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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Review Article

Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies

Author(s): Pradeep Kumar*, Madhu Kamle, Dipendra K. Mahato, Himashree Bora, Bharti Sharma, Prasad Rasane and Vivek K. Bajpai

Volume 21, Issue 12, 2020

Page: [1165 - 1175] Pages: 11

DOI: 10.2174/1389201021666200430114547

Price: $65


Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, and phenolics. These compounds possess pharmacological properties, which make it anti-diabetic, antipyretic, anti-inflammatory, anti-oxidant, hepato-protective, and immuno-modulatory. However, due to the increasing population, there is an inadequate supply of drugs. Therefore, this review focuses on phytochemistry, ethnopharmacology, clinical application and its conservation strategies so that the plant can be conserved for future generations and utilized as alternative medicine as well as to design various pharmacologically important drugs.

Keywords: Tinospora cordifolia, Ayurveda, phytochemistry, ethnopharmacology, steroids, conservation strategies.

Graphical Abstract
Dash, V.B. Materia medica of Tibetan medicine; New; Delhi: Sri Satguru Publications, 1994.
Aima, R.K. Pictorial guide to plants; Natraj Publishers: Dehradun, 2003, pp. 454-455.
Khare, C.P. Indian medicinal plants: An illustrated dictionary; Springer Science & Business Media, 2008.
Kumar, V.; Nagar, S. Studies on Tinospora cordifolia monosugars and correlation analysis of uronic acids by spectrophotometric methods and GLC. Carbohydr. Polym., 2014, 99, 291-296.
[ ] [PMID: 24274509]
Bhandari, C.R. Vanaushadhi Chandrodaya; Chowkhamba Sanskrit Series Office, 1953.
Haque, M.A.; Jantan, I.; Abbas Bukhari, S.N. Tinospora species: An overview of their modulating effects on the immune system. J. Ethnopharmacol., 2017, 207, 67-85.
[ ] [PMID: 28629816]
API. The Ayurvedic Pharmacopoeia of India. Part I, 1st ed; Department Of AYUSH, Ministry of Health and FW: New Delhi,, 2001, Vol. 1, pp. 53-55.
Chopra, R.N.; Chopra, I.C. Indigenous drugs of India; Academic publishers, 1994.
Singh, S.S.; Pandey, S.C.; Srivastava, S.; Gupta, V.S.; Patro, B.; Ghosh, A.C. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Indian J. Pharmacol., 2003, 35(2), 83-91.
Mathew, S.; Kuttan, G. Immunomodulatory and antitumour activities of Tinospora cordifolia. Fitoterapia, 1999, 70(1), 35-43.
Bairy, K.L.; Roopa, K.; Malini, S.; Rao, C.M. Protective effect of Tinospora cordifolia on experimentally induced gastric ulcers in rats. J. Nat. Rem., 2002, 2(1), 49-53.
Agarwal, A.; Malini, S.; Bairy, K.L.; Rao, M.S. Effect of Tinospora cardifolia on learning and memory in normal and memory deficit rats. Indian J. Pharmacol., 2002, 34(5), 339-349.
Dhingra, D.; Goyal, P.K. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of Tinospora cordifolia in mice. Indian J. Pharm. Sci., 2008, 70(6), 761-767.
[ ] [PMID: 21369437]
Rao, P.R.; Kumar, V.K.; Viswanath, R.K.; Subbaraju, G.V. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol. Pharm. Bull., 2005, 28(12), 2319-2322.
[ ] [PMID: 16327173]
Gupta, R.S.; Sharma, A. Antifertility effect of Tinospora cordifolia (Willd.) stem extract in male rats. Indian J. Exp. Biol., 2003, 41(9), 885-889.
[PMID: 15242288]
Singh, R.P.; Banerjee, S.; Kumar, P.V.S.; Raveesha, K.A.; Rao, A.R. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine, 2006, 13(1-2), 74-84.
[ ] [PMID: 16360936]
Prince, P.S.M.; Menon, V.P.; Gunasekaran, G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J. Ethnopharmacol., 1998, 64(1), 53-57.
[ ] [PMID: 9533432]
Rawal, A.K.; Muddeshwar, M.G.; Biswas, S.K. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. BMC Complement. Altern. Med., 2004, 4(1), 11.
