Generic placeholder image

Recent Patents on Nanotechnology


ISSN (Print): 1872-2105
ISSN (Online): 2212-4020

Review Article (Mini-Review)

Innovation Overview of Nanoparticle-Based Dermatological Products: A Patent Study

Author(s): Lucas A.G. da Costa, Myla L. de Souza*, André Luiz M.D. de Sousa, Emerson de O. Silva, Rosali M.F. da Silva, Larissa A. Rolim and Pedro J. Rolim-Neto

Volume 14 , Issue 2 , 2020

Page: [128 - 140] Pages: 13

DOI: 10.2174/1872210514666200214125222

Price: $65


Background: The health area in its most diverse fields has progressively incorporated nanotechnology into its products, such as in dermatology. In this sector, nanoparticles are one of the strategies that allow improvements, both in terms of value-added, as well as the efficacy, safety and stability of products for cosmetic or therapeutic purposes.

Objective: To understand the scenario of development and innovation of dermatological products with nanoparticles, through a patent prospection, evaluating the annual evolution, the main technology investors countries, the profile of the depositors, besides the uses and purposes of the products.

Methods: The Espacenet® database was used for consultation, using the search term "nanoparticle and skin". A total of 285 patents were found, of which 208 were available and 89 were based on the scope.

Results: There was a progressive evolution in the number of patents after the year 2000, with South Korea, the United States, China and Japan as the main depositor countries. Private companies and Education and Research Institutions were the entities with the largest amount of deposits. The cosmetic purpose was the predominant use compared to the therapeutic one. The most prominent nanoparticles were polymeric, metallic and lipid, while the therapeutic area presented a larger number of the functionalized ones.

Conclusion: The market for dermatological products has been innovating and growing over the years through the use of nanoparticles, evidencing a prominent development of nanotechnology-based cosmetics. Countries investing in nanotechnology and major developers of innovative products are highlighted in this scenario.

Keywords: Prospection, patent, nanotechnology, skin, dermatology, innovation.

