Login Register Cart 0
Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review

Author(s): Bellamkonda Bosebabu, Sri Pragnya Cheruku, Mallikarjuna Rao Chamallamudi , Madhavan Nampoothiri, Rekha R. Shenoy, Krishnadas Nandakumar, Vipan K. Parihar and Nitesh Kumar*

Volume 20, Issue 11, 2020

Page: [988 - 1000] Pages: 13

DOI: 10.2174/1389557520666200313120419

Price: $65

Abstract

Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non‐toxic chemical that mediates anti‐inflammatory effects by down‐regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis in cancer cells via mitochondrial and receptor‐mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.

Keywords: Sesamol, pleiotropic sesame seed, antioxidant, anti-inflammatory, pharmacological activities, anti-microbial, cancer cells, in vitro, in vivo.

« Previous Next »
Graphical Abstract

[1]
Miraj, S.; Kiani, S. Bioactivity of Sesamum Indicum: A review study. Der Pharm. Lett., 2016, 8(6), 328-334.
[2]
Pathak, N.; Rai, A.K.; Kumari, R.; Bhat, K.V. Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability. Pharmacogn. Rev., 2014, 8(16), 147-155.
[http://dx.doi.org/10.4103/0973-7847.134249] [PMID: 25125886]
[3]
Lee, J.; Lee, Y.; Choe, E. Effects of Sesamol, Sesamin, and Sesamolin extracted from roasted sesame oil on the thermal oxidation of Methyl Linoleate. Lebensm. Wiss. Technol., 2008, 41(10), 1871-1875.
[http://dx.doi.org/10.1016/j.lwt.2007.11.019]
[4]
Belitz, H-D.; Grosch, W.; Schieberle, P. Edible fats and oils. Food Chem., 2008, 640-669.
[http://dx.doi.org/10.1007/978-3-540-69934-7_15]
[5]
Katsuzaki, H.; Osawa, T.; Kawakishi, S. Chemistry and antioxidative activity of lignan glucosides in sesame seed. 1994.
[http://dx.doi.org/10.1021/bk-1994-0547.ch028]
[6]
Geetha, T.; Singh, N.; Deol, P.K.; Kaur, I.P. Biopharmaceutical profiling of sesamol: Physiochemical characterization, gastrointestinal permeability and pharmacokinetic evaluation. RSC Advances, 2015, 5(6), 4083-4091.
[http://dx.doi.org/10.1039/C4RA10926K]
[7]
Yashaswini, P.S.; Rao, A.G.A.A.; Singh, S.A. Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity. RSC Adv., 2017, 5(6), 4083-4091.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.06.048]
[8]
Shimizu, S.; Fujii, G.; Takahashi, M.; Nakanishi, R.; Komiya, M.; Shimura, M.; Noma, N.; Onuma, W.; Terasaki, M.; Yano, T.; Mutoh, M. Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice. J. Clin. Biochem. Nutr., 2014, 54(2), 95-101.
[http://dx.doi.org/10.3164/jcbn.13-91] [PMID: 24688218]
[9]
Khan, S.; Choudhary, S.; Kumar, A.; Tripathi, A.M.; Alok, A.; Adhikari, J.S.; Rizvi, M.A.; Chaudhury, N.K. Evaluation of sesamol-induced histopathological, biochemical, haematological and genomic alteration after acute oral toxicity in female C57BL/6 mice. Toxicol. Rep., 2016, 3, 880-894.
[http://dx.doi.org/10.1016/j.toxrep.2016.03.005] [PMID: 28959616]
[10]
Ambrose, A.M.; Cox, A.J., Jr; DeEds, F. Antioxidant Toxicity, Toxicological Studies on Sesamol. J. Agric. Food Chem., 1958, 6(8), 600-604.
[http://dx.doi.org/10.1021/jf60090a008]
[11]
Yeo, J.; Park, J.; Lee, J. Evaluation of antioxidant capacity of sesamol and free radical scavengers at different heating temperatures. Eur. J. Lipid Sci. Technol., 2011, 113(7), 910-915.
