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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

The Analysis and Crystallographic Characterization of 20-Hydroxyecdysone.

Author(s): Maria Bathori, Alajos Kalman, Gyula Argay and Huba Kalasz

Volume 7, Issue 12, 2000

Page: [1305 - 1312] Pages: 8

DOI: 10.2174/0929867003374165

Price: $65


20-Hydroxyecdysone (20E) is an insect molting hormone that is also widely spread in various plants. Many chromatographic methods can be used to identify and/or determine 20E content in samples of biological origin and various spectroscopic methods serve to identify its structural elements. We have utilized X-ray crystallography to reveal the stereostructures of 20E. Our data demonstrates that 20E exists in two different crystalline forms that are both orthorhombic modifications. One form is homo-molecular, with a limited freedom of internal rotation of the side chain around the C23-C24 bond and the other, which is a clathrate formed with methanol and water, which minimize the conformational freedom of the side chain.

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