Graphical Abstract
Hulla JE, Sahu SC, Hayes AW. Nanotechnology: History and future. Hum Exp Toxicol 2015; 34(12): 1318-21.
[] [PMID: 26614822]
Bhatia S. Natural polymer drug delivery systems: Nanoparticles, plants, and algae. Springer Switzerland 2016.
Ventola CL. Progress in nanomedicine: Approved and investigational nanodrugs. P&T 2017; 42(12): 742-55.
[PMID: 29234213]
Castagnola V, Polo E, Dawson KA. Understanding and characterizing functional properties of nanoparticles. pharmaceutical nano echnology: innovation and production. 1st ed. wiley-vch verlag gmbh co. kgaa 2017; pp. 63-80.
Mirza AZ, Siddiqui FA. Nanomedicine and drug delivery: A mini review. Int Nano Lett 2014; 4(1): 94.
Weissig V, Pettinger TK, Murdock N. Nanopharmaceuticals (part 1): Products on the market. Int J Nanomedicine 2014; 9: 4357-73.
[] [PMID: 25258527]
Antonio JR, Antônio CR, Cardeal ILS, Ballavenuto JMA, Oliveira JR. Nanotechnology in dermatology. An Bras Dermatol 2014; 89(1): 126-36.
[ ] [PMID: 24626657]
Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. J Control Release 2016; 240: 77-92.
[] [PMID: 26518723]
Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: An analysis of the prevalence and impact of skin conditions. J Invest Dermatol 2014; 134(6): 1527-34.
[] [PMID: 24166134]
Marino AD, Bowman DM, Sylvester DJ. The patent landscape of nanomedicines. Med Res Arch 2017; 5(9): 1-8.
OECD. OECD Science, Technology and industry outlook 2014: highlights. in: paris 2014.
Jia L. Global Governmental Investment in Nanotechnologies. Curr Nanosci 2005; 1(3): 263-6.
[] [PMID: 19865495]
Jackson Highsmith Nanoparticles in biotechnology, drug development and drug delivery: BIO113B | BCC Research.Global Markets 2014.
Zastrow M. South Korea’s Nobel dream. Nature 2016; 534(7605): 20-3.
[] [PMID: 27251257]
De Souza ML, Oliveira DD, Ribeiro PLL, de Paula Pereira N, Druzian JI. Nanoemulsions for cosmetic applications: What innovation status? Recent Pat Nanotechnol 2018; 12(2): 101-9.
[ ] [PMID: 29032764]
Jr JFS. The national nanotechnology initiative: Overview, reauthorization, and appropriations issues. Whasington 2014.
Qiu J. Nanotechnology development in China: Challenges and opportunities. Natl Sci Rev 2016; 3(1): 148-52.
Zagar AA. Nanotech Cluster and Industry Landscape in Japan 2014.
Rosenblatt M. How academia and the pharmaceutical industry can work together: The president’s lecture, annual meeting of the American Thoracic Society, San Francisco, California. Ann Am Thorac Soc 2013; 10(1): 31-8.
[ ] [PMID: 23509330]
Yeou KS, Hyeon BS, Chul PS, Kyun JB, Hyun MS, Hwan LT, et al. composition for skin-whitening comprising nanoparticle of callus derived from resveratrol-enriched rice. kr patent 20160029979, 2016.
P CG, P CH, Y CMV. Microbial cellulose nanoparticle, water and monolaurin delivery system. PH Patent 12016000365, 2017. 2017.
Yu X, Jianpeng W. preparation method for chitosan nanoparticle film spraying agent. CN Patent 104922053 2015.
Jiaquan L, Diping Z, Zikuan G, Xianguang C, Kaicheng Q, Li L. Preparing method and application of human mesenchymal stem cell source exosome bio-active preparation. CN Patent 106913583, 2017.
Haliza H, Iqbal MAMC, Shariza S, Fhataheya B. Chitosan-based skin-targeted nanoparticle drug delivery system and method. WO Patent 2015072846 2015.
Jian Z, Hui L, Xiaoyan F. Scalp and hair nursing agent. CN Patent 107789208 2018.
Nam KK, Jun LH, Chul CE, Jeong KE, Min CJ. Cosmetic composition for lip-plumpling. KR Patent 20080088888 2008.
Jeong LS, Chul KM, Soo LI. Compostion for functional soap comprising gold or silver nanoparticle and extraction polymer of black nightshade as effective ingredients, and production method thereof KR Patent 100847478 2008.
Jr BRW, Valerie A. Cosmetic formulations comprising ZNO nanoparticles. CA Patent 2562047 2005.
Peter B, Sudipta S. Coated nanoparticle therapy for skin cancer. US Patent 2013337070 2013.
Young LH, Hun SJ. Magnetic medical yarn. KR Patent 20160004071 2016.
Morones PG, Urbina BAP, Elizondo JAD, Galindo RB. Zinc oxide nanoparticles synthesis process to regenerate skin in wounds or cutaneous injuries. MX Patent 2017003889 2018.