[http://dx.doi.org/10.1002/ejlt.201000553]
[12]
Hemalatha, G.; Pugalendi, K.V.; Saravanan, R. Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats. Mol. Cell. Biochem., 2013, 379(1-2), 255-265.
[http://dx.doi.org/10.1007/s11010-013-1647-1] [PMID: 23576423]
[13]
Kumar, N.; Mudgal, J.; Parihar, V.K.; Nayak, P.G.; Kutty, N.G.; Rao, C.M. Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia. Lipids, 2013, 48(6), 633-638.
[http://dx.doi.org/10.1007/s11745-013-3778-2] [PMID: 23504268]
[14]
Kapadia, G.J.; Azuine, M.A.; Tokuda, H.; Takasaki, M.; Mukainaka, T.; Konoshima, T.; Nishino, H. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol. Res., 2002, 45(6), 499-505.
[http://dx.doi.org/10.1006/phrs.2002.0992] [PMID: 12162952]
[15]
Ren, B.; Yuan, T.; Diao, Z.; Zhang, C.; Liu, Z.; Liu, X. Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway. Food Funct., 2018, 9(11), 5912-5924.
[http://dx.doi.org/10.1039/C8FO01436A] [PMID: 30375618]
[16]
Shah, A.; Lobo, R.; Krishnadas, N.; Surubhotla, R. Sesamol and health - A comprehensive review. Indian J. Pharm. Educ. Res., 2019, 53(2), S28-S42.
[http://dx.doi.org/10.5530/ijper.53.2s.46]
[17]
Poljšak, B.; Fink, R. The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pollution. Oxid. Med. Cell. Longev., 2014, 2014, 671539
[http://dx.doi.org/10.1155/2014/671539] [PMID: 25140198]
[18]
Parihar, V.K.; Prabhakar, K.R.; Veerapur, V.P.; Kumar, M.S.; Reddy, Y.R.; Joshi, R.; Unnikrishnan, M.K.; Rao, C.M. Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. Mutat. Res., 2006, 611(1-2), 9-16.
[http://dx.doi.org/10.1016/j.mrgentox.2006.06.037] [PMID: 17045515]
[19]
Hsu, D.Z.; Chien, S.P.; Chen, K.T.; Liu, M.Y. The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice. Shock, 2007, 28(5), 596-601.
[http://dx.doi.org/10.1097/shk.0b013e31804d4474] [PMID: 17589387]
[20]
Chen, X.; Ahn, D.U. Antioxidant activities of six natural phenolics against lipid oxidation induced by Fe2+ or ultraviolet light. J. Am. Oil Chem. Soc., 1998, 75(12), 1717-1721.
[http://dx.doi.org/10.1007/s11746-998-0322-2]
[21]
Joshi, R.; Kumar, M.S.; Satyamoorthy, K.; Unnikrisnan, M.K.; Mukherjee, T. Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies. J. Agric. Food Chem., 2005, 53(7), 2696-2703.
[http://dx.doi.org/10.1021/jf0489769] [PMID: 15796613]
[22]
Chu, P.Y.; Hsu, D.Z.; Hsu, P.Y.; Liu, M.Y. Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation. Innate Immun., 2010, 16(5), 333-339.
[http://dx.doi.org/10.1177/1753425909351880] [PMID: 19939906]
[23]
Wu, X.L.; Liou, C.J.; Li, Z.Y.; Lai, X.Y.; Fang, L.W.; Huang, W.C. Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages. Inflamm. Res., 2015, 64(8), 577-588.
[http://dx.doi.org/10.1007/s00011-015-0836-7] [PMID: 26059394]
[24]
Jacklin, A.; Ratledge, C.; Welham, K.; Bilko, D.; Newton, C.J. The sesame seed oil constituent, sesamol, induces growth arrest and apoptosis of cancer and cardiovascular cells. Ann. N. Y. Acad. Sci., 2003, 1010, 374-380.
[http://dx.doi.org/10.1196/annals.1299.068] [PMID: 15033755]
[25]
Geetha, T.; Kapila, M.; Prakash, O.; Deol, P.K.; Kakkar, V.; Kaur, I.P. Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer. J. Drug Target., 2015, 23(2), 159-169.
