Generic placeholder image

Cardiovascular & Hematological Disorders-Drug Targets


ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

Research Article

Vascular Effects of Avocado Seed Glycosides during Diabetes-induced Endothelial Damage

Author(s): Peter U. Amadi*, Emmanuel N. Agomuo and Chiamaka Adumekwe

Volume 20, Issue 3, 2020

Page: [202 - 213] Pages: 12

DOI: 10.2174/1871529X20666200510012012


Background and Objectives: The relationship between vascular damage and diabetes mellitus was exploited using avocado seed extracts. The purpose of the study was to understand the therapeutic relevance of glycosides compared to standard vascular and anti-diabetic drugs. Constituent Avocado Seed Glycosides (ASG) were analysed and administered to rats with Diabetes-Induced Vascular Damage (DIVD).

Methods: The rats were first administered with streptozotocin and screened after seven days for alterations in blood glucose, insulin, vascular cell adhesion molecule (VCAM-1), Von Willebrand factor (VWF), Renin-Angiotensin-Aldosterone System (RAS), eNOx, and endothelin-1 (ET-1). Only rats that satisfied these criteria were recruited and treated with either glibenclamide, + losart, or 200 mg/kg body weight ASG for 28 days.

Results: There was an abundance of digitoxin (13.41 mg/100g), digoxin (17.98 mg/100g), avicularin (165.85 mg/100g), and hyperoside (282.51 mg/100g). ASG or + losart exhibited slight modulatory properties on glucose homeostasis. Rats with DIVD showed elevated renin, angiotensin, VCAM-1 and Lp-PLA2 levels but slightly decreased with glibenclamide treatment and normalized with ASG or + losart administration. All treatments normalized Hcy levels. DIVD caused the overproduction of CnT, LDH, Crt-K, LDL-c, TG, and TC and suppressed HDL-c but was completely normalized by the ASG. Water intake remained altered in treated rats.

Conclusion: The ASG had no relevant effect on glucose homeostasis during DIVD but showed significant vasoprotective properties.

Keywords: Vascular damage, endothelium, avocado seed, glycosides, cardiac integrity, diabetes.

Graphical Abstract

© 2023 Bentham Science Publishers | Privacy Policy