Ferreira LS, Comune MA. composition of gold nanoparticles having antimicrobial peptides bound on their surface for use the treatment of wound healing or in the treatment of ischemic or vascular di-seases or in the treatment of skin disorders. US Patent 2018264134 2018.
Ruy MGH, Ernesto CRM. Flexible laminar material with ultraviolet absorbing filter. WO Patent 2012131125, 2012.
Magzinurovich KR, Sergeevich TG, Vladimirovna AM, Iskanderovich IS, Aleksandrovna TNJ. Method for introducing gold nanoparticles by local skin application. RU Patent 2500381 2013.
Hui HS, Wook YK, Ji BE. Mask pack comprising gold nanoparticle liquid composition. KR Patent 20170102738, 2017.
Hong KC, Min KH. Mud-loess pack composition and producing method thereof. KR Patent 20070075157 2007.
Hwa SY, Suk CB, Ho KD, Mook CB. Silk mask sheet containing the silver nanoparticles. KR Patent 20090105379 2009.
Seo LY. Effectively utilizing the platinum nano anti-aging mask sheet. KR Patent 20160126278 2016.
Rox AR. System for treating a sebaceous gland. US Patent 2017312314, 2017.
Won KD, Ho GI, Hoi KC, Woo KD, Ho LK, Su MJ. Pharmaceutical composition for treating inflammatory disease and immune disease comprising metal nanoparticles having anti-inflammatory activity as an effective ingredient KR Patent 20090080855, 2009.
Romain QR, Ignacio MC, Mark K. Method for enhanced photoepilation based on metallic nano-complexes US Patent 2014316394 2014.
Kyu KY, Lyeh PM, Hwa KE, Hyun LK. Cosmetic composition having antibiotic effect KR Patent 20100004483 2010.
Bum PS. Nanosoap containing silver nanoparticles US Patent 2010056485 2010.
Jae SY, Eun JM, Sup KD, Wook CS. Hybrid powder of halloysite nanotube and light-scattering nanoparticle, method for preparing the same, and UVscreening cosmetic composition containing the same as active ingredient US Patent 2013078293 2013.
Kyung SH. Mask pack composition for skin beauty and mask pack for skin beauty comprising the same KR Patent 20170056148 2017.
Mirkin CA, Paller AS, Giljohann DA. Delivery of oligonucleotidefunctionalized nanoparticles JP Patent 2018135393 2018.
Sik YE, Suk LJ. Coloidal solution of metal-particle having high efficiency of skin apsorption KR Patent 20090030753 2009.
Christian K, Claudia H, Marcel R, Soraya H, Christian U. Nanoparticle-containing peeling compositions WO Patent 02051376 2002.
Veronica K. Core-shell particles comprising a zinc oxide nanoparticle core coated with a shell containing silicon compound and titanium dioxide KR Patent 20140088391 2014.
Beom LJ, Wook HD, Youn HD, Wook LJ. Cosmetic composition for preventing skin aging comprising surface-modified gold nanoparticle by phytochemical KR Pa-tent 20120139229 2012.
Jon G, Phillip W, Meike R. Nanoparticles and their use in cancer therapy US Patent 2017340665, 2017.
Lianfang Z, Dissaya P. Triggered cargo release from nanoparticle stabilized liposomes US Patent 2013028962 2013.
Maitra P, Brown SE, Jr JRG, Rothouse J, Brahms JC, Fair MJ. Geltechnology suitable for use in cosmetic compostions. JP Patent 2016026152, 2016.
Nicolas R. Dermatological cosmetic composition comprising an SDKP peptide or an analog thereof WO Patent 2017140997 2017.
Kyu YB, Vijayakumar A. Novel tranexamic acid-loaded liquid crystalline nanoparticles and process for preparing the same KR Patent 101775266, 2017.
Hongjun WCT, Huihui R, Ling L, Zhaocheng M, Chunyu C. Application of guanidinated chitosan derivative and nanoparticle CN Patent 107266610, 2017.
Pao-Chi C, Yu-Sheng L, Jun-Hong C. Combined nanoparticle lipid carrier TW Patent 201806578, 2018.
Singh SM, Ram P. Novel nanoparticle formulations for skin delivery US Patent 2012195957 2012.
Teruyuki N. Skin-revitalizing cosmetic composition US Patent 2009098214, 2009.
Gang SH. Cosmetic composition containing nanoparticles of Phellinus Linteus extract KR Patent 20040033989, 2004.
Wang S, Zhou X, Yang Q, Sun J, Cao Y, Xie Y. New application of stilbene glucoside to preparation of skin ageing-resistant medicaments CN Patent 102614205 2012.