[http://dx.doi.org/10.3109/1061186X.2014.965717] [PMID: 25268273]
[26]
Khamphio, M.; Barusrux, S.; Weerapreeyakul, N. Sesamol induces mitochondrial apoptosis pathway in HCT116 human colon cancer cells via pro-oxidant effect. Life Sci., 2016, 158, 46-56.
[http://dx.doi.org/10.1016/j.lfs.2016.06.017] [PMID: 27328416]
[27]
Kumar, C.M.; Sathisha, U.V.; Dharmesh, S.; Rao, A.G.A.; Singh, S.A. Interaction of sesamol (3,4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis. Biochimie, 2011, 93(3), 562-569.
[http://dx.doi.org/10.1016/j.biochi.2010.11.014] [PMID: 21144881]
[28]
Nayak, P.G.; Paul, P.; Bansal, P.; Kutty, N.G.; Pai, K.S.R. Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts. J. Pharm. Pharmacol., 2013, 65(7), 1083-1093.
[http://dx.doi.org/10.1111/jphp.12073] [PMID: 23738736]
[29]
Liu, Z.; Xiang, Q.; Du, L.; Song, G.; Wang, Y.; Liu, X. The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells. Food Chem., 2013, 141(1), 289-296.
[http://dx.doi.org/10.1016/j.foodchem.2013.02.105] [PMID: 23768360]
[30]
Prasad, N.; Shanmugham, M. Radiosensitizing effect of sesamol on human cervical carcinoma cells. Int. J. Nutr. Pharmacol. Neurol. Dis., 2012, 2(3), 210.
[http://dx.doi.org/10.4103/2231-0738.99472]
[31]
Liu, Z.; Ren, B.; Wang, Y.; Zou, C.; Qiao, Q.; Diao, Z.; Mi, Y.; Zhu, D.; Liu, X. sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy. Sci. Rep., 2017, 7, 45728.
[http://dx.doi.org/10.1038/srep45728] [PMID: 28374807]
[32]
Bhardwaj, R.; Sanyal, S.N.; Vaiphei, K.; Kakkar, V.; Deol, P.K.; Kaur, I.P.; Kaur, T. Sesamol induces apoptosis by altering expression of Bcl-2 and bax proteins and modifies skin tumor development in Balb/c mice. Anticancer. Agents Med. Chem., 2017, 17(5), 726-733.
[http://dx.doi.org/10.2174/1871520616666160819103249] [PMID: 27539478]
[33]
Pianjing, P.; Thiantanawat, A.; Rangkadilok, N.; Watcharasit, P.; Mahidol, C.; Satayavivad, J. Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells. J. Agric. Food Chem., 2011, 59(1), 212-221.
[http://dx.doi.org/10.1021/jf102006w] [PMID: 21141889]
[34]
Gao, X.J.; Xie, G.N.; Liu, L.; Fu, Z.J.; Zhang, Z.W.; Teng, L.Z. Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury. Exp. Ther. Med., 2017, 14(1), 841-847.
[http://dx.doi.org/10.3892/etm.2017.4550] [PMID: 28673008]
[35]
Hassanzadeh, P.; Arbabi, E.; Rostami, F. The ameliorative effects of sesamol against seizures, cognitive impairment and oxidative stress in the experimental model of epilepsy. Iran. J. Basic Med. Sci., 2014, 17(2), 100-107.
[http://dx.doi.org/10.22038/ijbms.2014.2241] [PMID: 24711892]
[36]
Narasimhan, R.; Vaithiyanathan, M.; Janardanam, V. Neuroprotective effect of sesamol in glioma induced in rats. Biomed. Int., 2011, 2(1), 22-27.
[37]
Chopra, K.; Tiwari, V.; Arora, V.; Kuhad, A. Sesamol suppresses neuro-inflammatory cascade in experimental model of diabetic neuropathy. J. Pain, 2010, 11(10), 950-957.
[http://dx.doi.org/10.1016/j.jpain.2010.01.006] [PMID: 20418182]
[38]
Kumar, P.; Kalonia, H.; Kumar, A. Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats. Basic Clin. Pharmacol. Toxicol., 2010, 107(1), 577-582.
