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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

Author(s): Dima A. Sabbah*, Rima Hajjo and Kamal Sweidan

Volume 20, Issue 10, 2020

Page: [815 - 834] Pages: 20

DOI: 10.2174/1568026620666200303123102

Price: $65


The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.

Keywords: EGFR, HER-1, ERBB-1, Tyrosine kinase, EGF, TGF-α, mAbs, Inhibitors, cancer.

Graphical Abstract
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