Yadong H, Qi X, Qiaoxue X, Yu B. Antibacterial peptide-chitosan compound as well as prepara-tion method and application thereof CN Patent 107997984, 2018.
Woo CJ, Jae SS, Hee JJ, Soo KJ. Nanoparticle containing poor soluble materials, method for preparation the nanoparticle, and cosmetic composition con-taining the nanoparticle KR Patent 20150093896, 2015.
Simon B, Taher N, Nour K, Amit B. Nanoparticles based on poly(lactic glycolic)acid for cosmetic applications US Patent 2013266625, 2013.
Sung SH, Myung JS, Seung KD. Complex scaffold comprising nanofiber with nanoparticle to drug-delivery for artificial skin and filler, and method for preparing the same KR Patent 20150007808 2015.
Sik KK, Seok CG, Sang KB. Cosmetic composition for enhancing skin penetration containing pH responsive nanoparticles and biomimetic surfactant KR Patent 20120001418 2012.
Douglas LA, Peter M. Photochemically stable, non-leaching sunscreens from epoxide-based silane coupling agents and UV absorbing chromop-hores US Patent 2018333347 2018.
Jun X, Shen Y, Tang S, Lu Y. Short interfering Ribonucleic Acid (siRNA) for promoting scar-less healing of skin wounds and application thereof. CN Pa-tent 102031260 2011.
Lili C, Jian J, Yuanyuan L, Xin G, Ping H. 5-fluorouracil nanoparticle transdermal drug delivery electret preparation for treating hypertrophic scars based on action of electric field CN Patent 105816442, 2016.
Krishnan C, Robert S, Tracey I, Siddhartha K. Nanoparticle mediated therapy, diagnostic products and therapeutic products for breast cancer US Patent 2013330279 2013.
Mi HY, Yeol KH, Su KS, Cheol SB. Coating method of surface of nanoparticle used for cosmetic material. KR Patent 20030091539 2003.
Nancy M. Methods and compositions for skin regeneration WO Patent 2011044367, 2011.
Takesuke T, Yohei B, Kaori H, Hiroyuki T. Method for producing tranexamic acid-containing nanoparticle and composite particle JP Patent 2010180145, 2010.
Bu KY, Hui KJ, Young YT, Min KJ, Sik HS. Preparing method of dermatropic nanoparticle of polylactide-glicolide. KR Patent 20110092484, 2011.
Sik KK, Min LS, Sang KB. pH responsive nano particles as stabilizer of functional cosmetic agent. KR Patent 100925188 2009.
Hiroki F, Noriyuki Y, Nobuyuki S, Kiyoshi I, Kenshiro S. Cosmetic containing cationic nanoparticle. JP Patent 2005336100, 2005.
Hiroki F, Yoshimi S, Diasuke K, Yoshitetsu K, Atsuhiko O, Kenshiro S. Cosmetic, nanoparticle for cosmetic and powder for cosmetic JP Patent 2007119374, 2007.
Sang KS, Hee YB, Sung NY, Hwan KB, Seok KB, Seop CI, et al. Percutaneous absorbent using polymer nanoparticle and external preparation containing the same P Patent 2002308728, 2002.
Yong KH, Jin LY, Hyun CS. A supercritical nanoparticle process with ceramide using mo-lecular association theory KR Patent 20090070846, 2009.
Sam SS, Jin LY, Yong KW. A supercritical nanoparticle process with vitamin K using molecular association theory. KR Patent 100802278 2008.
Benwu M. Nanoparticle transdermal absorption technology CN Patent 105168025, 2015.
Lishun B, Pengfei Z, Janwei Y, Weichao L, Xing W. Herbal compound skin-whitening agent nanoparticle prepara-tion method CN Patent 107049863, 2017.
Cheol KH, Koo HH, Joo LH, Jin JH, Hyun PS. siRNA siRNA hydrogel-based nanoparticles for the treatment of atopic dermatitis method for preparing the same KR Patent 101706047 2017.
Raffin PA, Staniscuaski GS, Alessandro J. Nanoparticle system comprising oil and UV filter US Patent 2016256372 2016.
Jonathan B. Cannabinoid receptor biding agents, compositions and methods EP Patent 2995302 2016.
Fassih A, Paturi J, Talbot JW. Topical composition containing cross-linked glycosaminoglycan. JP Patent 2017197520 2017.
Thomas F, Armin W, Christian K, Hans D, Marcus C. Flexible, absorbent carriers containing nanoparticle disper-sions for treating the skin WO Patent 0054733 2000.
Hermod AG. Acetic acid and hypochlorous acid compositions for treatment of biofilms and wound care. US Patent 2017266227 2017.
Jonathan E, Timothy K. Peptide nanoparticles and uses thereof CN Patent 107080703, 2017.