[http://dx.doi.org/10.1111/j.1742-7843.2010.00537.x] [PMID: 20102363]
[39]
Kumar, B.; Kuhad, A.; Chopra, K. Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences. Psychopharmacology (Berl.), 2011, 214(4), 819-828.
[http://dx.doi.org/10.1007/s00213-010-2094-2] [PMID: 21103863]
[40]
Liu, Z.; Liu, X.; Luo, S.; Chu, C.; Wu, D.; Liu, R.; Wang, L.; Wang, J.; Liu, X. Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits. J. Funct. Foods, 2018, 42, 237-247.
[http://dx.doi.org/10.1016/j.jff.2018.01.005]
[41]
Kumar, A.; Kaur, G.; Kalonia, H.; Rinwa, P. Evaluation of sesamol and buspirone in stress induced anxiety in mice. Indian J. Pharmacol., 2013, 45(1), 49-53.
[http://dx.doi.org/10.4103/0253-7613.106435] [PMID: 23543858]
[42]
Shaker, S.C.; Ashok, J.; Kumar, B.B.; Priram, M.P. 2.a.001 Effect of sesamol pretreatment against lipopolysaccharide-induced depressive and anxiety-like behaviour in swiss albino mice. Eur. Neuropsychopharmacol., 2015, 25, S374-S375.
[http://dx.doi.org/10.1016/S0924-977X(15)30485-5]
[43]
Sonia Angeline, M.; Sarkar, A.; Anand, K.; Ambasta, R.K.; Kumar, P. Sesamol and naringenin reverse the effect of rotenone-induced PD rat model. Neuroscience, 2013, 254, 379-394.
[http://dx.doi.org/10.1016/j.neuroscience.2013.09.029] [PMID: 24070629]
[44]
Mahdy, H.M.; Tadros, M.G.; Mohamed, M.R.; Karim, A.M.; Khalifa, A.E. The effect of Ginkgo biloba extract on 3-nitropropionic acid-induced neurotoxicity in rats. Neurochem. Int., 2011, 59(6), 770-778.
[http://dx.doi.org/10.1016/j.neuint.2011.07.012] [PMID: 21827809]
[45]
John, J.; Nampoothiri, M.; Kumar, N.; Mudgal, J.; Nampurath, G.K.; Chamallamudi, M.R. Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats. Pharmacogn. Mag., 2015, 11(42), 327-336.
[http://dx.doi.org/10.4103/0973-1296.153086] [PMID: 25829772]
[46]
Sachdeva, A.K.; Misra, S.; Pal Kaur, I.; Chopra, K. Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: behavioral and biochemical evidence. Eur. J. Pharmacol., 2015, 747, 132-140.
[http://dx.doi.org/10.1016/j.ejphar.2014.11.014] [PMID: 25449035]
[47]
Soliman, K.F.A.; Mazzio, E.A. In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proc. Soc. Exp. Biol. Med., 1998, 218(4), 390-397.
[http://dx.doi.org/10.3181/00379727-218-44309] [PMID: 9714085]
[48]
Kimura, T.; Ishiguro, K.; Hisanaga, S. Physiological and pathological phosphorylation of tau by Cdk5. Front. Mol. Neurosci., 2014, 7(JULY), 65.
[http://dx.doi.org/10.3389/fnmol.2014.00065] [PMID: 25076872]
[49]
Bartzokis, G. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease. Neurobiol. Aging, 2004, 25(1), 5-18.
[http://dx.doi.org/10.1016/j.neurobiolaging.2003.03.001] [PMID: 14675724]
[50]
Misra, S.; Tiwari, V.; Kuhad, A.; Chopra, K. Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats. Eur. J. Pharmacol., 2011, 659(2-3), 177-186.
[http://dx.doi.org/10.1016/j.ejphar.2011.03.026] [PMID: 21463622]
[51]
Moodie, F.M.; Marwick, J.A.; Anderson, C.S.; Szulakowski, P.; Biswas, S.K.; Bauter, M.R.; Kilty, I.; Rahman, I. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J., 2004, 18(15), 1897-1899.
