Login Register Cart 0
Generic placeholder image

Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Meta-Analysis

A Systematic Review and Meta-Analysis of Serotype Distribution of Streptococcus Pneumoniae in Iran: Practical Evidence to Optimizing Local Vaccination Protocols

Author(s): Abdollah Karimi, Seyedeh Mahsan Hoseini-Alfatemi and Sedigheh Rafiei Tabatabaei*

Volume 21, Issue 2, 2021

Published on: 20 April, 2020

Page: [304 - 310] Pages: 7

DOI: 10.2174/1871526519666191002142953

Price: $65

Abstract

Background: Little is known regarding the burden of predominant circulating serotypes of Streptococcus pneumoniae in Iran. Therefore, this study aimed to investigate the serotype distribution of pneumococcal diseases in Iran by using a comprehensive systematic review of available articles.

Methods: A systematic literature search was carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, Embase and Google Scholar electronic databases from January 2000 to December 2018. Then, eight publications that met our inclusion criteria were selected for data extraction and analysis by Comprehensive Meta-Analysis software.

Results: In total, three studies reported the distribution of S. pneumoniae serotypes among patients, two studies among healthy individuals, and three studies among both groups. Of those studies, serotype 19A/F (17.9%; 95% CI: 13.6-23.0) was the most circulating serotype followed by 23A/F (12.3%; 95% CI: 7.7-19.2), 6A/B (11.0%; 95% CI: 8.0-14.9), and 14 (8.8%; 95% CI: 5.8-13.2). In contrast, the lowest circulating serotype was 60 (0.02%; 95% CI: 0.0-1.2), 29 (0.07%; 95% CI: 0.01-5.0), and 36 (0.09%; 95% CI: 0.04-2.1). Meta-regression results showed that prevalence of serotype 23A/F significantly increased each year about 0.2% (95% CI: 0.1-0.3, P <0.001, tau2 <0.001).

Conclusion: In the present study, it was found that over the last decade, the most prevalent serotypes in Iran were 19, 23, 6, and 14, respectively. These findings provide practical evidence to select effective pneumococcal vaccine candidates for the prevention of invasive diseases in Iranian patients and also to compare our situation with others.

Keywords: Streptococcus pneumoniae, polysaccharide capsule, serotype, vaccine, pneumococcal, invasive diseases.

