Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Cytotoxicity and Anti-cancer Activity of the Genus Achillea L.

Author(s): Konstantina Papakosta, Maria-Eleni Grafakou, Christina Barda, Ioannis V. Kostopoulos, Ourania Tsitsilonis and Helen Skaltsa*

Volume 27, Issue 41, 2020

Page: [6910 - 6925] Pages: 16

DOI: 10.2174/0929867327666200505092514

Price: $65


Background: The genus Achillea L. is rich in bioactive sesquiterpenes and flavonoids; most of the studied species exhibit several biological activities and are used as emmenagogue, wound healing and analgesic agents. Some species are also used in local folklore medicine.

Objective: Following a literature survey, we discuss the anti-cancer properties of Achillea species, taking into consideration ethnopharmacological data on their use in traditional medicine for the treatment of cancer. In addition, we screened extracts and isolated secondary metabolites from A. coarctata for cytotoxicity, upon information based on local traditional medicine. The plant was collected in Kozani (Northern Greece), where it is locally used for treating gastrointestinal disorders, including stomach cancer.

Methods: A selection of the relevant data was performed through a search in PubMed, Scopus, Google Scholar and Science Direct databases. In addition, extracts and isolated compounds from A. coarctata were tested for their in vitro activity against the human cancer cell lines MCF-7 and HeLa.

Conclusion: The genus Achillea L. is a valuable source of bioactive secondary metabolites. The most significant outcome of the investigation of medicinal plants is the documentation and the assessment of the traditional information and its use and perspectives in the light of modern pharmacology.

Keywords: Achillea L., A. coarctata Poir., cancer, cytotoxicity, HeLa cells, MCF-7 cells, sesquiterpene lactones.

Latest global cancer data- World Health Organizations: Available at: (Accessed at: March, 2020)
Golubnitschaja, O.; Debald, M.; Yeghiazaryan, K.; Kuhn, W.; Pešta, M.; Costigliola, V.; Grech, G. Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumour Biol., 2016, 37(10), 12941-12957.
[] [PMID: 27448308]
Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R.L.; Torre, L.A.; Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 2018, 68(6), 394-424.
[] [PMID: 30207593]
Harborne, J.B.; Baxter, H. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants; Taylor & Francis Limited, 1993.
Campos-Vega, R.; Oomah, B.D. Chemistry and classification of phytochemicals in: Handbook of Plant Food Phytochemicals; B., Tiwari; N.P., Brunton; C.S., Brennan, Eds.; John Wiley & Sons Ltd., 2013.
[ ]
Newman, D.J.; Cragg, G.M.; Kingston, D.G.I. Natural products as pharmaceuticals and sources for lead structures in: The Practice of Medicinal Chemistry; Wermuth, C.G., Ed.; Academic Press, 2008, pp. 159-186.
Iqbal, J.; Abbasi, A.; Mahmood, T.; Kanwal, S.; Ali, B.; Shah, A.A.; Khalil, A.T. Plant-derived anticancer agents: a green anticancer approach. Asian Pac. J. Trop. Biomed., 2017, 7, 1129-1150.
Sisodiya, P.S. Plant derived anticancer agents: a review. Int. J. Res. Dev. Pharm. L. Sci., 2013, 2(2), 293-308.
Amin, A.; Gali-Muhtasib, H.; Ocker, M.; Schneider-Stock, R. Overview of major classes of plant-derived anticancer drugs. Int. J. Biomed. Sci., 2009, 5(1), 1-11.
[PMID: 23675107]
Pezzuto, J.M. Plant-derived anticancer agents. Biochem. Pharmacol., 1997, 53(2), 121-133.
[] [PMID: 9037244]
Estrela, J.M.; Mena, S.; Obrador, E.; Benlloch, M.; Castellano, G.; Salvador, R.; Dellinger, R.W. Polyphenolic phytochemicals in cancer prevention and therapy: bioavailability versus bioefficacy. J. Med. Chem., 2017, 60(23), 9413-9436.
[] [PMID: 28654265]
Wang, H.; Khor, T.O.; Shu, L.; Su, Z.Y.; Fuentes, F.; Lee, J.H.; Kong, A.N. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer. Agents Med. Chem., 2012, 12(10), 1281-1305.
