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Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Meta-Analysis

Novel Streptomyces Sp. Reported in 2018: A Meta-Analysis

Author(s): Sagar Aryal*, Laxmi Neupane, Rameshwar Adhikari, Balmukunda Regmi, Niranjan Koirala and Dev Raj Joshi

Volume 19 , Issue 5 , 2021

Published on: 22 April, 2020

Article ID: e030921181212 Pages: 12

DOI: 10.2174/2211352518666200423083354

Price: $65

Abstract

Streptomyces species are very well known for the production of antimicrobials and enzymes. The objective of this review was to search for the novel Streptomyces isolated in 2018 along with their characteristics and possible antimicrobial properties. The literature search was done according to the PRISMA flow diagram, where 28 research papers were eligible for the review. Data entry and analyses were performed using IBM SPSS Statistics version 25, while the phylogenetic tree was constructed using Geneious Prime Software. The data on general characteristics, biochemical as well as sugar fermentation tests, 16S rRNA gene sequence similarity and DNA-DNA hybridization relatedness were extracted from the research papers and summarized in tables and figures. The biosynthesis gene cluster (BGC) was identified using ‘antibiotics and secondary metabolite analysis shell-antiSMASH’, which showed the possibility of production of new antibiotics, antifungal and antitumor substances from the 28 novel Streptomyces isolated in 2018 which would contribute to the global effort to fight against growing multidrug-resistance.

Keywords: Streptomyces, novel, antimicrobials, anti-infective, biosynthesis gene cluster, meta-analysis.

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