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Recent Patents on Food, Nutrition & Agriculture

Editor-in-Chief

ISSN (Print): 2212-7984
ISSN (Online): 1876-1429

Systematic Review Article

Whole Grains, Dietary Fibers and the Human Gut Microbiota: A Systematic Review of Existing Literature

Author(s): Hadith Tangestani, Hadi Emamat, Hamid Ghalandari and Sakineh Shab-Bidar*

Volume 11, Issue 3, 2020

Page: [235 - 248] Pages: 14

DOI: 10.2174/2212798411666200316152252

Price: $65

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Abstract

Background: The health benefits of dietary fibers have been proved for a long time. The importance of microbiota has been identified in human health and there is a growing interest to study the factors affecting it.

Objective: This systematic review aimed to investigate the impact of fiber and whole grains (WGs) on human gut microbiota in a patent-based review.

Methods: All related clinical trials were systematically searched on PubMed and Scopus search engines from inception up to Feb 2020. Interventional human studies reporting changes in microbiota by using any type of grains/fibers were included. The following information was extracted: date of the publication, location and design of the study, sample size, study population, demographic characteristics, the amount of dietary WGs/fiber, the duration of intervention, the types of grains or fibers, and changes in the composition of the microbiota.

Results: Of 138 studies which were verified, 35 studies with an overall population of 1080 participants, met the inclusion criteria and entered the systematic review. The results of interventional trials included in this review suggest some beneficial effects of consuming different amounts and types of WGs and fibers on the composition of intestinal microbiota. Most included studies showed that the intake of WGs and fibers increases bifidobacteria and lactobacilli and reduces the pathogenic bacteria, such as Escherichia coli and clostridia in the human gut.

Conclusion: The consumption of WGs/fibers may modify the intestinal microbiota and promote the growth of bifidobacteria and lactobacilli. Nevertheless, further research is warranted in different populations and pathological conditions.

Keywords: Whole grain, fiber, microbiota, systematic review, gut, interventional.

