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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Systematic Review Article

A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds

Author(s): Victor de Albuquerque Wanderley Sales*, Taysa Renata Ribeiro Timóteo, Natália Millena da Silva, Camila Gomes de Melo, Aline Silva Ferreira, Marcos Victor Gregório de Oliveira, Emerson de Oliveira Silva, Larissa Morgana dos Santos Mendes, Larissa Araújo Rolim and Pedro José Rolim Neto

Volume 28 , Issue 10 , 2021

Published on: 25 May, 2020

Page: [2062 - 2076] Pages: 15

DOI: 10.2174/0929867327666200525160556

Price: $65


Background: Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health.

Objective: This systematic review aimed to provide the evidence in the literature of the preclinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in the inflammatory process.

Methods: Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect, Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications and writing of this systematic review were based on the guidelines mentioned in the PRISMA statement. Moreover, the assessment of the methodological quality of the selected studies was also performed.

Results: From a total of 3018 studies, 16 studies were included in this paper based on our eligibility criteria, which showed promising and consistent results.

Conclusion: Further research concerning specific inflammatory conditions is required.

Keywords: Gallium composts, inflammation, pro-inflammatory mediators, regeneration, medicinal chemistry, inorganic compounds.

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