[ ] [PMID: 15310392]
Sharma, V.; Gupta, R.; Mishra, N.; Sharma, S. Influence of Tinospora cordifolia root extract supplementation on hematological and serological parameters of male mice exposed to aflatoxin B1. Int. J. Pharmacol., 2011, 7(5), 659-663.
Kumar, A.; Srivastava, S. Study of antipyretic activity of Guduchi sachitra. Ayurveda., 1995, 48, 289-291.
Prakash, S.; Rai, N.P. Role of T. cordifolia (Willd) Miers (Guduchi) in the treatment of infective hepatitis. J. Res. Ayurveda Siddha., 1996, 17, 58-68.
Sharma, P.C.; Yelne, M.B.; Dennis, T.J. Database on medicinal plants used in Ayurveda; CCRAS New Delhi, 2005, Vol. 3, .
Mittal, J.; Sharma, M.M.; Batra, A. Tinospora cordifolia: A multipurpose medicinal plant-A. Faslnamah-i Giyahan-i Daruyi, 2014, 2(2), 32-47.
Singh, H.; Mehta, M.; Khurana, N.; Sharma, N.; Vyas, M.; Singh, T.G.; Mahajan, S.; Satija, S. Recent patent technologies of Tinospora cordifolia for anti-diabetic potential: A review. Plant Arch., 2019, 19(2), 994-999.
Khosa, R.L.; Prasad, S. Pharmacognostical studies on Guduchi (Tinospora cordifolia Miers). J. Res. Indian Med., 1971, 6, 261-269.
Meshram, A.; Bhagyawant, S.S.; Gautam, S.; Shrivastava, N. Potential role of Tinospora cordifolia in pharmaceuticals. World J. Pharm. Sci., 2013, 2, 4615-4625.
Chintalwar, G.J.; Gupta, S.; Roja, G.; Bapat, V.A. Protoberberine alkaloids from callus and cell suspension cultures of Tinospora cordifolia. Pharm. Biol., 2003, 41(2), 81-86.
Maurya, R.; Manhas, L.R.; Gupta, P.; Mishra, P.K.; Singh, G.; Yadav, P.P.; Amritosides, A.; Amritosides, A. B, C and D: Clerodane furano diterpene glucosides from Tinospora cordifolia. Phytochemistry, 2004, 65(14), 2051-2055.
[ ] [PMID: 15279971]
Chintalwar, G.; Jain, A.; Sipahimalani, A.; Banerji, A.; Sumariwalla, P.; Ramakrishnan, R.; Sainis, K. An immunologically active arabinogalactan from Tinospora cordifolia. Phytochemistry, 1999, 52(6), 1089-1093.
[ ] [PMID: 10643671]
Ahmad, F.; Ali, M.; Alam, P. New phytoconstituents from the stem bark of Tinospora cordifolia Miers. Nat. Prod. Res., 2010, 24(10), 926-934.
[ ] [PMID: 20496230]
Upadhyay, A.K.; Kumar, K.; Kumar, A.; Mishra, H.S. Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies. Int. J. Ayurveda Res., 2010, 1(2), 112-121.
[ ] [PMID: 20814526]
Patel, S.S.; Shah, R.S.; Goyal, R.K. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J. Exp. Biol., 2009, 47(7), 564-570.
[PMID: 19761040]
Gupta, R.; Sharma, V. Ameliorative effects of tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-b(1) in mice kidney. Toxicol. Int., 2011, 18(2), 94-98.
[ ] [PMID: 21976812]
Jagetia, G.C.; Rao, S.K. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice. Biol. Pharm. Bull., 2006, 29(3), 460-466.
[ ] [PMID: 16508146]
Patel, M.B.; Mishra, S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine, 2011, 18(12), 1045-1052.
[ ] [PMID: 21665451]
Sharma, N.; Kumar, A.; Sharma, P.R.; Qayum, A.; Singh, S.K.; Dutt, P.; Paul, S.; Gupta, V.; Verma, M.K.; Satti, N.K.; Vishwakarma, R. A new clerodane furano diterpene glycoside from Tinospora cordifolia triggers autophagy and apoptosis in HCT-116 colon cancer cells. J. Ethnopharmacol., 2018, 211, 295-310.
