Squamous Cell (SQC) is a rare type among gallbladder cancer (GBC) and it has a very poor prognosis due to frequent local invasion and advanced stage at diagnosis. Its clinical course and prognostic factors have not been known well until now. The aim of this report is to present an unresectable SQC-GBC case treated by Concurrent Chemo-Radiation Treatment (CCRT) and compare the results of treatment with previously reported case series.
This is a case report of a 57 years old female patient, diagnosed with unresectable primary pure SQC of GBC with bile duct invasion and multiple liver and lymph node metastases. She underwent CCRT with best supportive care (BSC), including percutaneous and endoscopic drainage of malignant biliary obstruction, and partial response was achieved. However, the patient was expired due to metastatic invasion of colon and uterus in 10 months after first diagnosis.
Keywords: Gallbladder cancer, Squamous cell cancer, Percutaneous transhepatic, Biliary drainage, Endoscopic retrograde cholangiopancreatography, EUS-guided gallbladder drainage, Chemo-radiotherapy, Supportive care.