Graphical Abstract

[1]
Henriques-Normark, B.; Tuomanen, E.I. The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb. Perspect. Med., 2013, 3(7), a010215.
[http://dx.doi.org/10.1101/cshperspect.a010215] [PMID: 23818515]
[2]
Mirsaeidi, M.; Ebrahimi, G.; Allen, M.B.; Aliberti, S. Pneumococcal vaccine and patients with pulmonary diseases. Am. J. Med., 2014, 127(9), 886.e1-886.e8.
[http://dx.doi.org/10.1016/j.amjmed.2014.05.010] [PMID: 24852934]
[3]
Berical, A.C.; Harris, D.; Dela Cruz, C.S.; Possick, J.D. Pneumococcal Vaccination Strategies. An Update and Perspective. Ann. Am. Thorac. Soc., 2016, 13(6), 933-944.
[http://dx.doi.org/10.1513/AnnalsATS.201511-778FR] [PMID: 27088424]
[4]
Shenoy, A.T.; Orihuela, C.J. Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan), 2016. 8, 7.
[5]
Motamedifar, M.; Sedigh Ebrahim-Saraie, H.; Mansury, D.; Nikokar, I.; Hashemizadeh, Z. Prevalence of Etiological Agents and Antimicrobial Resistance Patterns of Bacterial Meningitis in Nemazee Hospital, Shiraz, Iran. Arch. Clin. Infect. Dis., 2015, 10(2), e22703.
[http://dx.doi.org/10.5812/archcid.10(2)2015.22703]
[6]
Tan, T.Q. Pediatric invasive pneumococcal disease in the United States in the era of pneumococcal conjugate vaccines. Clin. Microbiol. Rev., 2012, 25(3), 409-419.
[http://dx.doi.org/10.1128/CMR.00018-12] [PMID: 22763632]
[7]
Rudan, I.; Boschi-Pinto, C.; Biloglav, Z.; Mulholland, K.; Campbell, H. Epidemiology and etiology of childhood pneumonia. Bull. World Health Organ., 2008, 86(5), 408-416.
[http://dx.doi.org/10.2471/BLT.07.048769] [PMID: 18545744]
[8]
Geno, K.A.; Gilbert, G.L.; Song, J.Y.; Skovsted, I.C.; Klugman, K.P.; Jones, C.; Konradsen, H.B.; Nahm, M.H. Pneumococcal Capsules and Their Types: Past, Present, and Future. Clin. Microbiol. Rev., 2015, 28(3), 871-899.
[http://dx.doi.org/10.1128/CMR.00024-15] [PMID: 26085553]
[9]
Wang, Y.; Li, J.; Wang, Y.; Gu, W.; Zhu, F. Effectiveness and practical uses of 23-valent pneumococcal polysaccharide vaccine in healthy and special populations. Hum. Vaccin. Immunother., 2018, 14(4), 1003-1012.
[http://dx.doi.org/10.1080/21645515.2017.1409316] [PMID: 29261406]
[10]
Johnson, H.L.; Deloria-Knoll, M.; Levine, O.S.; Stoszek, S.K.; Freimanis Hance, L.; Reithinger, R.; Muenz, L.R.; O’Brien, K.L. Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project. PLoS Med., 2010, 7(10), e1000348.
[http://dx.doi.org/10.1371/journal.pmed.1000348] [PMID: 20957191]
[11]
Mousavi, S.F.; Nobari, S.; Rahmati Ghezelgeh, F.; Lyriai, H.; Jalali, P.; Shahcheraghi, F.; Oskoui, M. Serotyping of Streptococcus pneumoniae isolated from Tehran by Multiplex PCR: Are serotypes of clinical and carrier isolates identical? Iran. J. Microbiol., 2013, 5(3), 220-226.
[PMID: 24475327]
[12]
Theodoridou, M.N.; Vasilopoulou, V.A.; Atsali, E.E.; Pangalis, A.M.; Mostrou, G.J.; Syriopoulou, V.P. Meningitis registry of hospitalized cases in children: epidemiological patterns of acute bacterial meningitis throughout a 32-year period. BMC Infect Dis, 2007, 7, 101.
[13]
Stockmann, C.; Ampofo, K.; Byington, C.L.; Filloux, F.; Hersh, A.L.; Blaschke, A.J.; Cowan, P.; Korgenski, K.; Mason, E.O.; Pavia, A.T. Pneumococcal meningitis in children: epidemiology, serotypes, and outcomes from 1997-2010 in Utah. Pediatrics, 2013, 132(3), 421-428.
[http://dx.doi.org/10.1542/peds.2013-0621] [PMID: 23979090]
[14]
