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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Letter Article

Efficient and Green Synthesis of Bis(indolyl)Methanes using Thiamine Hydrochloride as an Organocatalyst: A Parallel Scrutiny of Microwave Irradiation versus Ultrasonicator Heating in Water

Author(s): Nitin M. Thorat*, Kiran D. Dhawale, Sandeep B. Kasar, Manali S. Thopate, Limbraj R. Patil and Shankar R. Thopate

Volume 17, Issue 8, 2020

Page: [679 - 684] Pages: 6

DOI: 10.2174/1570179417666200620215101

Price: $65

Abstract

Thiamine hydrochloride is reported to be a highly competent promoter for the synthesis of bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst. Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of thiamine hydrochloride makes this method an alternative approach. Present protocol is a simple and eco-friendly approach for the synthesis of bis(indolyl)methanes under microwave and ultrasonicator conditions.

Keywords: Microwave condition, ultrasonicator condition, green catalyst, vitamin B1, one-pot synthesis, solvent free condition.

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