Graphical Abstract
[1]
Aachary AA, Gobinath D, Srinivasan K, Prapulla SG. Protective effect of xylooligosaccharides from corncob on 1,2-dimethylhydrazine induced colon cancer in rats. Bioactive Carbohydrates and Dietary Fibre 2015; 5: 146-52.
[http://dx.doi.org/10.1016/j.bcdf.2015.03.004]
[2]
Ampatzoglou A, Atwal KK, Maidens CM, et al. Increased whole grain consumption does not affect blood biochemistry, body composition, or gut microbiology in healthy, low-habitual whole grain consumers. J Nutr 2015; 145(2): 215-21.
[http://dx.doi.org/10.3945/jn.114.202176] [PMID: 25644340]
[3]
Anderson JW, Baird P, Davis RH Jr, et al. Health benefits of dietary fiber. Nutr Rev 2009; 67(4): 188-205.
[http://dx.doi.org/10.1111/j.1753-4887.2009.00189.x] [PMID: 19335713]
[4]
De Angelis M, Montemurno E, Vannini L, et al. Effect of whole-grain barley on the human fecal microbiota and metabolome. Appl Environ Microbiol 2015; 81(22): 7945-56.
[http://dx.doi.org/10.1128/AEM.02507-15] [PMID: 26386056]
[5]
Benno Y, Endo K, Miyoshi H, Okuda T, Koishi H, Mitsuoka T. Effect of rice fiber on human fecal microflora. Microbiol Immunol 1989; 33(5): 435-40.
[http://dx.doi.org/10.1111/j.1348-0421.1989.tb01992.x] [PMID: 2547140]
[6]
Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of action. Ann Nutr Metab 2012; 61(2): 160-74.
[http://dx.doi.org/10.1159/000342079] [PMID: 23037511]
[7]
Carvalho-Wells AL, Helmolz K, Nodet C, et al. Determination of the in vivo prebiotic potential of a maize-based whole grain breakfast cereal: a human feeding study. Br J Nutr 2010; 104(9): 1353-6.
[http://dx.doi.org/10.1017/S0007114510002084] [PMID: 20487589]
[8]
Cho SS, Qi L, Fahey GC Jr, Klurfeld DM. Consumption of cereal fiber, mixtures of whole grains and bran, and whole grains and risk reduction in type 2 diabetes, obesity, and cardiovascular disease. Am J Clin Nutr 2013; 98(2): 594-619.
[http://dx.doi.org/10.3945/ajcn.113.067629] [PMID: 23803885]
[9]
Christensen EG, Licht TR, Kristensen M, Bahl MI. Bifidogenic effect of whole-grain wheat during a 12-week energy-restricted dietary intervention in postmenopausal women. Eur J Clin Nutr 2013; 67(12): 1316-21.
[http://dx.doi.org/10.1038/ejcn.2013.207] [PMID: 24149441]
[10]
Connolly ML, Lovegrove JA, Tuohy KM. In vitro fermentation characteristics of whole grain wheat flakes and the effect of toasting on prebiotic potential. J Med Food 2012; 15(1): 33-43.
[http://dx.doi.org/10.1089/jmf.2011.0006] [PMID: 21877952]
[11]
Connolly ML, Tzounis X, Tuohy KM, Lovegrove JA. Hypocholesterolemic and Prebiotic Effects of a Whole-Grain Oat-Based Granola Breakfast Cereal in a Cardio-Metabolic “At Risk” Population. Front Microbiol 2016; 7: 1675.
[http://dx.doi.org/10.3389/fmicb.2016.01675] [PMID: 27872611]
[12]
Cooper DN, Kable ME, Marco ML, et al. The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota. Nutrients 2017; 9(2): 9.
[http://dx.doi.org/10.3390/nu9020173] [PMID: 28230784]
[13]
Costabile A, Deaville ER, Morales AM, Gibson GR. Prebiotic Potential of a Maize-Based Soluble Fibre and Impact of Dose on the Human Gut Microbiota. PLoS One 2016; 11(1)e0144457
[http://dx.doi.org/10.1371/journal.pone.0144457] [PMID: 26731113]
[14]
Costabile A, Klinder A, Fava F, et al. Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study. Br J Nutr 2008; 99(1): 110-20.
[http://dx.doi.org/10.1017/S0007114507793923] [PMID: 17761020]
[15]
Deguchi Y, Morishita T, Mutai M. Comparative studies on synthesis of water-soluble vitamins among human species of bifidobacteria. Agric Biol Chem 1985; 49: 13-9.
[16]