Chen, Y.; Deng, W.; Wang, S.M.; Mo, Q.M.; Jia, H.; Wang, Q.; Li, S.G.; Li, X.; Yao, B.D.; Liu, C.J.; Zhan, Y.Q.; Ji, C.; Lopez, A.L.; Wang, X.Y. Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review. PLoS One, 2011, 6(11), e27333.
[http://dx.doi.org/10.1371/journal.pone.0027333] [PMID: 22110628]
[15]
Silva-Costa, C.; Brito, M.J.; Aguiar, S.I.; Lopes, J.P.; Ramirez, M.; Melo-Cristino, J. Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015). Sci. Rep., 2019, 9(1), 6.
[http://dx.doi.org/10.1038/s41598-018-36799-x] [PMID: 30626918]
[16]
Iroh Tam, P.Y.; Madoff, L.C.; Coombes, B.; Pelton, S.I. Invasive pneumococcal disease after implementation of 13-valent conjugate vaccine. Pediatrics, 2014, 134(2), 210-217.
[http://dx.doi.org/10.1542/peds.2014-0473] [PMID: 25002663]
[17]
Ladhani, S.N.; Collins, S.; Djennad, A.; Sheppard, C.L.; Borrow, R.; Fry, N.K.; Andrews, N.J.; Miller, E.; Ramsay, M.E. Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000-17: a prospective national observational cohort study. Lancet Infect. Dis., 2018, 18(4), 441-451.
[http://dx.doi.org/10.1016/S1473-3099(18)30052-5] [PMID: 29395999]
[18]
Usuf, E.; Bottomley, C.; Bojang, E.; Cox, I.; Bojang, A.; Gladstone, R. Persistence of nasopharyngeal pneumococcal vaccine serotypes and increase of non-vaccine serotypes among vaccinated infants and their mothers five years after PCV13 introduction in The Gambia. Clin. Infect. Dis., 2018, 68(9), 1512-1521.
[19]
Ubukata, K.; Takata, M.; Morozumi, M.; Chiba, N.; Wajima, T.; Hanada, S.; Shouji, M.; Sakuma, M.; Iwata, S. Invasive Pneumococcal Diseases Surveillance Study Group. Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010-2017. Emerg. Infect. Dis., 2018, 24(11), 2010-2020.
[http://dx.doi.org/10.3201/eid2411.180326] [PMID: 30334707]
[20]
von Elm, E.; Altman, D.G.; Egger, M.; Pocock, S.J.; Gøtzsche, P.C.; Vandenbroucke, J.P. STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J. Clin. Epidemiol., 2008, 61(4), 344-349.
[http://dx.doi.org/10.1016/j.jclinepi.2007.11.008] [PMID: 18313558]
[21]
Houri, H.; Tabatabaei, S.R.; Saee, Y.; Fallah, F.; Rahbar, M.; Karimi, A. Distribution of capsular types and drug resistance patterns of invasive pediatric Streptococcus pneumoniae isolates in Teheran, Iran. Int J Infect Dis, 2017, 57, 21-26.
[22]
Moghadam, M.S.; Talebi, M.; Masjedian, F.; Irajian, G.; Pourshafie, M.R. Streptococcus pneumoniae serotyping by a single polymerase chain reaction-based multiplex assay. Infect. Dis. Clin. Pract., 2018, 26(2), 75-79.
[http://dx.doi.org/10.1097/IPC.0000000000000554]
[23]
Gharailoo, Z.; Mousavi, S.F.; Halvani, N.; Feizabadi, M.M. Antimicrobial Resistant Pattern and Capsular Typing of Streptococcus Pneumoniae Isolated from Children in Sistan -Baluchestan. Maedica (Buchar.), 2016, 11(3), 203-207.
[PMID: 28694854]
[24]
Hajia, M.; Rahbar, M.; Rahnami Farzami, M.; Dolatyar, A.; Imani, M.; Saburian, R.; Farzanehkhah, M. Efficacy of multiplex PCR procedure for Iranian Streptococcus pneumoniae isolates. Caspian J. Intern. Med., 2014, 5(2), 109-113.
[PMID: 24778787]
[25]
Mehrabi Tavana, A.; Ataee, R.A. Invasive Pneumococcal Disease (IPD) Serotype Frequency in Iranian Patients. Iran. Red Crescent Med. J., 2013, 15(8), 740-742.
[http://dx.doi.org/10.5812/ircmj.4145] [PMID: 24578845]
[26]
Sanaei Dashti, A.; Abdinia, B.; Karimi, A. Nasopharyngeal carrier rate of Streptococcus pneumoniae in children: serotype distribution and antimicrobial resistance. Arch. Iran Med., 2012, 15(8), 500-503.