[ ] [PMID: 28962889]
Sriramaneni, R.N.; Omar, A.Z.; Ibrahim, S.M.; Amirin, S.; Mohd Zaini, A. Vasorelaxant effect of diterpenoid lactones from Andrographis paniculata chloroform extract on rat aortic rings. Pharmacol. Res., 2010, 2(4), 242-246.
[ ] [PMID: 21808575]
Yang, S.; Evens, A.M.; Prachand, S.; Singh, A.T.K.; Bhalla, S.; David, K.; Gordon, L.I. Mitochondrial-mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata. Clin. Cancer Res., 2010, 16(19), 4755-4768.
[ ] [PMID: 20798229]
Zhao, F.; He, E-Q.; Wang, L.; Liu, K. Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level. J. Asian Nat. Prod. Res., 2008, 10(5-6), 467-473.
[ ] [PMID: 18464090]
Kohno, H.; Maeda, M.; Tanino, M.; Tsukio, Y.; Ueda, N.; Wada, K.; Sugie, S.; Mori, H.; Tanaka, T. A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. Cancer Lett., 2002, 183(2), 131-139.
[ ] [PMID: 12065087]
Dhanasekaran, M.; Baskar, A-A.; Ignacimuthu, S.; Agastian, P.; Duraipandiyan, V. Chemopreventive potential of epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. Invest. New Drugs, 2009, 27(4), 347-355.
[ ] [PMID: 18853103]
Ly, P.T.T.; Singh, S.; Shaw, C.A. Novel environmental toxins: steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases. J. Neurosci. Res., 2007, 85(2), 231-237.
[ ] [PMID: 17149752]
Chen, S.; Wu, K.; Knox, R. Structure-function studies of DT-diaphorase (NQO1) and NRH: Quinone oxidoreductase (NQO2). Free Radic. Biol. Med., 2000, 29(3-4), 276-284.
[ ] [PMID: 11035256]
Baldwin, A.S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest., 2001, 107(3), 241-246.
[ ] [PMID: 11160144]
Yang, J-H.; Kondratyuk, T.P.; Marler, L.E.; Qiu, X.; Choi, Y.; Cao, H.; Yu, R.; Sturdy, M.; Pegan, S.; Liu, Y.; Wang, L.Q.; Mesecar, A.D.; Van Breemen, R.B.; Pezzuto, J.M.; Fong, H.H.; Chen, Y.G.; Zhang, H.J. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry, 2010, 71(5-6), 641-647.
[ ] [PMID: 20100622]
Kim, S.K.; Kim, H.J.; Choi, S.E.; Park, K.H.; Choi, H.K.; Lee, M.W. Anti-oxidative and inhibitory activities on Nitric Oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg. Arch. Pharm. Res., 2008, 31(4), 424-428.
[ ] [PMID: 18449498]
Lv, J.; Xu, D.; Perkovic, V.; Ma, X.; Johnson, D.W.; Woodward, M.; Levin, A.; Zhang, H.; Wang, H.; Group, T.S. TESTING Study Group. Corticosteroid therapy in IgA nephropathy. J. Am. Soc. Nephrol., 2012, 23(6), 1108-1116.
[ ] [PMID: 22539830]
McKeown, E.; Bykerk, V.P.; De Leon, F.; Bonner, A.; Thorne, C.; Hitchon, C.A.; Boire, G.; Haraoui, B.; Ferland, D.S.; Keystone, E.C.; Pope, J.E. CATCH Investigators. Quality assurance study of the use of preventative therapies in glucocorticoid-induced osteoporosis in early inflammatory arthritis: results from the CATCH cohort. Rheumatology (Oxford), 2012, 51(9), 1662-1669.
[ ] [PMID: 22539481]
Sundarraj, S.; Thangam, R.; Sreevani, V.; Kaveri, K.; Gunasekaran, P.; Achiraman, S.; Kannan, S. γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J. Ethnopharmacol., 2012, 141(3), 803-809.
