Abstract
The genus Dorstenia contains many plants that are used as antisnakebite, anti-infection and anti-rheumatic remedies in the medicinal plant therapy of many countries in Africa, Central and South America. The genus is now recognized as a rich source of prenyl and geranyl-substituted coumarins, chalcones, flavones and flavanones. The first examples of naturally occurring styrenes (2 and 3) were reported from D. barnimiana. The geranyl substituted furocoumarin (5) has been found in many species. D. poinsettifolia furnished the unusual 4-phenyl substituted dihydrocoumarin, and the rare geranyl and prenyl substituted chalcone (17). Prenylated flavonoids have so far been reported from African Dorstenia only. Compound 18 from D. proropens is the only example of a bis-geranylated chalcone in the literature. D. manni furnished the novel chalcone (13), 6-prenylchrysoeriol (22 R = OMe), the geranyl derivative (43), eight diprenylated flavanones (28, 30-36) and one flavonol (29). These dorsmannins appear to be derived from 6,8-diprenyleriodictyol and a possible biosynthetic scheme for them is presented (Fig. 5). Compound 21 was reported from D. zenkeri and is believed to arise from 20. The latter is probably formed via an enzymatic Diels-Alder reaction of isobavachalcone (10) and its dehydroderivative (19). D. psilurus provided all the triprenylated compounds (37-42) found in Dorstenia and, of these, 42 is unique in having ring B of the flavonoid structure modified to a dienone. The pharmacological data on this genus are scanty. Extracts of D. multiradiata show antileishmanial activity. Extracts and/or compounds from other species show anti-inflammatory, analgesic, anti-oxidant and cytotoxic activities
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
Related Books
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
10