[PMID: 22827788]
[27]
Bokaeian, M.; Khazaei, H.A.; Javadimehr, M. Nasopharyngeal Carriage, Antibiotic Resistance and Serotype Distribution of Streptococcus Pneumoniae among Healthy Adolescents in Zahedan. Iran. Red Crescent Med. J., 2011, 13(5), 328-333.
[PMID: 22737489]
[28]
Greenberg, D.; Hoover, P.A.; Vesikari, T.; Peltier, C.; Hurley, D.C.; McFetridge, R.D.; Dallas, M.; Hartzel, J.; Marchese, R.D.; Coller, B.G.; Stek, J.E.; Abeygunawardana, C.; Winters, M.A.; MacNair, J.E.; Pujar, N.S.; Musey, L. Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV15) in healthy infants. Vaccine, 2018, 36(45), 6883-6891.
[http://dx.doi.org/10.1016/j.vaccine.2018.02.113] [PMID: 30244873]
[29]
Lyu, S.; Hu, H.L.; Yang, Y.H.; Yao, K.H. A systematic review about Streptococcus Pneumoniae serotype distribution in children in mainland of China before the PCV13 was licensed. Expert Rev. Vaccines, 2017, 16(10), 997-1006.
[http://dx.doi.org/10.1080/14760584.2017.1360771] [PMID: 28745918]
[30]
Al-Sheikh, Y.A.; K Gowda, L.; Mohammed Ali, M.M.; John, J.; Khaled Homoud Mohammed, D.; Chikkabidare Shashidhar, P. Distribution of serotypes and antibiotic susceptibility patterns among invasive pneumococcal diseases in Saudi Arabia. Ann. Lab. Med., 2014, 34(3), 210-215.
[http://dx.doi.org/10.3343/alm.2014.34.3.210] [PMID: 24790908]
[31]
Soh, S.W.; Poh, C.L.; Lin, R.V. Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from pediatric patients in Singapore. Antimicrob. Agents Chemother., 2000, 44(8), 2193-2196.
[http://dx.doi.org/10.1128/AAC.44.8.2193-2196.2000] [PMID: 10898701]
[32]
Srifeungfung, S.; Phongsamart, W.; Tribuddharat, C.; Chatsuwan, T.; Rungnobhakhun, P.; Sapcharoen, S.; Chokephaibulkit, K. Serotype distribution and antibiotic susceptibility of invasive Streptococcus pneumoniae isolates in patients aged 50 years or older in Thailand. Hum. Vaccin. Immunother., 2014, 10(1), 40-44.
[http://dx.doi.org/10.4161/hv.26418] [PMID: 24030588]
[33]
Ceyhan, M.; Ozsurekci, Y.; Gürler, N.; Öksüz, L.; Aydemir, S.; Ozkan, S.; Yuksekkaya, S.; Keser Emiroglu, M.; Gültekin, M.; Yaman, A.; Kiremitci, A.; Yanık, K.; Karli, A.; Ozcinar, H.; Aydin, F.; Bayramoglu, G.; Zer, Y.; Gulay, Z.; Gayyurhan, E.D.; Gül, M.; Özakın, C.; Güdücüoğlu, H.; Perçin, D.; Akpolat, N.; Ozturk, C.; Camcıoğlu, Y.; Karadağ Öncel, E.; Çelik, M.; Şanal, L.; Uslu, H. Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014. Hum. Vaccin. Immunother., 2016, 12(2), 308-313.
[http://dx.doi.org/10.1080/21645515.2015.1078952] [PMID: 26325175]
[34]
Tyrrell, G.J. The changing epidemiology of Streptococcus pneumoniae serotype 19A clonal complexes. J. Infect. Dis., 2011, 203(10), 1345-1347.
[http://dx.doi.org/10.1093/infdis/jir056] [PMID: 21398394]
[35]
Bewick, T.; Sheppard, C.; Greenwood, S.; Slack, M.; Trotter, C.; George, R.; Lim, W.S. Serotype prevalence in adults hospitalised with pneumococcal non-invasive community-acquired pneumonia. Thorax, 2012, 67(6), 540-545.
[http://dx.doi.org/10.1136/thoraxjnl-2011-201092] [PMID: 22374921]
[36]
Imöhl, M.; Reinert, R.R.; Ocklenburg, C.; van der Linden, M. Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal disease. J. Clin. Microbiol., 2010, 48(4), 1291-1296.
[http://dx.doi.org/10.1128/JCM.01937-09] [PMID: 20107087]

Rights & Permissions Print Cite
Article Metrics
37
© 2024 Bentham Science Publishers | Privacy Policy