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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Recent Advances in Transition Metal Free Synthetic Protocols for Quinoline Derivatives

Author(s): Rukhsana Tabassum*, Muhammad Ashfaq* and Hiroyuki Oku

Volume 24, Issue 16, 2020

Page: [1815 - 1852] Pages: 38

DOI: 10.2174/1385272824999200616122557

Price: $65


The quinoline moiety is a privileged scaffold among heterocyclic compounds that is an important construction motif in the fields of pharmaceutical chemistry. Quinoline molecule possesses a variety of therapeutic activities like antiviral, antimalarial, antibacterial, antitumor, anticancer, antioxidant antihypertensive, antifungal, anthelmintic, cardiotonic, anticonvulsant and anti-inflammatory. This review provides an insight into recent development in transition metal free novel and modified conventional synthetic routes to yield a wide variety of substituted quinolines.

Keywords: Quinoline, quinoline derivatives, transition metal free, heterocyclic compounds, synthetic protocols, therapeutic activities.

Graphical Abstract
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