[] [PMID: 22583408]
Kapinova, A.; Kubatka, P.; Golubnitschaja, O.; Kello, M.; Zubor, P.; Solar, P.; Pec, M. Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention. Environ. Health Prev. Med., 2018, 23(1), 36.
[] [PMID: 30092754]
Mollakhalili Meybodi, N.; Bahadori Monfared, A.; Sohrabvandi, S.; Aghaei Meybodi, F. Phytochemicals in cancer prevention: a review of the evidence. Iran. J. Cancer Prev., 2017.
Oh, J.; Hlatky, L.; Jeong, Y.S.; Kim, D. Therapeutic effectiveness of anticancer phytochemicals on cancer stem cells. Toxins (Basel), 2016, 8(7), 1-11.
[] [PMID: 27376325]
Johnson, I.T. Phytochemicals and cancer. Proc. Nutr. Soc., 2007, 66(2), 207-215.
[] [PMID: 17466103]
Simon, J.J. Phytochemicals & cancer. J. Chiropr. Med., 2002, 1(3), 91-96.
[] [PMID: 19674567]
Saeidnia, S.; Gohari, A.; Mokhber-Dezfuli, N.; Kiuchi, F. A review on phytochemistry and medicinal properties of the genus Achillea. Daru, 2011, 19(3), 173-186.
[PMID: 22615655]
Totelin, L.M.V. Hippocratic Recipes: Oral and Written Transmission of Pharmacological Knowledge in Fifth- and Fourth-Century Greece; Brill: Leiden, The Netherland, 2009.
Dioscorides, P. Dioscurides, De Materia Medica Libri Quinque: Libri III Et IV. Pedanii Dioscuridis Anazarbei De Materia Medica libri quinque, IV, 3rd ed; Wellmann, M., Ed.; Weidmann: Berlin, 1958, p. 36.
Nemeth, E.; Bernath, J. Biological activities of yarrow species (Achillea sp.). Curr. Pharm. Des., 2008, 14(29), 3151-3167.
[] [PMID: 19075697]
Vokou, D.; Katradi, K.; Kokkini, S. Ethnobotanical survey of Zagori (Epirus, Greece), a renowned centre of folk medicine in the past. J. Ethnopharmacol., 1993, 39(3), 187-196.
[] [PMID: 8258976]
Shikov, A.N.; Tsitsilin, A.N.; Pozharitskaya, O.N.; Makarov, V.G.; Heinrich, M. Traditional and current food use of wild plants listed in the Russian pharmacopoeia. Front. Pharmacol., 2017, 8, 841.
[] [PMID: 29209213]
Mohammadhosseini, M.; Sarker, S.D.; Akbarzadeh, A. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: a review. J. Ethnopharmacol., 2017, 199, 257-315.
[ ] [PMID: 28179115]
Tutin, T.G.; Heywood, V.H.; Burges, N.; Moore, D.M.; Valentine, D.H.; Walters, S.M.; Webb, D.A. 58. Achillea L. In: Flora Europaea Plantaginaceae to Compositae (and Rubiaceae); Cambridge University Press: Cambridge, 1976; 4, pp. ()159-165.
Strid, A.; Tan, K. Mountain flora of Greece; 2 Ed; Edinburgh University Press: Endinburgh, 1991.
EMA/HMPC/290284/2009 Available at: (Accessed at: 12 March, 2020)
Si, X.T.; Zhang, M.L.; Shi, Q.W.; Kiyota, H. Chemical constituents of the plants in the genus Achillea. Chem. Biodivers., 2006, 3(11), 1163-1180.
[] [PMID: 17193231]
Sak, K.; Jürisoo, K.; Raal, A. Estonian folk traditional experiences on natural anticancer remedies: from past to the future. Pharm. Biol., 2014, 52(7), 855-866.
[] [PMID: 24920231]
Coll, J.C.; Bowden, B.F. The application of vacuum liquid chromatography to the separation of terpene mixtures. J. Nat. Prod., 1986, 49, 934-936.
Hostettmann, K.; Marston, A.; Hostettmann, M. Preparative Chromatography Techniques; Springer-Verlag Berlin Heidelberg: Germany: New York, NY, USA, 1998.
