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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Jaceosidin: A Natural Flavone with Versatile Pharmacological and Biological Activities

Author(s): Bushra Nageen, Azhar Rasul*, Ghulam Hussain, Muhammad A. Shah*, Haseeb Anwar, Syed M. Hussain, Md. Sahab Uddin, Iqra Sarfraz, Ammara Riaz and Zeliha Selamoglu

Volume 27, Issue 4, 2021

Published on: 29 April, 2020

Page: [456 - 466] Pages: 11

DOI: 10.2174/1381612826666200429095101


Nature always remains an inexhaustible source of treasures for mankind. It remains a mystery for every challenge until the completion of the challenge. While we talk about the complicated health issues, nature offers us a great variety of chemical scaffolds and their various moieties packed in the form of natural products e.g., plants, microorganisms (fungi, algae, protozoa), and terrestrial vertebrates and invertebrates. This review article is an update about jaceosidin, a bioactive flavone, from genus Artemisia. This potentially active compound exhibits a variety of pharmacological activities including anti-inflammatory, anti-oxidant, anti-bacterial, antiallergic and anti-cancer activities. The bioactivities and the therapeutic action of jaceosidin, especially the modulation of different cell signaling pathways (ERK1/2, NF-κB, PI3K/Akt and ATM-Chk1/2) which become deregulated in various pathological disorders, have been focused here. The reported data suggest that the bioavailability of this anti-cancer compound should be enhanced by utilizing various chemical, biological and computational techniques. Moreover, it is recommended that researchers and scientists should work on exploring the mode of action of this particular flavone to precede it further as a potent anti-cancer compound.

Keywords: Jaceosidin, natural products, antioxidant, anti-inflammatory, anti-cancer, anti-mutagenic.

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