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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Chalcones: Retrospective Synthetic Approaches and Mechanistic Aspects of a Privileged Scaffold

Author(s): Emília P.T. Leitão*

Volume 26, Issue 24, 2020

Page: [2843 - 2858] Pages: 16

DOI: 10.2174/1381612826666200403124259

Price: $65

Abstract

This review summarizes the synthetic methodologies used in the last 25 years for the synthesis of chalcones, which are a class of flavonoids having a 1,3-diphenyl-2-propene-1-one backbone. These compounds are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because they are important precursors for the synthesis of heterocyclic compounds with therapeutic applications such as: flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.

Keywords: Chalcones, scaffold, medicinal chemistry, pharmacological activity, flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines, pyrazolines derivatives.

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