Irwin, M.A.; Geissman, T.A. Rupicolin-A and -B, rupin-A and -B, and cumambrin-B oxide from Artemisia tripartita ssp. Rupicola. Phytochemistry, 1973, 12, 863-869.
Bohlmann, F.; Knoll, K.H.; Robinson, H.; King, R.M. Neue guaianolide aus Cocosmia rugosa. Phytochemistry, 1980, 19, 599-602.
Zitterl-Eglseer, K.; Jurenitsch, J.; Korhammer, S.; Haslinger, E.; Sosa, S.; Della Loggia, R.; Kubelka, W.; Franz, C. Entzün-dungshemmende Sesquiterpenlactone von Achillea setacea. Sesquiterpenelactones of Achillea setacea with Antiphlogistic activity. Planta Med., 1991, 57(5), 444-446.
[] [PMID: 1798798]
Kwon, H.C.; Choi, S.Z.; Lee, W.B.; Min, Y.D.; Yang, M.C.; Chung, A.K.; Lee, K.H.; Lee, K.R. Sesquiterpene lactones of Artemisia sylvatica. Yukhuk Hooji, 2001, 45, 147-152.
Ohno, N.; Gershenzon, J.; Roane, C.; Mabry, I.J. 11, 13-dehydrodesacetyl- matricarin and other sesquiterpene lactones from Artemisia ludoviciana var. ludoviciana and the identity of artecanin and chrysartemin B. Phytochemistry, 1980, 19, 103-106.
Daniewski, W.; Skibicki, P.; Gumulka, M.; Drozdz, B.; Grabarczyk, H.; Bloszyk, E. Sesquiterpene lactones. XXXV. Constituents of Reichardia tingitana L. Roth. and their antifeedant activity. Acta Soc. Bot. Pol., 1988, 57, 539-545.
Werner, I.; Glasl, S.; Presser, A.; Haslinger, E.; Jurenitsch, J. Sesquiterpenes from Achillea pannonica Scheele. Z. Natforsch. C J. Biosci., 2003, 58(5-6), 303-307.
[] [PMID: 12872918]
Geissman, T.A.; Griffin, T.S.; Irwin, M.A. Sesquiterpene lactones of Artemisia. Artecalin from A. californica and A. tripertita ssp. rupicola. Phytochemistry, 1969, 8, 1297-1300.
Ahmed, A.A. Gati, T.; Hussein, T.A.; Ali, A.T., Tzakou, O.A.; Couladis, M.A.; Mabry, T.J.; Toth, G. Ligustolide A and B, two novel sesquiterpenes with rare skeletons and three 1,10-seco-guaianolide derivatives from Achillea ligustica. Tetrahedron, 2003, 59, 3729-3735.
Park, H-J.; Cho, J-G.; Baek, Y-S.; Seo, K-H.; Kim, S-Y.; Choi, M-S.; Lee, K-T.; Jeong, T-S.; Chung, H-G.; Kang, E-G.; Baek, N-I. Identification of bitter components from Artemisia princeps Pamp. Food Sci. Biotechnol., 2016, 25(1), 27-32.
[] [PMID: 30263232]
Todorova, M.N.; Krasteva, M.L. Sesquiterpene lactones from Artemisia lerchiana. Phytochemistry, 1996, 42, 1231-1233.
Ni, Z.; Wu, Y.; Zhang, K.; Dong, M.; Sauriol, F.; Huo, C.; Gu, Y.; Shi, Q. A monoterpene and two sesquiterpenoids from the flowers of Achillea millefolium. Chem. Nat. Compd., 2013, 49, 450-453.
Grabarczyk, M.; Wińska, K.; Mączka, W.; Potaniec, B.; Aniol, M. Loliolide-the most ubiquitous lactone. Biol. Oecol., 2015, 11, 1-8.
Peng, Y.; Huang, R-M.; Lin, X-P.; Liu, Y-H. Norisoprenoids from the brown alga sargassum naozhouense tseng et lu. Molecules, 2018, 23(2), 348.