Den Besten G, Van Eunen K, Groen A K, Venema K, Reijngoud D-J, Bakker B M. The role of short-chain fatty acids in the interplay between diet, gut microbiota and host energy metabolismJournal of lipid research, jlr 2013.R036012.
[http://dx.doi.org/10.1194/jlr.R036012]
[17]
Drzikova B, Dongowski G, Gebhardt E. Dietary fibre-rich oat-based products affect serum lipids, microbiota, formation of short-chain fatty acids and steroids in rats. Br J Nutr 2005; 94(6): 1012-25.
[http://dx.doi.org/10.1079/BJN20051577] [PMID: 16351781]
[18]
Falk PG, Hooper LV, Midtvedt T, Gordon JI. Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol Mol Biol Rev 1998; 62(4): 1157-70.
[http://dx.doi.org/10.1128/MMBR.62.4.1157-1170.1998] [PMID: 9841668]
[19]
Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M, Colecchia A. Gut microbiota and metabolic syndrome. World J Gastroenterol 2014; 20(43): 16079-94.
[http://dx.doi.org/10.3748/wjg.v20.i43.16079] [PMID: 25473159]
[20]
Foerster J, Maskarinec G, Reichardt N, et al. The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. PLoS One 2014; 9(10)e109606
[http://dx.doi.org/10.1371/journal.pone.0109606] [PMID: 25299601]
[21]
Fraher MH, O’Toole PW, Quigley EM. Techniques used to characterize the gut microbiota: a guide for the clinician. Nat Rev Gastroenterol Hepatol 2012; 9(6): 312-22.
[http://dx.doi.org/10.1038/nrgastro.2012.44] [PMID: 22450307]
[22]
François IE, Lescroart O, Veraverbeke WS, et al. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial. Br J Nutr 2012; 108(12): 2229-42.
[http://dx.doi.org/10.1017/S0007114512000372] [PMID: 22370444]
[23]
François IE, Lescroart O, Veraverbeke WS, et al. Effects of wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal parameters in healthy preadolescent children. J Pediatr Gastroenterol Nutr 2014; 58(5): 647-53.
[http://dx.doi.org/10.1097/MPG.0000000000000285] [PMID: 24368315]
[24]
Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 2017; 14(8): 491-502.
[http://dx.doi.org/10.1038/nrgastro.2017.75] [PMID: 28611480]
[25]
Gråsten S, Liukkonen KH, Chrevatidis A, El-Nezami H, Poutanen K, Mykkänen H. Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutr Res 2003; 23: 1503-14.
[http://dx.doi.org/10.1016/S0271-5317(03)00164-7]
[26]
Gråsten SM, Juntunen KS, Mättö J, et al. High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota. Nutr Res 2007; 27: 454-61.
[http://dx.doi.org/10.1016/j.nutres.2007.05.010]
[27]
Guo S, Li C, Liu D, Guo Y. Inflammatory responses to a Clostridium perfringens type A strain and α-toxin in primary intestinal epithelial cells of chicken embryos. Avian Pathol 2015; 44(2): 81-91.
[http://dx.doi.org/10.1080/03079457.2015.1005573] [PMID: 25584964]
[28]
Hald S, Schioldan AG, Moore ME, et al. Effects of arabinoxylan and resistant starch on intestinal microbiota and short-chain fatty acids in subjects with metabolic syndrome: A randomised crossover study. PLoS One 2016; 11(7)e0159223
[http://dx.doi.org/10.1371/journal.pone.0159223] [PMID: 27434092]
[29]
Hara H, Haga S, Aoyama Y, Kiriyama S. Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine. J Nutr 1999; 129(5): 942-8.
[http://dx.doi.org/10.1093/jn/129.5.942] [PMID: 10222383]
[30]
Hooda S, Boler BM, Serao MC, et al. 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber. J Nutr 2012; 142(7): 1259-65.
[http://dx.doi.org/10.3945/jn.112.158766] [PMID: 22649263]
[31]
Humpf HU, Schneider C, Stevens JF. Hot Topics in 2017 - Gut Microbiota, Whole Grains and Health. Mol Nutr Food Res 2017; 61(1): 61.
[http://dx.doi.org/10.1002/mnfr.201770014] [PMID: 28044429]