[http://dx.doi.org/10.1096/fj.04-1506fje] [PMID: 15456740]
[52]
Shi, D.; Xiao, X.; Wang, J.; Liu, L.; Chen, W.; Fu, L.; Xie, F.; Huang, W.; Deng, W. Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling. J. Pineal Res., 2012, 53(2), 154-165.
[http://dx.doi.org/10.1111/j.1600-079X.2012.00982.x] [PMID: 22348531]
[53]
Liu, Q.; Chen, Y.; Shen, C.; Xiao, Y.; Wang, Y.; Liu, Z.; Liu, X. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB J., 2017, 31(4), 1494-1507.
[http://dx.doi.org/10.1096/fj.201601071R] [PMID: 28003341]
[54]
Fonseca, A.C.R.G.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F. Cholesterol and statins in Alzheimer’s disease: current controversies. Exp. Neurol., 2010, 223(2), 282-293.
[http://dx.doi.org/10.1016/j.expneurol.2009.09.013] [PMID: 19782682]
[55]
Nampoothiri, M.; Kumar, N.; Venkata Ramalingayya, G.; Gopalan Kutty, N.; Krishnadas, N.; Mallikarjuna Rao, C. Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats. Neuroreport, 2017, 28(9), 540-544.
[http://dx.doi.org/10.1097/WNR.0000000000000799] [PMID: 28498150]
[56]
Nampoothiri, M.; Ramalingayya, G.V.; Kutty, N.G.; Krishnadas, N.; Rao, C.M. Insulin combined with glucose improves spatial learning and memory in aluminum chloride-induced dementia in rats. J. Environ. Pathol. Toxicol. Oncol., 2017, 36(2), 159-169.
[http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2017020185] [PMID: 29199596]
[57]
Liu, Z.; Sun, Y.; Qiao, Q.; Zhao, T.; Zhang, W.; Ren, B.; Liu, Q.; Liu, X. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system. Food Funct., 2017, 8(2), 710-719.
[http://dx.doi.org/10.1039/C6FO01562J] [PMID: 28102395]
[58]
Richards, D. Prevalence and clinical course of depression: a review. Clin. Psychol. Rev., 2011, 31(7), 1117-1125.
[http://dx.doi.org/10.1016/j.cpr.2011.07.004] [PMID: 21820991]
[59]
Craske, M.G.; Stein, M.B.; Eley, T.C.; Milad, M.R.; Holmes, A.; Rapee, R.M.; Wittchen, H.U. Anxiety disorders. Nat. Rev. Dis. Primers, 2017, 3, 17024.
[http://dx.doi.org/10.1038/nrdp.2017.24] [PMID: 28470168]
[60]
Shaker, S.C.; Mangala, L.; Reddy, K.E. Evaluation of anxiolytic activity of sesamol in swiss albino mice. J. PharmTech. Res. Am. J. PharmTech Res., 2013, 3(2), 4-6.
[http://dx.doi.org/10.4172/2161-1459.1000146]
[61]
Grisar, T.; Bottin, P.; de Borchgrave d’Alténa, V.; Brichart, C.; Delcourt, C.; Dubru, J.M.; Foulon, M.; Ghariani, S.; Hotermans, C.; Legros, B.; Ossemann, M.; Sadzot, B.; Tugendhaft, P.; Van Bogaert, P.; van Rijckevorsel, K.; Verheulpen, D. Prophylaxis of the epilepsies: should anti-epileptic drugs be used for preventing seizures after acute brain injury? Acta Neurol. Belg., 2005, 105(1), 5-13.
[PMID: 15861989]
[62]
Vennila, L.; Pugalendi, K.V. Protective effect of sesamol against myocardial infarction caused by isoproterenol in Wistar rats. Redox Rep., 2010, 15(1), 36-42.
[http://dx.doi.org/10.1179/174329210X12650506623168] [PMID: 20196927]
[63]
Verma, N. Introduction to hyperlipidemia and its treatment: A review. Int. J. Curr. Pharm. Res., 2016, 9(1), 6.