[] [PMID: 29414891]
Barberá, O.; Marco, J.A.; Sanz, J.F.; Sánchez-Parareda, J. 3 Methoxyflavones and coumarins from Artemisia incanescens. Phytochemistry, 1986, 25, 2357-2360.
Glasl, S.; Mucaji, P.; Werner, I.; Presser, A.; Jurenitsch, J. Sesquiterpenes and flavonoid aglycones from a Hungarian taxon of the Achillea millefolium group. Z Naturforsch, 2002, 57(11-12), 976-982.
[] [PMID: 12562079]
Huo, C-H.; Li, Y.; Zhang, M-L.; Wang, Y-F.; Zhang, Q.; Qin, F.; Shi, Q-W.; Kiyota, H. Cytotoxic flavonoids from the flowers of Achillea millefolium L. Chem. Nat. Compd., 2013, 48, 958-962.
[ ]
Valant-Vetschera, K.M.; Wollenweber, E. Comparative analysis of leaf exudate flavonoids in Achillea sect. Filipendulinae. Biochem. Syst. Ecol., 1996, 24, 435-446.
Basnet, P.; Matsushige, K.; Hase, K.; Kadota, S.; Namba, T. Four di-O-caffeoyl quinic acid derivatives from propolis. Potent hepato-protective activity in experimental liver injury models. Biol. Pharm. Bull., 1996, 19(11), 1479-1484.
[] [PMID: 8951168]
Kodoma, M.; Wada, H.; Otani, H.; Kohmoto, K.; Kimura, Y. 3, 5-Di-O-caffeoylquinicacid, aninfection-inhibiting factor from Pyrus pyrifolia induced by infection with Alternaria alternata. Phytochemistry, 1997, 47, 371-373.
Lee, S.O.; Choi, S.Z.; Ryu, S.Y.; Lee, K.R. Phytochemical constituents of the aerial parts from Aster hispidus. Nat. Prod. Sci., 2004, 10(6), 335-340.
Shang, Y.F.; Kim, S.M.; Song, D-G.; Pan, C-H.; Lee, W.J.; Um, B-H. Isolation and identification of antioxidant compounds from Ligularia fischeri. J. Food Sci., 2010, 75(6), C530-C535.
[] [PMID: 20722907]
Wan, C.; Li, S.; Liu, L.; Chen, C.; Fan, S. Caffeoylquinic acids from the aerial parts of Chrysanthemum coronarium L. Plants (Basel), 2017, 6(1), 10.
[] [PMID: 28218654]
Zhu, X-F.; Zhang, H-X.; Lo, R. Three di-O-caffeoylquinic acid derivatives from the heads of Cynara scolymus L. Nat. Prod. Res., 2009, 23(6), 527-532.
[] [PMID: 19384729]
Li, L.; Henry, G.E.; Seeram, N.P. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. J. Agric. Food Chem., 2009, 57(16), 7282-7287.
[] [PMID: 19627089]
Jakupovic, J.; Tan, R.X.; Bohlmann, F.; Boldt, P.E.; Jia, Z.J. Sesquiterpene lactones from Artemisia ludoviciana. Phytochemistry, 1991, 30, 1573-1577.
Mabry, T.G.; Markham, K.R.; Thomas, M.B. The systematic identification of flavonoids; Springer Science & Business Media: Berlin/Heidelberg, Germany: New York, NY, USA, 1970.
Flegkas, A.; Milosević Ifantis, T.; Barda, C.; Samara, P.; Tsitsilonis, O.; Skaltsa, H. Antiproliferative activity of (-)-rabdosiin isolated from ocimum sanctum L. Medicines (Basel), 2019, 6(1), 37.
[] [PMID: 30870993]
Padilla-Gonzalez, G.F.; dos Santos, F.A.; Da Costa, F.B. Sesquiterpene lactones: more than protective plant compounds with high toxicity. Crit. Rev. Plant Sci., 2016, 0, 1-20.
Radulović, N.; Zlatković, B.; Palic, R.; Stojanović, G. Chemotaxonomic significance of the balkan achillea volatiles. Nat. Prod. Commun., 2007, 2, 453-474.
Chadwick, M.; Trewin, H.; Gawthrop, F.; Wagstaff, C. Sesquiterpenoids lactones: benefits to plants and people. Int. J. Mol. Sci., 2013, 14(6), 12780-12805.
