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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Isoquinolines: Important Cores in Many Marketed and Clinical Drugs

Author(s): Chunying Luo, Maxwell Ampomah-Wireko, Huanhuan Wang, Chunli Wu*, Qing Wang, Hui Zhang and Yaquan Cao

Volume 21 , Issue 7 , 2021

Published on: 24 April, 2020

Page: [811 - 824] Pages: 14

DOI: 10.2174/1871520620666200424132248

Price: $65


Background: Isoquinoline analogs are an important, structurally diverse class of compounds that are extensively used as pharmaceuticals. Derivatives containing the isoquinoline scaffold have become a focus of therapeutic research because of their wide range of biological characteristics. Examples of these drugs, many of which are in clinical application or at the pre-clinical stage, are used to treat a broad swathe of ailments, such as tumors, respiratory diseases, infections, nervous system diseases, cardiovascular and cerebrovascular diseases, endocrine and metabolic diseases.

Methods: Data were collected from PubMed, Web of Science, and SciFinder, through searches of drug names.

Results: At least 38 isoquinoline-based therapeutic drugs are in clinical application or clinical trials, and their chemical structure and pharmacokinetics are described in detail.

Conclusion: The isoquinoline ring is a privileged scaffold which is often preferred as a structural basis for drug design, and plays an important role in drug discovery. This review provides a guide for pharmacologists to find effective preclinical/clinical drugs and examines recent progress in the application of the isoquinoline scaffold.

Keywords: Isoquinoline, clinical drug, disease, chemical property, pharmacology, activity.

Graphical Abstract
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