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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

New Strategies for Safe Cancer Therapy Using Electrospun Nanofibers: A Short Review

Author(s): Mohsen Doostmohammadi, Hamid Forootanfar* and Seeram Ramakrishna*

Volume 20, Issue 13, 2020

Page: [1272 - 1286] Pages: 15

DOI: 10.2174/1389557520666200513120924

Price: $65


Electrospun nanofibers regarding their special features, including high drug loading capacity, high surface to volume area, flexibility, and ease of production and operation, are of great interest for being used in tissue engineering, and drug delivery approaches. In this context, several studies have been done for the production of biodegradable and biocompatible scaffolds containing different anticancer agents for fighting with solid tumors. Surprisingly, these scaffolds are able to deliver different combinations of drugs and agents, such as nanoparticles and release them in a time dependent manner. Here in this review, we summarize the principles of electrospinning and their uses in entrapment of drugs and anti-proliferative agents suitable for cancer therapy. The latest studies performed on treating cancer using electrospinning are mentioned and their advantages and disadvantages over conventional treatment methods are discussed.

Keywords: Electrospun nanofibers, anticancer, tissue engineering, nanoparticle, tumor, drugs.

Graphical Abstract
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