[ ] [PMID: 22440953]
Maurya, R.; Handa, S.S. Tinocordifolin, a sesquiterpene from Tinospora cordifolia. Phytochemistry, 1998, 49(5), 1343-1345.
de Oliveira, A.M.; Conserva, L.M.; de Souza Ferro, J.N.; de Almeida Brito, F.; Lyra Lemos, R.P.; Barreto, E. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. Int. J. Mol. Sci., 2012, 13(2), 1598-1611.
[ ] [PMID: 22408410]
Wang, T.; Liu, Y.Y.; Wang, X.; Yang, N.; Zhu, H.B.; Zuo, P.P. Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling. Acta Pharmacol. Sin., 2010, 31(7), 765-774.
[ ] [PMID: 20581854]
Thippeswamy, G.; Sheela, M.L.; Salimath, B.P. Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity. Eur. J. Pharmacol., 2008, 588(2-3), 141-150.
[ ] [PMID: 18513715]
Ghosh, A.K.; Chapsal, B.D.; Weber, I.T.; Mitsuya, H. Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance. Acc. Chem. Res., 2008, 41(1), 78-86.
[ ] [PMID: 17722874]
Mukherjee, R.; De, U.K.; Ram, G.C. Evaluation of mammary gland immunity and therapeutic potential of Tinospora cordifolia against bovine subclinical mastitis. Trop. Anim. Health Prod., 2010, 42(4), 645-651.
[ ] [PMID: 19876755]
Phan, V.K.; Chau, V.M.; Nguyen, T.D.; La, V.K.; Dan, T.H.; Nguyen, H.N.; Nguyen, X.C.; Hoang, T.H.; Trinh, V.L. Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia. Fitoterapia, 2010, 81(6), 485-489.
[ ] [PMID: 20080155]
Pan, L.; Terrazas, C.; Lezama-Davila, C.M.; Rege, N.; Gallucci, J.C.; Satoskar, A.R.; Kinghorn, A.D. Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia. Org. Lett., 2012, 14(8), 2118-2121.
[ ] [PMID: 22497272]
Sivasubramanian, A.; Gadepalli Narasimha, K.K.; Rathnasamy, R.; Campos, A.M.O. A new antifeedant clerodane diterpenoid from Tinospora cordifolia. Nat. Prod. Res., 2013, 27(16), 1431-1436.
[ ] [PMID: 22946632]
Naik, D.; Dandge, C.; Rupanar, S. Determination of chemical composition and evaluation of antioxidant activity of essential oil from Tinospora cordifolia (Willd.) Leaf. J. Essent. Oil-Bear. Plants, 2014, 17(2), 228-236.
Nair, P.K.R.; Melnick, S.J.; Ramachandran, R.; Escalon, E.; Ramachandran, C. Mechanism of macrophage activation by (1,4)-α-D-glucan isolated from Tinospora cordifolia. Int. Immunopharmacol., 2006, 6(12), 1815-1824.
[ ] [PMID: 17052672]
Hartley, I.E.; Liem, D.G.; Keast, R. umami as an ‘alimentary’ taste. A new perspective on taste classification. Nutrients, 2019, 11(1), 182.
[ ] [PMID: 30654496]
Sharma, P.; Srivastava, S.; Kumar, R.; Singh, V.B. Phytotherapy: An alternative low cost therapeutic management of endometritis in dairy animals: A review. Int. J. Curr. Microbiol. App. Sci., 2018, (7), 4581-4591.
Chakraborty, B.; Sengupta, M. Supporting the immune system through functional modulation of carbon tetrachloride intoxicated splenic macrophages by administering Tinospora cordifolia. J. Appl. Pharm. Sci., 2012, 2(7), 117.
Ranjith, M.S.; Ranjitsingh, A.J.A.; Shankar, S.G.; Vijayalaksmi, G.S.; Deepa, K.; Sidhu, H.S. Enhanced phagocytosis and antibody Production by Tinospora cordifolia-A new dimension in Immunomodulation.Afr. J. Biotechnol., 2008, 7(2), pp. 081-085.
Nagaraja, P.K.; Kammar, K.F.; Sheela, D.R. Efficacy of Tinospora cordifolia (Willd.) extracts on blood lipid profile in streptozotocin diabetic rats. Is it beneficial to the heart. Biomed. Res., 2008, 19(2), 92-96.
