Abstract
It is now well accepted that colon cancer evolves from a multi-step process and is a disease strongly influenced by environmental factors, with diet being one of the most important modifying agents. Among dietary factors, there is cogent evidence indicating a protective effect of fish oil feeding with respect to colonic tumor development. We have recently demonstrated that the balance between colonic epithelial cell proliferation and programmed cell death (apoptosis) can be favorably modulated by feeding fish oil, containing n-3 polyunsaturated fatty acids, specifically, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We propose that the suppression of colonic tumor development by dietary n-3 polyunsaturated fatty acids may be due to an effect on the subcellular localization of oncogenic p21 ras. The potential for fish oil feeding to antagonize ras-dependent signal transduction is significant because the acquisition of chronically activated ras via mutation or overexpression is a relatively early step in colorectal cancer development.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
N-Heterocyclics: Synthesis, Computational Studies, and Coordination Chemistry - A synthetic perspective
N-heterocycles, such as phenanthroline, quinoline, or their organometallic complexes, are widely used in a variety of fields, including chemistry, biochemistry, and coordination chemistry. They play a key role in many chemical and biological processes as biological ligands, medicinal agents, catalysts in organic synthesis, molecular probes and sensors, as well as ...read more
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