[] [PMID: 23783276]
Agar, O.T.; Dikmen, M.; Ozturk, N.; Yilmaz, M.A.; Temel, H.; Turkmenoglu, F.P. Comparative studies on phenolic composition, antioxidant, wound healing and cytotoxic activities of selected Achillea L. species growing in Turkey. Molecules, 2015, 20(10), 17976-18000.
[] [PMID: 26437391]
Karaalp, C.; Yurtman, N.A.; Yavasoglu, N.U.K. Evaluation of antimicrobial properties of Achillea L. flower head extracts. Pharm. Biol., 2009, 47, 86-91.
Yilmaz, M.A.; Ertas, A.; Yener, I.; Akdeniz, M.; Cakir, O.; Altun, M.; Demirtas, I.; Boga, M.; Temel, H. A comprehensive LC-MS/MS method validation for the quantitative investigation of 37 fingerprint phytochemicals in Achillea species: A detailed examination of A. coarctata and A. monocephala. J. Pharm. Biomed. Anal., 2018, 154, 413-424.
[] [PMID: 29602084]
Konyalioglu, S.; Karamenderes, C. The protective effects of Achillea L. species native in Turkey against H(2)O(2)-induced oxidative damage in human erythrocytes and leucocytes. J. Ethnopharmacol., 2005, 102(2), 221-227.
[] [PMID: 16118043]
Albayrak, S.; Silahtarlioğlu, N. Cytotoxic Activity of Achillea coarctata Poir. Extract. Proceedings, 2017, 1, 1039.
Hegazy, F.M-E.; Abdel-Lateff, A.; Gamal-Eldeen, A.M. Turky, F.; Hirata, T.; Parée, P.W.; Karchesy, J.; Kamel M. S.; Ahmed, A. A. Anti-inflammatory activity of new guaiane acid derivatives from achillea coarctata. Nat. Prod. Commun., 2008, 3, 851-856.
Tzakou, O.; Couladis, M.; Milenkovic, M.; Vucicevic, D.; Kovacevic, N. Composition and antimicrobial activity of Achillea coarctata essential oils from Greece. JEOP, 2009, 12, 541-545.
[ ]
Todorova, M.; Tsankova, E. Sesquiterpene lactones from Achillea chrysocoma and Achillea coarctata. Z. Natforsch. C J. Biosci., 2001, 56(11-12), 957-960.
[] [PMID: 11837682]
Yang, L.; Wen, K-S.; Ruan, X.; Zhao, Y.X.; Wei, F.; Wang, Q. Response of plant secondary metabolites to environmental factors. Molecules, 2018, 23(4), 762.
[] [PMID: 29584636]
Bali, E.B.; Açık, L.; Elçi, P.; Sarper, M.; Avcu, F.; Vural, M. In vitro anti-oxidant, cytotoxic and pro-apoptotic effects of Achillea teretifolia willd extracts on human prostate cancer cell lines. Pharmacogn. Mag., 2015, 11(Suppl. 2), S308-S315.
[] [PMID: 26664020]
Varasteh-Kojourian, M.; Abrishamchi, P.; Matin, M.M.; Asili, J.; Ejtehadi, H.; Khosravitabar, F. Antioxidant, cytotoxic and DNA protective properties of Achillea eriophora DC. and Achillea biebersteinii Afan. Extracts: a comparative study. Avicenna J. Phytomed., 2017, 7(2), 157-168.
[PMID: 28348971]
Ghavami, G.; Sardari, S.; Shokrgozar, M.A. Anticancerous potentials of Achillea species against selected cell lines. J. Med. Plants Res., 2010, 4, 2411-2417.
Kundaković, T.; Stanojković, T.; Juranić, Z.; Kovacević, N. Cytotoxic and antioxidant activity of Achillea alexandriregis. Pharmazie, 2005, 60(4), 319-320.
[PMID: 15881617]
Gómez, M.A.; García, M.D.; Sáenz, M.T. Cytostatic activity of Achillea ageratum L. Phytother. Res., 2001, 15(7), 633-634.
