Generic placeholder image

New Emirates Medical Journal

ISSN (Online): 0250-6882

Case Report

BK Polyoma Virus Nephropathy in an Immunocompromised Host

Author(s): Faraz Khan*, Maroun El Khoury, Fahad Kouli and Aaron Han

Volume 2, Issue 1, 2021

Published on: 20 May, 2020

Page: [45 - 49] Pages: 5

DOI: 10.2174/0250688201999200520125625

open access plus


Background: Post-transplant Lymphoproliferative Disorders (PTLD) are a well known late complication after solid organ transplantation, including renal transplant. Among others, graft failure due to reactivation of BK polyomavirus in the grafted kidney is also a well-recognized complication but tends to present early in the first several months after transplant.

Case: Here we present the case of PTLD Burkitt's Lymphoma (BL-PTLD) in a renal transplant patient who was successfully treated with multiagent chemo-immunotherapy but later developed BK polyomavirus nephropathy (BKVN) with graft failure only after completion of her systemic therapy for lymphoma and 7 years after the transplant. Relevant literature is reviewed.

Conclusion: In this case, reactivation and progression of BKVN were most likely associated with immunosuppression from chemo-immunotherapy for her BL–PTLD, unlike early graft failures associated with BKVN.

Keywords: PTLD, Burkitt's Lymphoma, BK polyomavirus nephropathy, Lymphoproliferative disorders, Immunosuppression, Chemoimmunotherapy.

Engels EA, Pfeiffer RM, Fraumeni JF Jr, et al. Spectrum of cancer risk among US solid organ transplant recipients. JAMA 2011; 306(17): 1891-901.
[] [PMID: 22045767]
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66(1): 7-30.
[] [PMID: 26742998]
Quinlan SC, Pfeiffer RM, Morton LM, Engels EA. Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States. Am J Hematol 2011; 86(2): 206-9.
[] [PMID: 21264909]
PAya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, habermann TM, Weisner PH, Swinnen JL, Woodle ES, Bromberg JS.. Ebstein Barr virus induced post transplant lymphoproliferative disorders: AST S/AST P EBV–PTLD task force in the Mayo Clinic organized international consensus development meeting. Transplantation 1999; 68(151): 7-25.
Dierickx D, Habermann TM. Post transplant lymphoproliferative disorders in adults. NEJM 2018; 378(6): 549-62.
Bobillo S, Abrisqueta P, Sánchez-González B, et al. (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea (GEL/TAMO cooperative group).Post transplant monomorphic Burkitt’s lymphoma: Clinical characteristics and outcome of a multicentric series. Ann Hematol 2018; 97(12): 2417-24.
[] [PMID: 30116871]
Mischitelli M, Bellizzi A, Anzivino E, et al. Complications post renal transplantation: literature focus on BK virus nephropathy and diagnostic tools actually available. Virol J 2008; 5: 38.
[] [PMID: 18315864]
Ambalathingal GR, Francis RS, Smyth MJ, Smith C, Khanna R. BK polyoma virus: Clinical aspects, immune regulation and emerging therapies. Clin Microbiol Rev 2017; 30(2): 503-28.
[] [PMID: 28298471]
Babel N, Volk HD, Reinke P. BK polyomavirus infection and nephropathy: the virus-immune system interplay. Nat Rev Nephrol 2011; 7(7): 399-406.
[] [PMID: 21610680]
Sharma SG, Nickeleit V, Herlitz LC, et al. BK polyoma virus nephropathy in the native kidney. Nephrol Dial Transplant 2013; 28(3): 620-31.
[] [PMID: 23249622]
Pham PT, Reddy UG. Immunosuppression and risk of polyoma virus BK replication. 2013; 9: pp. 135-6.

© 2023 Bentham Science Publishers | Privacy Policy