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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article (Mini-Review)

PD-L1 Inhibitors for the Treatment of Prostate Cancer

Author(s): Matteo Santoni*, Francesco Massari, Liang Cheng, Alessia Cimadamore, Marina Scarpelli, Rodolfo Montironi and Antonio Lopez-Beltran

Volume 21 , Issue 15 , 2020

Page: [1558 - 1565] Pages: 8

DOI: 10.2174/1389450121666200609142219

Price: $65

Abstract

The carcinogenesis of prostate cancer (PCa) results from a complex series of events. Chronic inflammation and infections are crucial in this context. Infiltrating M2 type macrophages, as well as neutrophils and T lymphocytes, contribute to PCa development, progression and response to therapy. The preliminary findings on the efficacy of immunotherapy in patients with PCa were not encouraging. However, a series of studies investigating anti-PD-L1 agents such as Atezolizumab, Avelumab and Durvalumab used alone or in combination with other immunotherapies, chemotherapy or locoregional approaches are in course in this tumor. In this review, we illustrate the role of immune cells and PD-L1 expression during PCa carcinogenesis and progression, with a focus on ongoing clinical trials on anti-PD-L1 agents in this context.

Keywords: Atezolizumab, avelumab, durvalumab, immunotherapy, PD-L1, prostate cancer.

Graphical Abstract
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