[] [PMID: 11746850]
Tozyo, T.; Yoshimura, Y.; Sakurai, K.; Uchida, N.; Takeda, Y.; Nakai, H.; Ishii, H. Novel antitumor sesquiterpenoids in Achillea millefolium. Chem. Pharm. Bull. (Tokyo), 1994, 42(5), 1096-1100.
[] [PMID: 8069962]
Mosaddegh, M.; Esmaeili, S.; Naghibi, F.; Moghadam, M.H.; Haeri, A.; Pirani, A.; Moazzeni, H. Ethnomedical survey and cytotoxic activity of medicinal plant extracts used in kohgiluyeh and boyerahmad province in Iraq. J. Herbs Spices Med. Plants, 2012, 18, 211-221.
Trifunović, S.; Isaković, A.M.; Isaković, A.; Vučković, I.; Mandić, B.; Novaković, M.; Vajs, V.; Milosavljević, S.; Trajković, V. Iso-lation, characterization, and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. Planta Med., 2014, 80(4), 297-305.
[] [PMID: 24510367]
Saikali, M.; Ghantous, A.; Halawi, R.; Talhouk, S.N.; Saliba, N.A.; Darwiche, N. Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells. BMC Complement. Altern. Med., 2012, 12, 89.
[] [PMID: 22776414]
Maggi, F.; Bramucci, M.; Cecchini, C.; Coman, M.M.; Cresci, A.; Cristalli, G.; Lupidi, G.; Papa, F.; Quassinti, L.; Sagratini, G.; Vittori, S. Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: ideal candidate for anti-cariogenic formulations. Fitoterapia, 2009, 80(6), 313-319.
[] [PMID: 19379797]
Yumrutas, O.; Oztuzcu, S.; Pehlivan, M.; Ozturk, N.; Poyraz, I.E.; Iğci, Y.Z.; Cevik, M.O.; Bozgeyik, I.; Aksoy, A.F.; Bagis, H.; Arslan, A. Cell viability, anti-proliferation and antioxidant activities of Sideritis syriaca, Tanacetum argenteum subsp. Argenteum and Achillea aleppica subsp. Zederbaueri on human breast cancer cell line (MCF-7). J. App. Pharm. Sci., 2015, 5, 001-005.
Baharara, J.; Namvar, F.; Ramezani, T.; Mousavi, M.; Mohamad, R. Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. Molecules, 2015, 20, 2693-2706.
[] [PMID: 25665064]
Abu-Dahab, R.; Afifi, F. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF-7). Sci. Pharm., 2007, 75, 121-136.
Hichri, F.; Znati, M.; Janneta, H.B.; Bouajila, J. A new sesquiterpene lactone and secoguaianolides from Achillea cretica L. growing in Tunisia. Ind. Crops Prod., 2015, 77, 735-740.
[] [PMID: 29160111]
Hichri, F.; Znati, M.; Bouajila, J.; Ben Jannet, H. New cytotoxic sesquiterpene lactones from Achillea cretica L. growing in Tunisia. J. Asian Nat. Prod. Res., 2018, 20(4), 344-351.
[] [PMID: 29160111]
Bruno, M.; Rosselli, S.; Maggio, A.; Raccuglia, R.A.; Bastow, K.F.; Wu, C-C.; Lee, K-H. Cytotoxic activity of some natural and synthetic sesquiterpene lactones. Planta Med., 2005, 71(12), 1176-1178.
[] [PMID: 16395659]
Awad, B.M.; Habib, E.S.; Ibrahim, A.K.; Wanas, A.S.; Radwan, M.M.; Helal, M.A.; ElSohly, M.A.; Ahmed, S.A. Cytotoxic activity evaluation and molecular docking study of phenolic derivatives from Achillea fragrantissima (Forssk.) growing in Egypt. Med. Chem. Res., 2017, 26, 2065-2073.
Dias, M.I.; Barros, L.; Dueñas, M.; Pereira, E.; Carvalho, A.M.; Alves, R.C.; Oliveira, M.B.P.P.; Santos-Buelga, C.; Ferreira, I.C.F.R. Chemical composition of wild and commercial Achillea millefolium L. and bioactivity of the methanolic extract, infusion and decoction. Food Chem., 2013, 141(4), 4152-4160.
