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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Mini-Review Article

Application, Reactivity and Synthesis of Isoxazole Derivatives

Author(s): Yogesh Walunj, Pravin Mhaske and Pramod Kulkarni*

Volume 18, Issue 1, 2021

Published on: 11 May, 2020

Page: [55 - 77] Pages: 23

DOI: 10.2174/1570193X17999200511131621

Price: $65


In this review article, we describe the application, reactivity and synthesis of isoxazole derivatives, more specifically, the application, reactivity, and synthesis of 3,5-disubstituted, 3,4- disubstituted, and 3,4,5-trisubstituted isoxazole using the green method. We review the application of isoxazole in material science, agriculture and pharmaceutical. In material science, isoxazole is used as a photochromic, electrochemical probe for Cu2+ and, given its optical properties, in dye-sensitized solar cells, high energy material and liquid crystal. In agriculture, isoxazole is used as an insecticide for managing Callosobruchus chinensis, Acaricidal activity against T. cinnabarinus, and herbicidal activities of 2-cyanoacrylates containing isoxazole. In pharmaceutical, isoxazole shows anticancer, antituberculosis, anti-inflammatory, and acetylcholinesterase inhibitors. Further, we describe various reactions of isoxazole such as ring opens, bromination and iodination, thioynol ethers, intramolecular SEAr reaction, arylation, cycloaddition and photocycloaddition, photoisomerization, Domino transformation of isoxazoles to 2,4-dicarbonyl pyrroles and rearrangement. We also describe the synthesis of 3,5-disubstituted, 3,4-disubstituted and 3,4,5-trisubstituted isoxazole using different methods.

Keywords: Agriculture, disubstituted, isoxazole, material science, pharmaceutical, reaction, synthesis, trisubstituted.

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