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Current Vascular Pharmacology


ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Research Article

Paget’s Disease of Bone and Cardiovascular Risk: A Pilot Study

Author(s): Agostino Gaudio*, Luca Zanoli, Anastasia Xourafa, Rosario Rapisarda, Antonino Catalano, Salvatore Santo Signorelli and Pietro Castellino

Volume 19, Issue 4, 2021

Published on: 09 June, 2020

Page: [423 - 428] Pages: 6

DOI: 10.2174/1389450121666200609151555

Price: $65


Background: The association between Paget’s disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting.

Objective: Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB.

Methods: We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of PDB was based on clinical, radiological and biochemical parameters.

Results: Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased.

Conclusion: These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or the high levels of oxidative stress that characterize this population.

Keywords: Paget's disease of bone, carotid intima-media thickness, pulse wave velocity, cardiovascular risk, disorder bone.

Graphical Abstract
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