[] [PMID: 23993599]
Csupor-Löffler, B.; Hajdú, Z.; Zupkó, I.; Réthy, B.; Falkay, G.; Forgo, P.; Hohmann, J. Antiproliferative effect of flavonoids and ses-quiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother. Res., 2009, 23(5), 672-676.
[] [PMID: 19107850]
Haïdara, K.; Zamir, L.; Shi, Q.W.; Batist, G. The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action. Cancer Lett., 2006, 242(2), 180-190.
[] [PMID: 16387422]
Li, Y.; Ni, Z-Y.; Zhu, M-Ch.; Zhang, K.; Wu, Y-B.; Dong, M.; Shi, Q-W.; Huo, Ch-H.; Sauriol, F.; Kiyota, H.; Gu, Y-Ch.; Cong, B. Millifolides A-C. New 1,10-Seco-guaianolides from the flowers of Achillea millefolium. Z. Naturforsch., 2012, 67b, 438-446.
Saravani, R.; Galavi, H.R.; Shahraki, A. Inhibition of phosphodiesterase 5 and increasing the level of cyclic guanosine 3′,5′ mono-phosphate by hydroalcoholic Achillea wilhelmsii C. Koch extract in human breast cancer cell lines MCF-7 and MDA-Mb-468. Breast Cancer (Auckl.), 2017, 111178223417690178
[] [PMID: 28469435]
Galavi, H.R.; Saravani, R.; Shahraki, A.; Ashtiani, M. Anti-proliferative and apoptosis inducing potential of hydroalcoholic Achillea wilhelmsii C. Koch extract on human breast adenocarcinoma cell lines MCF-7 and MDA-Mb-468. Pak. J. Pharm. Sci., 2016, 29(Suppl. 6), 2397-2403.
[PMID: 28167484]
Can, G.; Demir, M.; Aydiner, A. Complementary and alternative therapies used by Turkish breast cancer patients undergoing chemo-therapy. Breast Care (Basel), 2012, 7(6), 471-475.
[] [PMID: 24715829]
Rausch, S.M.; Winegardner, F.; Kruk, K.M.; Phatak, V.; Wahner-Roedler, D.L.; Bauer, B.; Vincent, A. Complementary and alternative medicine: use and disclosure in radiation oncology community practice. Support. Care Cancer, 2011, 19(4), 521-529.
[] [PMID: 20336329]
Ahmadi-Jouibari, T.; Nikbakht, M.R.; Mansouri, K.; Majnooni, M.B. Cytotoxic effects of the essential oil from Achillea wilhelmsii C. Koch. JRPS, 2013, 2(2), 98-102.
Tian, Q.; Zang, Y.H. Antiproliferative and apoptotic effects of the ethanolic herbal extract of Achillea falcata in human cervical cancer cells are mediated via cell cycle arrest and mitochondrial membrane potential loss. J. BUON, 2015, 20(6), 1487-1496.
[PMID: 26854445]
Tohme, R.; Al Aaraj, L.; Ghaddar, T.; Gali-Muhtasib, H.; Saliba, N.A.; Darwiche, N. Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells. Molecules, 2013, 18(7), 8275-8288.
[] [PMID: 23860275]
Asadi-Samani, M.; Rafieian-Kopaei, M.; Lorigooini, Z.; Shirzad, H. A screening of growth inhibitory activity of Iranian medicinal plants on prostate cancer cell lines. Biomedicine (Taipei), 2018, 8(2), 8.
[] [PMID: 29806586]
Ashtiani, M.; Nabatchian, F.; Galavi, H.R.; Saravani, R.; Farajian-Mashhadi, F.; Salimi, S. Effect of Achillea wilhelmsii extract on expression of the human telomerase reverse transcriptase mRNA in the PC3 prostate cancer cell line. Biomed. Rep., 2017, 7(3), 251-256.
[] [PMID: 28811896]
Trifunović, S.; Vajs, V.; Juranić, Z.; Zizak, Z.; Tesević, V.; Macura, S.; Milosavljević, S. Cytotoxic constituents of Achillea clavennae from Montenegro. Phytochemistry, 2006, 67(9), 887-893.