[32]
Jacobs DR Jr, Marquart L, Slavin J, Kushi LH. Whole-grain intake and cancer: an expanded review and meta-analysis. Nutr Cancer 1998; 30(2): 85-96.
[http://dx.doi.org/10.1080/01635589809514647] [PMID: 9589426]
[33]
Jaskari J, Kontula P, Siitonen A, Jousimies-Somer H, Mattila-Sandholm T, Poutanen K. Oat β-glucan and xylan hydrolysates as selective substrates for Bifidobacterium and Lactobacillus strains. Appl Microbiol Biotechnol 1998; 49(2): 175-81.
[http://dx.doi.org/10.1007/s002530051155] [PMID: 9534257]
[34]
Kailasapathy K, Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol Cell Biol 2000; 78(1): 80-8.
[http://dx.doi.org/10.1046/j.1440-1711.2000.00886.x] [PMID: 10651933]
[35]
Kellow NJ, Coughlan MT, Reid CM. Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr 2014; 111(7): 1147-61.
[http://dx.doi.org/10.1017/S0007114513003607] [PMID: 24230488]
[36]
Kontula P, Jaskari J, Nollet L, et al. The colonization of a simulator of the human intestinal microbial ecosystem by a probiotic strain fed on a fermented oat bran product: effects on the gastrointestinal microbiota. Appl Microbiol Biotechnol 1998; 50(2): 246-52.
[http://dx.doi.org/10.1007/s002530051284] [PMID: 9763692]
[37]
Kushi LH, Meyer KA, Jacobs DR Jr. Cereals, legumes, and chronic disease risk reduction: evidence from epidemiologic studies. Am J Clin Nutr 1999; 70(3)(Suppl.): 451S-8S.
[http://dx.doi.org/10.1093/ajcn/70.3.451s] [PMID: 10479217]
[38]
Laitinen K, Mokkala K. Overall dietary quality relates to gut microbiota diversity and abundance. Int J Mol Sci 2019; 20(8): 1835.
[http://dx.doi.org/10.3390/ijms20081835] [PMID: 31013927]
[39]
Lappi J, Salojärvi J, Kolehmainen M, et al. Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome. J Nutr 2013; 143(5): 648-55. a
[http://dx.doi.org/10.3945/jn.112.172668] [PMID: 23514765]
[40]
Lappi J, Salojärvi J, Kolehmainen M, et al. Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome. J Nutr 2013; 143(5): 648-55. b
[http://dx.doi.org/10.3945/jn.112.172668] [PMID: 23514765]
[41]
Larsen OFA, Claassen E. The mechanistic link between health and gut microbiota diversity. Sci Rep 2018; 8(1): 2183.
[http://dx.doi.org/10.1038/s41598-018-20141-6] [PMID: 29391457]
[42]
Lin SH, Chou LM, Chien YW, Chang JS, Lin CI. Prebiotic Effects of Xylooligosaccharides on the Improvement of Microbiota Balance in Human Subjects. Gastroenterol Res Pract 2016; •••20165789232
[http://dx.doi.org/10.1155/2016/5789232] [PMID: 27651791]
[43]
Maccaferri S, Klinder A, Cacciatore S, et al. In vitro fermentation of potential prebiotic flours from natural sources: impact on the human colonic microbiota and metabolome. Mol Nutr Food Res 2012; 56(8): 1342-52.
[http://dx.doi.org/10.1002/mnfr.201200046] [PMID: 22753180]
[44]
Mano F, Ikeda K. The Effect of White Rice and White Bread as Staple Foods on Gut Microbiota and Host Metabolism 2018.
[45]
Mariat D, Firmesse O, Levenez F, et al. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 2009; 9: 123.
[http://dx.doi.org/10.1186/1471-2180-9-123] [PMID: 19508720]
[46]
Martínez I, Lattimer JM, Hubach KL, et al. Gut microbiome composition is linked to whole grain-induced immunological improvements. ISME J 2013; 7(2): 269-80.
[http://dx.doi.org/10.1038/ismej.2012.104] [PMID: 23038174]
[47]
Menne E, Guggenbuhl N, Roberfroid M. Fn-type chicory inulin hydrolysate has a prebiotic effect in humans. J Nutr 2000; 130(5): 1197-9.
[http://dx.doi.org/10.1093/jn/130.5.1197] [PMID: 10801918]
[48]