Janette APP. Bioproduct based on selenium nanoparticles in a honey matrix for the treatment of complex injuries and dermatological infections. WO Patent 2018176168
Yong CG, Su CJ, Yong ES, Su JU, Ho KG, Su KG, et al. Antiwrinkle cosmetic composition. KR Patent 20040011881, 2004.
Yong PC, Kee HK, Chan YJ. Inflammation and wound treatment complex for controlled delivery of a dual-loaded drug. KR Patent 20180033063, 2018.
Salan HNM. AOEM Mohammad AK. Organonsilicon compounds, fatty acids and oils with homogenous silicon nanoparticle dispersions WO Patent 2010059604, 2010.
Allan PC, Spomenka S, Ghouch EN. Nanoparticle-coated capsule formulation for dermal drug delivery. US Patent 2010136124, 2010.
Won KJ. Moisturizing patches comprising silica-containing complex nanoparticle. CN Patent 105726353, 2016.
Lisa D, Samreen J, Brian P. Nanoparticle therapeutics for treating skin inflammatory disorders US Patent 2018296491, 2018.
Won KJ. Silica-containing complex nanoparticle and hydrogel moisturizing patches comprising the same. KR Patent 101528741, 2015.
Jonathan E, Timothy K, Klaus T. Nanoparticle compositions and components thereof US. Patent 2017087088, 2017.
Soo LG, Bae PH, Young OJ, Hoon KT, Boo CT. Cosmetic composition using bisethylhexyloxyphenol-methoxyphenyltriazine loaded solid lipid capsule. KR Patent 20090075299, 2009.
Lu H, Chen B. Anti-aging lipid nanoparticle emulsion for skin and preparation method thereof. CN Patent 102784084, 2012.
Wook YJ, Young CH, Ryong MH, Amin MA. MHY498 Solid lipid nanoparticles composition for skin-whitening effect comprising MHY498 and preparation method thereof. KR Patent 20180029413, 2018.
Majumdar S, Samanta SK, Sarkar S. Acyclovir loaded solid lipid nano particulate gel formulation for topical application and method of formulating the same IN Patent 26KO2014, 2015.
Qiang X. Phenylethyl resorcinol lipid nanoparticle as well as preparation method and use thereof. CN Patent 104523442, 2015.
Zhong H, Liu M. Calcipotriol solid lipid nanoparticle and preparation method of same. CN Patent 102342914 2012.
Pei W, Li R, Wang N, Yan X, Zeng J. Titanic oxide solid lipid nano granule, fluid dispersion and preparation method thereof. CN Patent 101496779, 2009.
Kumar POP, Satheesh AR, Mohammed PA. Protein nano carriers for topical delivery. US Patent 2012195947 2012.
Orbis Research Global Cosmetics Products Market-Analysis of Growth, Trends and Forecasts (2018-2023) 2018.
Grand View Research Nanomedicine Market Size, Growth | Global Industry Report, 2018-2025 2017.
Raphael AP, Garrastazu G, Sonvico F, Prow TW. Formulation design for topical drug and nanoparticle treatment of skin disease. Ther Deliv 2015; 6(2): 197-216.
[] [PMID: 25690087]
Tanghetti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol 2013; 6(9): 27-35.
[PMID: 24062871]
Connolly D, Vu HL, Mariwalla K, Saedi N. Acne scarring-pathogenesis, evaluation, and treatment options. J Clin Aesthet Dermatol 2017; 10(9): 12-23.
[PMID: 29344322]
Ramos-E-Silva M Celem LR, Ramos-E-Silva S, Fucci-Da-Costa AP. Anti-aging cosmetics: Facts and controversies. Clin Dermatol 2013; 31: 750-8.
Niska K, Zielinska E, Radomski MW, Inkielewicz-Stepniak I. Metal nanoparticles in dermatology and cosmetology: Interactions with human skin cells. Chem Biol Interact 2018; 295: 38-51.
[] [PMID: 28641964]
Bhatia S. Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications natural polymer drug delivery systems. Cham: Springer International Publishing 2016; pp. 33-93.
McSweeney PC. The safety of nanoparticles in sunscreens: An update for general practice. Aust Fam Physician 2016; 45(6): 397-9.
[PMID: 27622230]
Estanqueiro M, Conceição J, Amaral MH, Sousa Lobo JM. The role of liposomes and lipid nanoparticles in the skin hydration nano biomaterials in galenic formulations and cosmetics: Applications of nanobiomaterials. Oxford: Elsevier Inc. 2016; pp. 297-326.
Mishra N, Pant P, Porwal A, Jaiswal J, Samad MA, Tiwari S. Targeted drug delivery system: A review. Am J Pharmatec Res 2016; 6(1): 1-24.

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy