6.12, [CI 95%: 3.71-10.10], P-value: 0.00). Likewise, the pooled OR of association between Y. enterocolitica positivity and hashimoto’s thyroiditis (HT) was 2.84 (CI 95%: 0.71-11.25, P-value: 0.1).

Conclusion: The current studies suggest that Y. enterocolitica may be associated with the development of AITD. Further study is needed to explore the underlying mechanisms.

Keywords: Yersinia enterocolitica, autoimmune thyroid diseases, Graves' disease, hashimoto's thyroiditis, meta-analysis, thyroid dysfunction.

« Previous Next »
[1]
Strieder, T.G.; Wenzel, B.E.; Prummel, M.F.; Tijssen, J.G.; Wiersinga, W.M. Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease. Clin. Exp. Immunol., 2003, 132(2), 278-282.
[http://dx.doi.org/10.1046/j.1365-2249.2003.02139.x] [PMID: 12699417]
[2]
Antonelli, A.; Ferrari, S.M.; Corrado, A.; Di Domenicantonio, A.; Fallahi, P. Autoimmune thyroid disorders. Autoimmun. Rev., 2015, 14(2), 174-180.
[http://dx.doi.org/10.1016/j.autrev.2014.10.016] [PMID: 25461470]
[3]
Ferrari, S.M.; Fallahi, P.; Antonelli, A.; Benvenga, S. Environmental issues in thyroid diseases. Front. Endocrinol. (Lausanne), 2017, 8, 50.
[http://dx.doi.org/10.3389/fendo.2017.00050] [PMID: 28373861]
[4]
Cui, Z.; Wang, Z.; Liu, X.; Cai, Y.; Xu, X.; Yang, T. Establishment of clinical diagnosis model of Graves’ disease and Hashimoto’s thyroiditis. J. Transl. Med., 2019, 17(1), 11.
[http://dx.doi.org/10.1186/s12967-018-1765-3] [PMID: 30616573]
[5]
Lee, H.J.; Li, C.W.; Hammerstad, S.S.; Stefan, M.; Tomer, Y. Immunogenetics of autoimmune thyroid diseases: a comprehensive review. J. Autoimmun., 2015, 64, 82-90.
[http://dx.doi.org/10.1016/j.jaut.2015.07.009] [PMID: 26235382]
[6]
Diana, T.; Krause, J.; Olivo, P.D.; König, J.; Kanitz, M.; Decallonne, B.; Kahaly, G.J. Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease. Clin. Exp. Immunol., 2017, 189(3), 304-309.
[http://dx.doi.org/10.1111/cei.12980] [PMID: 28439882]
[7]
Tomer, Y. Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu. Rev. Pathol., 2014, 9, 147-156.
[http://dx.doi.org/10.1146/annurev-pathol-012513-104713] [PMID: 24460189]
[8]
Ai, J.; Leonhardt, J.M.; Heymann, W.R. Autoimmune thyroid diseases: etiology, pathogenesis, and dermatologic manifestations. J. Am. Acad. Dermatol., 2003, 48(5), 641-659.
[http://dx.doi.org/10.1067/mjd.2003.257] [PMID: 12734493]
[9]
Stassi, G.; De Maria, R. Autoimmune thyroid disease: new models of cell death in autoimmunity. Nat. Rev. Immunol., 2002, 2(3), 195-204.
[http://dx.doi.org/10.1038/nri750] [PMID: 11913070]
[10]
Tomer, Y.; Huber, A. The etiology of autoimmune thyroid disease: a story of genes and environment. J. Autoimmun., 2009, 32(3-4), 231-239.
[http://dx.doi.org/10.1016/j.jaut.2009.02.007] [PMID: 19307103]
[11]
Jacobson, E.M.; Tomer, Y. The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. J. Autoimmun., 2007, 28(2-3), 85-98.
[http://dx.doi.org/10.1016/j.jaut.2007.02.006] [PMID: 17369021]
[12]
Jacobson, E.M.; Huber, A.; Tomer, Y. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. J. Autoimmun., 2008, 30(1-2), 58-62.
[http://dx.doi.org/10.1016/j.jaut.2007.11.010] [PMID: 18178059]
[13]
Ermann, J.; Fathman, C.G. Autoimmune diseases: genes, bugs and failed regulation. Nat. Immunol., 2001, 2(9), 759-761.
[http://dx.doi.org/10.1038/ni0901-759] [PMID: 11526377]
[14]
Duntas, L.H. Environmental factors and autoimmune thyroiditis. Nat. Clin. Pract. Endocrinol. Metab., 2008, 4(8), 454-460.
[http://dx.doi.org/10.1038/ncpendmet0896] [PMID: 18607401]
[15]
Corapçioğlu, D.; Tonyukuk, V.; Kiyan, M.; Yilmaz, A.E.; Emral, R.; Kamel, N.; Erdoğan, G. Relationship between thyroid autoimmunity and Yersinia enterocolitica antibodies. Thyroid, 2002, 12(7), 613-617.
[http://dx.doi.org/10.1089/105072502320288483] [PMID: 12193307]
[16]
Tozzoli, R.; Barzilai, O.; Ram, M.; Villalta, D.; Bizzaro, N.; Sherer, Y.; Shoenfeld, Y. Infections and autoimmune thyroid diseases: parallel detection of antibodies against pathogens with proteomic technology. Autoimmun. Rev., 2008, 8(2), 112-115.
[http://dx.doi.org/10.1016/j.autrev.2008.07.013] [PMID: 18700170]
[17]
Hargreaves, C.E.; Grasso, M.; Hampe, C.S.; Stenkova, A.; Atkinson, S.; Joshua, G.W.; Wren, B.W.; Buckle, A.M.; Dunn-Walters, D.; Banga, J.P. Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves’ disease. J. Immunol., 2013, 190(11), 5373-5381.
[http://dx.doi.org/10.4049/jimmunol.1203412] [PMID: 23630351]
[18]
Effraimidis, G.; Tijssen, J.G.; Strieder, T.G.; Wiersinga, W.M. No causal relationship between Yersinia enterocolitica infection and autoimmune thyroid disease: evidence from a prospective study. Clin. Exp. Immunol., 2011, 165(1), 38-43.
[http://dx.doi.org/10.1111/j.1365-2249.2011.04399.x] [PMID: 21488870]
[19]
Benvenga, S.; Santarpia, L.; Trimarchi, F.; Guarneri, F. Human thyroid autoantigens and proteins of Yersinia and Borrelia share amino acid sequence homology that includes binding motifs to HLA-DR molecules and T-cell receptor. Thyroid, 2006, 16(3), 225-236.
[http://dx.doi.org/10.1089/thy.2006.16.225] [PMID: 16571084]
[20]
Hansen, P.S.; Wenzel, B.E.; Brix, T.H.; Hegedüs, L. Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study. Clin. Exp. Immunol., 2006, 146(1), 32-38.
[http://dx.doi.org/10.1111/j.1365-2249.2006.03183.x] [PMID: 16968395]
[21]
Arscott, P.; Rosen, E.D.; Koenig, R.J.; Kaplan, M.M.; Ellis, T.; Thompson, N.; Baker, J.R. Jr Immunoreactivity to Yersinia enterocolitica antigens in patients with autoimmune thyroid disease. J. Clin. Endocrinol. Metab., 1992, 75(1), 295-300.
[PMID: 1619022]
[22]
Wenzel, B. Antibodies to plasmid-encoded proteins of enteropathogenic Yersinia in patients with autoimmune thyroid disease. Lancet, 1988¸ 1(8575-8), 56.,
[http://dx.doi.org/10.1016/s0140-6736(88)91034-3 ] [PMID: 2891918]
[23]
Weiss, M.; Ingbar, S.H.; Winblad, S.; Kasper, D.L. Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica. Science, 1983, 219(4590), 1331-1333.
[http://dx.doi.org/10.1126/science.6298936] [PMID: 6298936]
[24]
Luo, G.; Fan, J.L.; Seetharamaiah, G.S.; Desai, R.K.; Dallas, J.S.; Wagle, N.; Doan, R.; Niesel, D.W.; Klimpel, G.R.; Prabhakar, B.S. Immunization of mice with Yersinia enterocolitica leads to the induction of antithyrotropin receptor antibodies. J. Immunol., 1993, 151(2), 922-928.
[PMID: 8335920]
[25]
Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med., 2009, 6(7)e1000097
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[26]
Institute, J.B. Joanna Briggs Institute reviewers’ manual, 2011 edition; Joanna Briggs Institute, 2011.
[27]
Higgins, J.P.; Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med., 2002, 21(11), 1539-1558.
[http://dx.doi.org/10.1002/sim.1186] [PMID: 12111919]
[28]
Begg, C.B.; Mazumdar, M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4), 1088-1101.
[http://dx.doi.org/10.2307/2533446] [PMID: 7786990]
[29]
Shenkman, L.; Bottone, E.J. Antibodies to Yersinia enterocolitica in thyroid disease. Ann. Intern. Med., 1976, 85(6), 735-739.
[http://dx.doi.org/10.7326/0003-4819-85-6-735] [PMID: 1036668]
[30]
Guarneri, F.; Carlotta, D.; Saraceno, G.; Trimarchi, F.; Benvenga, S. Bioinformatics support the possible triggering of autoimmune thyroid diseases by Yersinia enterocolitica outer membrane proteins homologous to the human thyrotropin receptor. Thyroid, 2011, 21(11), 1283-1284.
[http://dx.doi.org/10.1089/thy.2010.0364] [PMID: 21877932]
[31]
Wang, Z.; Zhang, Q.; Lu, J.; Jiang, F.; Zhang, H.; Gao, L.; Zhao, J. Identification of outer membrane porin f protein of Yersinia enterocolitica recognized by antithyrotopin receptor antibodies in Graves’ disease and determination of its epitope using mass spectrometry and bioinformatics tools. J. Clin. Endocrinol. Metab., 2010, 95(8), 4012-4020.
[http://dx.doi.org/10.1210/jc.2009-2184] [PMID: 20484489]
[32]
Giménez-Barcons, M.; Colobran, R.; Gómez-Pau, A.; Marín-Sánchez, A.; Casteràs, A.; Obiols, G.; Abella, R.; Fernández-Doblas, J.; Tonacchera, M.; Lucas-Martín, A.; Pujol-Borrell, R. Graves’ disease TSHR-stimulating antibodies (TSAbs) induce the activation of immature thymocytes: a clue to the riddle of TSAbs generation? J. Immunol., 2015, 194(9), 4199-4206.
[http://dx.doi.org/10.4049/jimmunol.1500183] [PMID: 25801430]
[33]
Stuart, P.M.; Woodward, J.G. Yersinia enterocolitica produces superantigenic activity. J. Immunol., 1992, 148(1), 225-233.
[PMID: 1345786]
[34]
Takuno, H.; Sakata, S.; Miura, K. Antibodies to Yersinia enterocolitica serotype 3 in autoimmune thyroid diseases. Endocrinol. Jpn., 1990, 37(4), 489-500.
[http://dx.doi.org/10.1507/endocrj1954.37.489] [PMID: 2083529]
[35]
Chatzipanagiotou, S.; Legakis, J.N.; Boufidou, F.; Petroyianni, V.; Nicolaou, C. Prevalence of Yersinia plasmid-encoded outer protein (Yop) class-specific antibodies in patients with Hashimoto’s thyroiditis. Clin. Microbiol. Infect., 2001, 7(3), 138-143.
[http://dx.doi.org/10.1046/j.1469-0691.2001.00221.x] [PMID: 11318812]
[36]
Wenzel, B.E. In: Chronic infection with Yersinia enterocolitica in patients with clinical or latent hyperthyroidism.The Genus Yersinia; Springer, 2004, pp. 463-466.
[http://dx.doi.org/10.1007/0-306-48416-1_92]
[37]
Brix, T.H.; Hansen, P.S.; Hegedüs, L.; Wenzel, B.E. Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves’ disease: evidence from a twin case-control study. Clin. Endocrinol. (Oxf.), 2008, 69(3), 491-496.
[http://dx.doi.org/10.1111/j.1365-2265.2008.03227.x] [PMID: 18284638]

Rights & Permissions Print Cite
Article Metrics
55
1
© 2024 Bentham Science Publishers | Privacy Policy