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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

DNA Polymerase Structure and Mechanisms of Action

Author(s): Manju M. Hingorani and Mike O'Donne

Volume 4, Issue 9, 2000

Page: [887 - 913] Pages: 27

DOI: 10.2174/1385272003375996

Price: $65


The ubiquitous and essential nature of DNA predicts that enzymes responsible for DNA synthesis evolved early and share a common design and mechanism of action. DNA polymerases from many different organisms do exhibit striking similarities in their overall architecture, the design of the catalytic site, and the mechanism of nucleotidyl transfer. In spite of these shared features, however, DNA polymerases display an astonishing variety in structure and function, ranging from single subunit enzymes specialized for DNA repair to complex multi-protein holoenzymes responsible for genomic DNA replication. This review uses a few well-characterized model systems to summarize our current understanding of the workings of DNA polymerases in DNA metabolism.

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