Middelbos IS, Vester Boler BM, Qu A, White BA, Swanson KS, Fahey GC Jr. Phylogenetic characterization of fecal microbial communities of dogs fed diets with or without supplemental dietary fiber using 454 pyrosequencing. PLoS One 2010; 5(3)e9768
[http://dx.doi.org/10.1371/journal.pone.0009768] [PMID: 20339542]
[49]
Mirsepasi-Lauridsen HC, Vallance BA, Krogfelt KA, Petersen AM. Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease. Clin Microbiol Rev 2019; 32(2): e00060-18.
[http://dx.doi.org/10.1128/CMR.00060-18] [PMID: 30700431]
[50]
Mitsou EK, Panopoulou N, Turunen K, Spiliotis V, Kyriacou A. Prebiotic potential of barley derived β-glucan at low intake levels: A randomised, double-blinded, placebo-controlled clinical study. Food Res Int 2010; 43: 1086-92.
[http://dx.doi.org/10.1016/j.foodres.2010.01.020]
[51]
Mitsuoka T, Hidaka H, Eida T. Effect of fructo‐oligosaccharides on intestinal microflora Food / Nahrung 1987; 31: 427-36.
[http://dx.doi.org/10.1002/food.19870310528]
[52]
Molist F, Manzanilla EG, Pérez JF, Nyachoti CM. Coarse, but not finely ground, dietary fibre increases intestinal Firmicutes:Bacteroidetes ratio and reduces diarrhoea induced by experimental infection in piglets. Br J Nutr 2012; 108(1): 9-15.
[http://dx.doi.org/10.1017/S0007114511005216] [PMID: 22018207]
[53]
Montonen J, Knekt P, Järvinen R, Aromaa A, Reunanen A. Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr 2003; 77(3): 622-9.
[http://dx.doi.org/10.1093/ajcn/77.3.622] [PMID: 12600852]
[54]
Nakamura YK, Omaye ST. Metabolic diseases and pro- and prebiotics: Mechanistic insights. Nutr Metab (Lond) 2012; 9(1): 60.
[http://dx.doi.org/10.1186/1743-7075-9-60] [PMID: 22713169]
[55]
Picot J, Hartwell D, Harris P, Mendes D, Clegg A, Takeda A. 2012 The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. The American journal of clinical nutrition, 2012; 77: 622-9.
[56]
Roager H M, Vogt J K, Kristensen M. Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial 2019; 68: 83-93.
[57]
Ross AB, Bruce SJ, Blondel-Lubrano A, et al. A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. Br J Nutr 2011; 105(10): 1492-502.
[http://dx.doi.org/10.1017/S0007114510005209] [PMID: 21272402]
[58]
Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994; 344(8929): 1046-9.
[http://dx.doi.org/10.1016/S0140-6736(94)91708-6] [PMID: 7934445]
[59]
Sawicki CM, Livingston KA, Obin M, Roberts SB, Chung M, McKeown NM. Dietary fiber and the human gut microbiota: Application of evidence mapping methodology. Nutrients 2017; 9(2): 9.
[http://dx.doi.org/10.3390/nu9020125] [PMID: 28208609]
[60]
Scholz-Ahrens KE, Schaafsma G, van den Heuvel EG, Schrezenmeir J. Effects of prebiotics on mineral metabolism. Am J Clin Nutr 2001; 73(2)(Suppl.): 459S-64S.
[http://dx.doi.org/10.1093/ajcn/73.2.459s] [PMID: 11157358]
[61]
Schutte S, Esser D, Hoevenaars FPM, et al. A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects. Am J Clin Nutr 2018; 108(6): 1264-74.
[http://dx.doi.org/10.1093/ajcn/nqy204] [PMID: 30541093]
[62]
Senghor B, Sokhna C, Ruimy R, Lagier J-C. Gut microbiota diversity according to dietary habits and geographical provenance. Human Microbiome Journal 2018; 7-8: 1-9.
[http://dx.doi.org/10.1016/j.humic.2018.01.001]
[63]
Sheflin AM, Borresen EC, Kirkwood JS, et al. Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors. Mol Nutr Food Res 2017; 61(1): 61.
[http://dx.doi.org/10.1002/mnfr.201500905] [PMID: 27461523]
[64]
Slavin J. Why whole grains are protective: biological mechanisms. Proc Nutr Soc 2003; 62(1): 129-34.
[http://dx.doi.org/10.1079/PNS2002221] [PMID: 12740067]
[65]
Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients 2013; 5(4): 1417-35.
[http://dx.doi.org/10.3390/nu5041417] [PMID: 23609775]
[66]
Snart J, Bibiloni R, Grayson T, et al. Supplementation of the diet with high-viscosity beta-glucan results in enrichment for lactobacilli in the rat cecum. Appl Environ Microbiol 2006; 72(3): 1925-31.
[http://dx.doi.org/10.1128/AEM.72.3.1925-1931.2006] [PMID: 16517639]
[67]
Stecher B, Chaffron S, Käppeli R, et al. Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathog 2010; 6(1)e1000711
[http://dx.doi.org/10.1371/journal.ppat.1000711] [PMID: 20062525]
[68]
Tannock GW, Munro K, Bibiloni R, et al. Impact of consumption of oligosaccharide-containing biscuits on the fecal microbiota of humans. Appl Environ Microbiol 2004; 70(4): 2129-36.
[http://dx.doi.org/10.1128/AEM.70.4.2129-2136.2004] [PMID: 15066805]
[69]
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J 2017; 474(11): 1823-36.
[http://dx.doi.org/10.1042/BCJ20160510] [PMID: 28512250]
[70]
Tremaroli V, Bäckhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489(7415): 242-9.
[http://dx.doi.org/10.1038/nature11552] [PMID: 22972297]
[71]
Tuohy KM, Kolida S, Lustenberger AM, Gibson GR. The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides--a human volunteer study. Br J Nutr 2001; 86(3): 341-8.
[http://dx.doi.org/10.1079/BJN2001394] [PMID: 11570986]
[72]
Turunen K, Tsouvelakidou E, Nomikos T, et al. Impact of beta-glucan on the faecal microbiota of polypectomized patients: a pilot study. Anaerobe 2011; 17(6): 403-6.
[http://dx.doi.org/10.1016/j.anaerobe.2011.03.025] [PMID: 21515398]
[73]
Velikonja A, Lipoglavšek L, Zorec M, Orel R, Avguštin G. Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development. Anaerobe 2019; 55: 67-77.
[http://dx.doi.org/10.1016/j.anaerobe.2018.11.002] [PMID: 30396006]
[74]
Walton GE, Lu C, Trogh I, Arnaut F, Gibson GR. A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers. Nutr J 2012; 11: 36.
[http://dx.doi.org/10.1186/1475-2891-11-36] [PMID: 22657950]
[75]
Wang Y, Ames NP, Tun HM, Tosh SM, Jones PJ, Khafipour E. High Molecular Weight Barley β-Glucan Alters Gut Microbiota Toward Reduced Cardiovascular Disease Risk. Front Microbiol 2016; 7: 129.
[http://dx.doi.org/10.3389/fmicb.2016.00129] [PMID: 26904005]
[76]
Whisner CM, Martin BR, Nakatsu CH, et al. Soluble Corn Fiber Increases Calcium Absorption Associated with Shifts in the Gut Microbiome: A Randomized Dose-Response Trial in Free-Living Pubertal Females. J Nutr 2016; 146(7): 1298-306.
[http://dx.doi.org/10.3945/jn.115.227256] [PMID: 27281813]
[77]
Whisner CM, Martin BR, Schoterman MHC, et al. Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial. Br J Nutr 2013; 110(7): 1292-303.
[http://dx.doi.org/10.1017/S000711451300055X] [PMID: 23507173]
[78]
Windey K, De Preter V, Huys G, et al. Wheat bran extract alters colonic fermentation and microbial composition, but does not affect faecal water toxicity: a randomised controlled trial in healthy subjects. Br J Nutr 2015; 113(2): 225-38.
[http://dx.doi.org/10.1017/S0007114514003523] [PMID: 25498469]
[79]
Wu H, Flint AJ, Qi Q, et al. Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women. JAMA Intern Med 2015; 175(3): 373-84.
[http://dx.doi.org/10.1001/jamainternmed.2014.6283] [PMID: 25559238]
[80]
Yoo JY, Kim SS. Probiotics and Prebiotics: Present Status and Future Perspectives on Metabolic Disorders. Nutrients 2016; 8(3): 173-3.
[http://dx.doi.org/10.3390/nu8030173] [PMID: 26999199]

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