[] [PMID: 16616262]
Kuete, V.; Wiench, B.; Alsaid, M.S.; Alyahya, M.A.; Fankam, A.G.; Shahat, A.A.; Efferth, T. Cytotoxicity, mode of action and anti-bacterial activities of selected Saudi Arabian medicinal plants. BMC Complement. Altern. Med., 2013, 13, 354.
[] [PMID: 24330397]
Alenad, S.M.; Al-Jaber, N.A.; Krishnaswamy, S.; Yakout, S.M.; Al-Daghri, N.M.; Alokail, M.S. Achillea fragrantissima extract exerts its anticancer effect via induction of differentiation, cell cycle arrestand apoptosis in chronic myeloid leukemia (CML) cell line K562. J. Med. Plants Res., 2013, 7, 1561-1567.
Ghantous, A.; Nasser, N.; Saab, I.; Darwiche, N.; Saliba, N.A. Structure-activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth. Eur. J. Med. Chem., 2009, 44(9), 3794-3797.
[] [PMID: 19464086]
Sathiyamoorthy, P.; Lugasi-Evgi, H.; Schlesinger, P.; Kedar, I.; Gopas, J.; Pollack, Y.; Golan-Goldhirsh, A. Screening for cytotoxic and antimalarial activities in desert plants of the negev and bedouin market plant products. Pharm. Biol., 1999, 37, 188-195.
Pereira, J.M.; Peixoto, V.; Teixeira, A.; Sousa, D.; Barros, L.; Ferreira, I.C.F.R.; Vasconcelos, M.H. Achillea millefolium L. hydroeth-anolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis. Food Chem. Toxicol., 2018, 118, 635-644.
[] [PMID: 29883784]
Yong, L.; Man-Li, Z.; Cong, B.; Wang, S-M.; Dong, M.; Sauriol, F.; Huo, C-H.; Shi, Q-W.; Gu, Y-C.; Kiyota, H. Achillinin A, a cytotoxic guaianolide from the flower of yarrow, Achillea millefolium. Biosci. Biotechnol. Biochem., 2011, 75(8), 1554-1556.
[ ] [PMID: 21821943]
Lin, L-T.; Liu, L-T.; Chiang, L-C.; Lin, C.C. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother. Res., 2002, 16(5), 440-444.
[] [PMID: 12203264]
Thoppil, R.J.; Harlev, E.; Mandal, A.; Nevo, E.; Bishayee, A. Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells. Pharm. Biol., 2013, 51(5), 668-674.
[] [PMID: 23368935]
Salla, M.; Fakhoury, I.; Saliba, N.; Darwiche, N.; Gali-Muhtasib, H. Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide. J. Nat. Med., 2013, 67(3), 468-479.
[] [PMID: 22976170]
Borrelli, F.; Romano, B.; Fasolino, I.; Tagliatatela-Scafati, O.; Aprea, G.; Capasso, R.; Capasso, F.; Coppola Bottazzi, E.; Izzo, A.A. Prokinetic effect of a standardized yarrow (Achillea millefolium) extract and its constituent choline: studies in the mouse and human stomach. Neurogastroenterol. Motil., 2012, 24(2), 164-171.
[] [PMID: 22151891]
Mouhid, L.; Gómez de Cedrón, M.; Vargas, T.; García-Carrascosa, E.; Herranz, N.; García-Risco, M.; Reglero, G.; Fornari, T.; Ramírez de Molina, A. Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts. BMC Complement. Altern. Med., 2018, 18(1), 254.
[] [PMID: 30223811]
Søgaard, K.K.; Farkas, D.K.; Pedersen, L.; Lund, J.L.; Thomsen, R.W.; Sørensen, H.T. Long-term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers. Cancer Med., 2016, 5(6), 1341-1351.
[] [PMID: 26923747]
Hansson, L.E.; Nyrén, O.; Hsing, A.W.; Bergström, R.; Josefsson, S.; Chow, W.H.; Fraumeni, J.F. Jr.; Adami, H.O. The risk of stom-ach cancer in patients with gastric or duodenal ulcer disease. N. Engl. J. Med., 1996, 335(4), 242-249.
[] [PMID: 8657240]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy