Generic placeholder image

Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989


Counter-regulatory ‘Renin-Angiotensin’ System-based Candidate Drugs to Treat COVID-19 Diseases in SARS-CoV-2-infected Patients

Author(s): Cédric ANNWEILER, Zhijian CAO, Yingliang WU, Emmanuelle FAUCON, Stéphanie MOUHAT, Hervé KOVACIC and Jean-Marc SABATIER

Volume 20, Issue 4, 2020

Page: [407 - 408] Pages: 2

DOI: 10.2174/1871526520666200518073329

Perlot, T.; Penninger, J.M. ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect., 2013, 15(13), 866-873.
[] [PMID: 23962453]
Cao, Z.; Wu, Y.; Faucon, E.; Sabatier, J.M. SARS-CoV-2 & Covid-19: key-roles of the ‘renin-angiotensin’ system/vitamin D impacting drug and vaccine developments. Infect. Disord. Drug Targets, 2020, 20(3), 348-349.
[] [PMID: 32370727]
Leung, P.S. The modulatory action of vitamin D on the renin-angiotensin system and the determination of hepatic insulin resistance. Molecules, 2019, 24(13), 2479-2482.
[] [PMID: 31284538]
Ajabshir, S.; Asif, A.; Nayer, A. The effects of vitamin D on the renin-angiotensin system. J. Nephropathol., 2014, 3(2), 41-43.
[PMID: 24772394]
Aranow, C. Vitamin D and the immune system. J. Investig. Med., 2011, 59(6), 881-886.
[] [PMID: 21527855]
Ilie, P.C.; Stefanescu, S.; Smith, L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin. Exp. Res., 2020, 32(7), 1195-1198.
[] [PMID: 32377965]
Daneshkhah, A.; Eshein, A.; Subramanian, H.; Roy, H.K.; Backman, V. The role of vitamin D in suppressing cytokine storm in COVID-19 patients and associated mortality medRxiv preprint, 2020.
Wan, Y.; Shang, J.; Graham, R.; Baric, R.S.; Li, F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J. Virol., 2020, 94(7), 1-9.
[] [PMID: 31996437]
Lan, J.; Ge, J.; Yu, J.; Shan, S.; Zhou, H.; Fan, S.; Zhang, Q.; Shi, X.; Wang, Q.; Zhang, L.; Wang, X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature, 2020, 581(7807), 215-220.
[] [PMID: 32225176]
Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Herrler, T.; Erichsen, S.; Schiergens, T.S.; Herrler, G.; Wu, N.H.; Nitsche, A.; Müller, M.A.; Drosten, C.; Pöhlmann, S. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell, 2020, 181(2), 271-280.e8.
[] [PMID: 32142651]
Magrone, T.; Magrone, M.; Jirillo, E. Focus on receptors for coronaviruses with special reference to Angiotensin-converting Enzyme 2 as a potential drug target – A perspective. Endocr. Metab. Immune Disord. Drug Targets, 2020, 20(6), 807-811.
[] [PMID: 32338224]
Rudemiller, N.P.; Crowley, S.D. Interactions between the immune and the renin-angiotensin systems in hypertension. Hypertension, 2016, 68(2), 289-296.
[] [PMID: 27354427]
Crowley, S.D.; Rudemiller, N.P. Immunologic effects of the renin-angiotensin system. J. Am. Soc. Nephrol., 2017, 28(5), 1350-1361.
[] [PMID: 28151411]
Vaduganathan, M.; Vardeny, O.; Michel, T.; McMurray, J.J.V.; Pfeffer, M.A.; Solomon, S.D. Renin-Angiotensin-Aldosterone system inhibitors in patients with Covid-19. N. Engl. J. Med., 2020, 382(17), 1653-1659.
[] [PMID: 32227760]
Paz Ocaranza, M.; Riquelme, J.A.; García, L.; Jalil, J.E.; Chiong, M.; Santos, R.A.S.; Lavandero, S. Counter-regulatory renin-angiotensin system in cardiovascular disease. Nat. Rev. Cardiol., 2020, 17(2), 116-129.
[] [PMID: 31427727]

© 2023 Bentham Science Publishers | Privacy Policy