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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Drug Delivery Systems Using Surface Markers for Targeting Cancer Stem Cells

Author(s): James T. Oswald*, Haritosh Patel, Daid Khan, Ninweh N. Jeorje, Hossein Golzar, Erin L. Oswald and Shirley Tang

Volume 26 , Issue 17 , 2020

Page: [2057 - 2071] Pages: 15

DOI: 10.2174/1381612826666200406084900

Price: $65


The innate abilities of cancer stem cells (CSCs), such as multi-drug resistance, drug efflux, quiescence and ionizing radiation tolerance, protect them from most traditional chemotherapeutics. As a result, this small subpopulation of persistent cells leads to more aggressive and chemoresistant cancers, causing tumour relapse and metastasis. This subpopulation is differentiated from the bulk tumour population through a wide variety of surface markers expressed on the cell surface. Recent developments in nanomedicine and targeting delivery methods have given rise to new possibilities for specifically targeting these markers and preferentially eliminating CSCs. Herein, we first summarize the range of surface markers identifying CSC populations in a variety of cancers; then, we discuss recent attempts to actively target CSCs and their niches using liposomal, nanoparticle, carbon nanotube and viral formulations.

Keywords: Cancer Stem Cells (CSC), nanoparticles, targeted delivery, stem cell surface markers, liposomes, surface markers.

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