Stanely, P.; Prince, M.; Menon, V.P. Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats. J. Ethnopharmacol., 2000, 70(1), 9-15.
[ ] [PMID: 10720784]
Singh, J.; Sinha, K.; Sharma, A.; Mishra, N.P.; Khanuja, S.P. Traditional uses of Tinospora cordifolia (Guduchi). Curr. Res. Med. Aromat. Plants, 2003, 25, 748-751.
Kruger, C. Use of parts of the natural plant tinospora. W.O. Patent 0,087,50A1, June 1991.
Rohtangi, S. Ayurvedic composition for the prophylaxis and treatment of AIDS, flu, TB and other immuno-deficiencies and the process for preparing the same. U.S. Patent 6,043,045, June 25, 1996.
Chavali, S.R.; Forse, R.A. Formulation for alleviating symptoms associated with arthritis. U.S. Patent 08,691,865, 1997.
Mehrotra, R.; Katiyar, C.K.; Gupta, A.P. Hepatoprotective compositions and composition for treatment of conditions related to hepatitis B and E infection, U.S. Patent 6,136,316A, 2000.
Upadhyay, S.N.; Madan, V. Method for ex-vivo expansion of hematopoietic cells; Google Patents, 2001.
Sapna, B.; Rasendrakumar, J.; Dattatraya, Y. R. Use of Tinospora extract in the treatment of immune system-modulated disorders. EP, 1,345,615, 2001.
Sengupta, S.; Naskar, A.K.; Jana, M.; Naskar, P. Process for preparation of α-amylase from Tinospora cordifolia Miers useful for starch saccharification. U.S. Patent 6,379,721B1, 2002.
Palpu, P.; Mehrotra, S.; Rawat, A.K.S.; Khatoon, S.; Ojha, S.K.; Rastogi, S.; Srivastava, M.; Seth, P.K.; Agarwal, A.K.; Kakkar, P. Aurvedic herbal soft drink. U.S. Patent 0,147,554, 2006.
Singh, R.; Aravind, P.; Yogita, R. Herbal formulation comprising extracts of Withania, Tinospora and Picrorhiza as a pediatric tonic. WO Patent 0,147,554, 2006.
Ayare, S. Herbal compositions for effective treatment of aids, preparation thereof and method for treatment of aids patients., 2005.
Nair, P.K.R.; Melnick, S.J.; Ramachandran, C. Materials and methods for immune system stimulation; Google Patent 2008.U.S. Patent 7,425,548B2.
Vaidya, S.P. Formulation for prevention and treatment of bacterial infections and preparation thereof; Google Patents, 2013. U.S. Patent 8,445,033B2.
Patil, P.N. Herbal cattle feed supplement compositions for enhancing productivity and quality of milk; Google Patents, 2014. WO Patent 2,011,045801.
Chatterji, A.K. Preparation for weight loss management; Google Patents, 2015.WO Patent 1,393,54A1, 2011.
Rosen, B.D. Alternative ACT with natural botanical active GRAS ingredients for treatment and prevention of the Zika virus; Google Patents, 2017. U.S. Patent 9,6755,82B2.
Sangeetha, M.K.; Balaji Raghavendran, H.R.; Gayathri, V.; Vasanthi, H.R. Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. J. Nat. Med., 2011, 65(3-4), 544-550.
[ ] [PMID: 21538233]
Sharma, V.; Pandey, D. Protective role of Tinospora cordifolia against lead-induced hepatotoxicity. Toxicol. Int., 2010, 17(1), 12-17.
[ ] [PMID: 21042467]
Sharma, V.; Pandey, D. Beneficial effects of Tinospora cordifolia on blood profiles in male mice exposed to lead. Toxicol. Int., 2010, 17(1), 8-11.
[ ] [PMID: 21042466]
Chopra, A.; Saluja, M.; Tillu, G.; Venugopalan, A.; Narsimulu, G.; Handa, R.; Bichile, L.; Raut, A.; Sarmukaddam, S.; Patwardhan, B. Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled study. Clin. Rheumatol., 2012, 31(2), 259-269.
[ ] [PMID: 21773714]
Abiramasundari, G.; Sumalatha, K.R.; Sreepriya, M. Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro. J. Ethnopharmacol., 2012, 141(1), 474-480.