[http://dx.doi.org/10.22159/ijcpr.2017v9i1.16616]
[64]
Kumar, A.; Choudhary, S.; Adhikari, J.S.; Chaudhury, N.K. Sesamol ameliorates radiation induced DNA damage in hematopoietic system of whole body γ-irradiated mice. Environ. Mol. Mutagen., 2018, 59(1), 79-90.
[http://dx.doi.org/10.1002/em.22118] [PMID: 28766757]
[65]
Prasad, N.R.; Menon, V.P.; Vasudev, V.; Pugalendi, K.V. Radioprotective effect of sesamol on γ-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology, 2005, 209(3), 225-235.
[http://dx.doi.org/10.1016/j.tox.2004.12.009] [PMID: 15795059]
[66]
Kanimozhi, P.; Prasad, N.R. Antioxidant potential of sesamol and its role on radiation-induced DNA damage in whole-body irradiated Swiss albino mice. Environ. Toxicol. Pharmacol., 2009, 28(2), 192-197.
[http://dx.doi.org/10.1016/j.etap.2009.04.003] [PMID: 21784002]
[67]
Elseweidy, M.M. Role of Natural Antioxidants in Gastritis. Gastritis Gastric Cancer - New Insights Gastroprotection, Diagnosis Treat., 2011, No. i
[http://dx.doi.org/10.5772/24336]
[68]
Hsu, D.Z.; Chu, P.Y.; Chandrasekaran, V.R.M.; Liu, M.Y. Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats. J. Funct. Foods, 2009, 1(4), 349-355.
[http://dx.doi.org/10.1016/j.jff.2009.07.003]
[69]
Hsu, D.Z.; Chen, Y.W.; Chu, P.Y.; Periasamy, S.; Liu, M.Y. Protective effect of 3,4-methylenedioxyphenol (sesamol) on stress-related mucosal disease in rats. BioMed Res. Int., 2013, 2013, 481827
[http://dx.doi.org/10.1155/2013/481827] [PMID: 23984371]
[70]
Chang, C.C.; Lu, W.J.; Chiang, C.W.; Jayakumar, T.; Ong, E.T.; Hsiao, G.; Fong, T.H.; Chou, D.S.; Sheu, J.R. Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase. J. Nutr. Biochem., 2010, 21(12), 1214-1221.
[http://dx.doi.org/10.1016/j.jnutbio.2009.10.009] [PMID: 20015631]
[71]
Chang, C.C.; Lu, W.J.; Ong, E.T.; Chiang, C.W.; Lin, S.C.; Huang, S.Y.; Sheu, J.R. A novel role of sesamol in inhibiting nf-b-mediated signaling in platelet activation. J. Biomed. Sci., 2011, 18(1), 1-10.
[http://dx.doi.org/10.1186/1423-0127-18-93] [PMID: 21699681]
[72]
Chen, P.R.; Lee, C.C.; Chang, H.; Tsai, C.E. Sesamol regulates plasminogen activator gene expression in cultured endothelial cells: a potential effect on the fibrinolytic system. J. Nutr. Biochem., 2005, 16(1), 59-64.
[http://dx.doi.org/10.1016/j.jnutbio.2004.07.008] [PMID: 15629242]
[73]
Thushara, R.M.; Hemshekhar, M.; Sunitha, K.; Kumar, M.S.; Naveen, S.; Kemparaju, K.; Girish, K.S. Sesamol induces apoptosis in human platelets via reactive oxygen species-mediated mitochondrial damage. Biochimie, 2013, 95(11), 2060-2068.
[http://dx.doi.org/10.1016/j.biochi.2013.07.032] [PMID: 23933095]
[74]
Thushara, R.M.; Hemshekhar, M.; Paul, M.; Shanmuga Sundaram, M.; Shankar, R.L.; Kemparaju, K.; Girish, K.S. Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets. J. Thromb. Thrombolysis, 2014, 38(3), 321-330.
[http://dx.doi.org/10.1007/s11239-014-1056-7] [PMID: 24705676]
[75]
Xu, F.; Zhang, C.; Graves, D.T. Abnormal cell responses and role of TNF-α in impaired diabetic wound healing. BioMed Res. Int., 2013, 2013, 754802
[http://dx.doi.org/10.1155/2013/754802] [PMID: 23484152]
[76]
Kasiewicz, L.N.; Whitehead, K.A. Recent advances in biomaterials for the treatment of diabetic foot ulcers. Biomater. Sci., 2017, 5(10), 1962-1975.
[http://dx.doi.org/10.1039/C7BM00264E] [PMID: 28829074]
[77]
Larouche, J.; Sheoran, S.; Maruyama, K.; Martino, M.M. Immune regulation of skin wound healing: Mechanisms and novel therapeutic targets. Adv. Wound Care (New Rochelle), 2018, 7(7), 209-231.
[http://dx.doi.org/10.1089/wound.2017.0761] [PMID: 29984112]
[78]
Gökşen, S.; Balabanlı, B.; Coşkun-Cevher, Ş. Application of platelet derived growth factor-BB and diabetic wound healing: the relationship with oxidative events. Free Radic. Res., 2017, 51(5), 498-505.
[http://dx.doi.org/10.1080/10715762.2017.1327715] [PMID: 28480814]
[79]
Rao, M.C.; Sudheendra, A.T.; Nayak, P.G.; Paul, P.; Kutty, G.N.; Shenoy, R.R. Effect of dehydrozingerone, a half analog of curcumin on dexamethasone-delayed wound healing in albino rats. Mol. Cell. Biochem., 2011, 355(1-2), 249-256.
[http://dx.doi.org/10.1007/s11010-011-0861-y] [PMID: 21567208]
[80]
Brem, H.; Tomic-Canic, M. Cellular and molecular basis of wound healing in diabetes. J. Clin. Invest., 2007, 117(5), 1219-1222.
[http://dx.doi.org/10.1172/JCI32169] [PMID: 17476353]
[81]
Ellis, S.; Lin, E.J.; Tartar, D. Immunology of wound healing. Curr. Dermatol. Rep., 2018, 7(4), 350-358.
[http://dx.doi.org/10.1007/s13671-018-0234-9] [PMID: 30524911]
[82]
Shenoy, R.R.; Sudheendra, A.T.; Nayak, P.G.; Paul, P.; Kutty, N.G.; Rao, C.M. Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats. J. Ethnopharmacol., 2011, 133(2), 608-612.
[http://dx.doi.org/10.1016/j.jep.2010.10.045] [PMID: 21035533]
[83]
Smit, N.; Vicanova, J.; Pavel, S. The hunt for natural skin whitening agents. Int. J. Mol. Sci., 2009, 10(12), 5326-5349.
[http://dx.doi.org/10.3390/ijms10125326] [PMID: 20054473]
[84]
Uchida, R.; Ishikawa, S.; Tomoda, H. Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol. Acta Pharm. Sin. B, 2014, 4(2), 141-145.
[http://dx.doi.org/10.1016/j.apsb.2013.12.008] [PMID: 26579376]
[85]
Srisayam, M.; Weerapreeyakul, N.; Barusrux, S.; Kanokmedhakul, Antioxidant, antimelanogenic, and skin-protective effect of sesamol. J. Cosmet. Sci., 2014, 65, 69-79.
[86]
Rao, A.S.; Nayanatara, A.K.; Anand, K.; Poojary, D.; Pai, S.R. Effect of antibacterial and antifungal activities of sesamum indicum. World J. Pharm. Res., 2013, 2(5), 1676-1680.
[87]
Mahendra Kumar, C.; Singh, S.A. Bioactive lignans from sesame (Sesamum indicum L.): evaluation of their antioxidant and antibacterial effects for food applications. J. Food Sci. Technol., 2015, 52(5), 2934-2941.
[http://dx.doi.org/10.1007/s13197-014-1334-6] [PMID: 25892793]
[88]
Ansari, M.A.; Fatima, Z.; Hameed, S. Sesamol: a natural phenolic compound with promising anticandidal potential. J. Pathogens, 2014, 2014, 895193
[http://dx.doi.org/10.1155/2014/895193] [PMID: 25574401]
[89]
Hans, S.; Sharma, S.; Hameed, S.; Fatima, Z. Sesamol exhibits potent antimycobacterial activity: Underlying mechanisms and impact on virulence traits. J. Glob. Antimicrob. Resist., 2017, 10, 228-237.