[ ] [PMID: 22449439]
Gao, L.; Cai, G.; Shi, X. β-ecdysterone induces osteogenic differentiation in mouse mesenchymal stem cells and relieves osteoporosis. Biol. Pharm. Bull., 2008, 31(12), 2245-2249.
[ ] [PMID: 19043207]
Kapur, P.; Wuttke, W.; Jarry, H.; Seidlova-Wuttke, D. Beneficial effects of β-Ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats. Phytomedicine, 2010, 17(5), 350-355.
[ ] [PMID: 20171072]
Kalikar, M.V.; Thawani, V.R.; Varadpande, U.K.; Sontakke, S.D.; Singh, R.P.; Khiyani, R.K. Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients. Indian J. Pharmacol., 2008, 40(3), 107-110.
[ ] [PMID: 20040936]
Akhtar, S. Use of Tinospora cordifolia in HIV infection. Indian J. Pharmacol., 2010, 42(1), 57.
[ ] [PMID: 20606842]
Sharma, P.; Parmar, J.; Verma, P.; Goyal, P. K. Radiation-induced testicular injury and its amelioration by Tinospora cordifolia (An Indian medicinal plant) extract. Evid.-Based Complementary Altern. Med., 2011, 2011.
Rao, S.K.; Rao, P.S. Alteration in the radiosensitivity of HeLa cells by dichloromethane extract of guduchi (Tinospora cordifolia). Integr. Cancer Ther., 2010, 9(4), 378-384.
[ ] [PMID: 21106617]
Kapur, P.; Pereira, B.M.J.; Wuttke, W.; Jarry, H. Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP. Phytomedicine, 2009, 16(6-7), 679-682.
[ ] [PMID: 19097771]
Javir, G.; Joshi, K. Evaluation of the combinatorial effect of Tinospora cordifolia and Zingiber officinale on human breast cancer cells. 3 Biotech., 2019, 9(11), 428.
Narayanan, A.S.; Raja, S.S.; Ponmurugan, K.; Kandekar, S.C.; Natarajaseenivasan, K.; Maripandi, A.; Mandeel, Q.A. Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India. Benef. Microbes, 2011, 2(3), 235-243.
[ ] [PMID: 21986363]
Jeyachandran, R.; Xavier, T.F.; Anand, S.P. Antibacterial activity of stem extracts of Tinospora cordifolia (Willd) Hook. f & Thomson. Anc. Sci. Life, 2003, 23(1), 40-43.
[PMID: 22557111]
Tambekar, D.H.; Khante, B.S.; Chandak, B.R.; Titare, A.S.; Boralkar, S.S.; Aghadte, S.N. Screening of antibacterial potentials of some medicinal plants from Melghat forest in India. Afr. J. Tradit. Complement. Altern. Med., 2009, 6(3), 228-232.
[PMID: 20448847]
Thatte, U.M.; Kulkarni, M.R.; Dahanukar, S.A. Immunotherapeutic modification of Escherichia coli peritonitis and bacteremia by Tinospora cordifolia. J. Postgrad. Med., 1992, 38(1), 13-15.
[PMID: 1512717]
Sengupta, S.; Mukherjee, A.; Goswami, R.; Basu, S. Hypoglycemic activity of the antioxidant saponarin, characterized as α-glucosidase inhibitor present in Tinospora cordifolia. J. Enzyme Inhib. Med. Chem., 2009, 24(3), 684-690.
[ ] [PMID: 18951283]
Sengupta, M.; Sharma, G.D.; Chakraborty, B. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC Complement. Altern. Med., 2011, 11(1), 102.
[ ] [PMID: 22035196]
Purandare, H.; Supe, A. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study. Indian J. Med. Sci., 2007, 61(6), 347-355.
[ ] [PMID: 17558098]
Sarkar, S.B.K.; Padhi, M.M.; Vasanthakumar, K.G.; Verma, S.C.; Deep, V.C. Evaluation of Antimicrobial Potential of Traditional Formulation Giloy Satva; National Research Institute for Panchakarma, Kerala And Central Council for Research in Ayurvedic Sciences, Department of AYUSH: New Delhi, India, 2013.
Sivakumar, V.; Rajan, M.S.D. Antioxidant effect of Tinospora cordifolia extract in alloxan-induced diabetic rats. Indian J. Pharm. Sci., 2010, 72(6), 795-798.