[http://dx.doi.org/10.1016/j.jgar.2017.06.007] [PMID: 28735047]
[90]
Periasamy, S.; Mo, F.E.; Chen, S.Y.; Chang, C.C.; Liu, M.Y. Sesamol attenuates isoproterenol-induced acute myocardial infarction via inhibition of matrix metalloproteinase-2 and -9 expression in rats. Cell. Physiol. Biochem., 2011, 27(3-4), 273-280.
[http://dx.doi.org/10.1159/000327953] [PMID: 21471716]
[91]
Lu, Y.C.; Jayakumar, T.; Duann, Y.F.; Chou, Y.C.; Hsieh, C.Y.; Yu, S.Y.; Sheu, J.R.; Hsiao, G. Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. J. Agric. Food Chem., 2011, 59(9), 4969-4978.
[http://dx.doi.org/10.1021/jf1046738] [PMID: 21428299]
[92]
Bhaargavi, V.; Jyotsna, G.S.L.; Tripurana, R. a review on hepatoprotective activity. Int. J. Pharm. Sci. Res., 2014, 5(3), 690-702.
[http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).690-02]
[93]
Chandrasekaran, V.R.M.; Hsu, D.Z.; Liu, M.Y. The protective effect of sesamol against mitochondrial oxidative stress and hepatic injury in acetaminophen-overdosed rats. Shock, 2009, 32(1), 89-93.
[http://dx.doi.org/10.1097/SHK.0b013e31818ede6f] [PMID: 18948843]
[94]
Hsu, D.Z.; Chen, K.T.; Li, Y.H.; Chuang, Y.C.; Liu, M.Y. Sesamol delays mortality and attenuates hepatic injury after cecal ligation and puncture in rats: role of oxidative stress. Shock, 2006, 25(5), 528-532.
[http://dx.doi.org/10.1097/01.shk.0000209552.95839.43] [PMID: 16680019]
[95]
Kim, J.Y.; Choi, D.S.; Jung, M.Y. Antiphoto-oxidative activity of sesamol in methylene blue- and chlorophyll-sensitized photo-oxidation of oil. J. Agric. Food Chem., 2003, 51(11), 3460-3465.
[http://dx.doi.org/10.1021/jf026056p] [PMID: 12744684]
[96]
Kaur, A.; Jindal, S.; Kaur, I.P.; Chopra, K. Effect of sesamol on the pathophysiological changes induced by surgical menopause in rodents. Climacteric, 2013, 16(4), 426-437.
[http://dx.doi.org/10.3109/13697137.2012.696292] [PMID: 23017032]
[97]
Ying, Z.; Kherada, N.; Kampfrath, T.; Mihai, G.; Simonetti, O.; Desikan, R.; Selvendiran, K.; Sun, Q.; Ziouzenkova, O.; Parthasarathy, S.; Rajagopalan, S. A modified sesamol derivative inhibits progression of atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2011, 31(3), 536-542.
[http://dx.doi.org/10.1161/ATVBAHA.110.219287] [PMID: 21183734]
[98]
KS, R.; Nayanatara, A.K.; Poojary, D.; Pai, S.R.; Chatterjee, P.K.; Bernhardt, L.K. Long term intake of sesamol increases epidydymal spermatocyte reserve in male wistar albino rats. Int. J. Recent Sci. Res., 2015, 6(1), 2415-2417.
[99]
Kondamudi, P.K.; Kovelamudi, H.; Mathew, G.; Nayak, P.G.; Rao, C.M.; Shenoy, R.R. Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats. Pharmacol. Rep., 2013, 65(3), 658-665.
[http://dx.doi.org/10.1016/S1734-1140(13)71043-0] [PMID: 23950588]

Rights & Permissions Print Cite
Article Metrics
58
2
1
World Chagas Disease
© 2024 Bentham Science Publishers | Privacy Policy