[ ] [PMID: 21969757]
Gacche, R.N.; Dhole, N.A. Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications. Food Chem. Toxicol., 2011, 49(8), 1806-1813.
[ ] [PMID: 21570444]
Rawal, A.; Muddeshwar, M.; Biswas, S. Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochem. Biophys. Res. Commun., 2004, 324(2), 588-596.
[ ] [PMID: 15474468]
Khan, M.I.; Harsha, P.S.; Giridhar, P.; Ravishankar, G.A. Pigment identification, antioxidant activity, and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms fruit. Int. J. Food Sci. Nutr., 2011, 62(3), 239-249.
[ ] [PMID: 21155657]
Shivananjappa, M.M. Muralidhara, Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia. Nutrition, 2012, 28(5), 581-587.
[ ] [PMID: 22189193]
Prince, P.S.; Kamalakkannan, N.; Menon, V.P. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats. Acta Pol. Pharm., 2004, 61(4), 283-287.
[PMID: 15575595]
Sarma, D.N.K.; Khosa, R.L.; Chansauria, J.P.N.; Sahai, M. Antistress activity of Tinospora cordifolia and Centella asiatica extracts. Phytother. Res., 1996, 10(2), 181-183.
[<181: AID-PTR804>3.0.CO;2-6]
Kulkarni, S.K.; Verma, A. BR-16A (MENTAT [R]), A herbal preparation, improves learning and memory performance in mice. Indian Drugs-Bombay., 1993, 30, 97-97.
Mishra, R.; Manchanda, S.; Gupta, M.; Kaur, T.; Saini, V.; Sharma, A.; Kaur, G. Tinospora cordifolia ameliorates anxiety-like behavior and improves cognitive functions in acute sleep deprived rats. Sci. Rep., 2016, 6, 25564.
[ ] [PMID: 27146164]
Sarma, D.N.K.; Khosa, R.L.; Chansauria, J.P.N.; Sahai, M. Antiulcer activity of Tinospora cordifolia Miers and Centella asiatica Linn extracts. Phytother. Res., 1995, 9(8), 589-590.
Kaur, M.; Singh, A.; Kumar, B. Comparative antidiarrheal and antiulcer effect of the aqueous and ethanolic stem bark extracts of Tinospora cordifolia in rats. J. Adv. Pharm. Technol. Res., 2014, 5(3), 122-128.
[ ] [PMID: 25126533]
Raghu, R.; Sharma, D.; Ramakrishnan, R.; Khanam, S.; Chintalwar, G.J.; Sainis, K.B. Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia. Immunol. Lett., 2009, 123(1), 60-71.
[ ] [PMID: 19428553]
Bala, M.; Pratap, K.; Verma, P.K.; Singh, B.; Padwad, Y. Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC. J. Ethnopharmacol., 2015, 175, 131-137.
[ ] [PMID: 26253577]
Gupta, P.K.; Rajan, M.G.R.; Kulkarni, S. Activation of murine macrophages by G1-4A, a polysaccharide from Tinospora cordifolia, in TLR4/MyD88 dependent manner. Int. Immunopharmacol., 2017, 50, 168-177.
[ ] [PMID: 28667885]
Shefali, C.; Nilofer, S. Gaduchi-The Best Ayurvedic Herb. Pharma Innovation., 2013, 2(4, Part A), 97.
Raghu, A.V.; Geetha, S.P.; Martin, G.; Balachandran, I.; Ravindran, P.N. In vitro clonal propagation through mature nodes of Tinospora cordifolia (Willd.) Hook. F. & Thoms.: An important ayurvedic medicinal plant. In Vitro Cell. Dev. Biol. Plant, 2006, 42(6), 584-588.
Handique, P.J.; Sharma, D. Micropropagation of Stephania japonica, a rare medicinal plant of north-east India. J. Hill Agric., 2010, 1(2), 102-106.
Meena, M.K.; Singh, N.; Patni, V. In vitro multiple shoot induction through axillary bud of Cocculus hirsutus (L.) Diels: A threatened medicinal plant. Afr. J. Biotechnol., 2012, 11(12), 2952-2956.

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