Abstract
Genetic instability often leads to tumourogenesis. Genomic alterations such as deletions of a chromosome region containing a tumour suppresser gene or amplification of a region containing an oncogene have been frequently found to be associated with the initiation and the progression of cancer. Therefore identification of chromosomal regions amplified or deleted in tumour cells may reveal the presence of such genes. Amplification of 20q13 for instance is frequently observed in breast cancer cells. This region contains a gene encoding a protein kinase that belongs to the Aurora/Ipl1p-related kinase family involved in microtubule dependent mitotic events that control chromosome segregation. Deregulation of these kinases perturbs the ploidy of the cells. The human genome encodes at least three different kinases that have been found to be overexpressed in different tumour cells. But only the ectopic overexpression of the kinase encoded by the gene located at 20q13 is capable to transform cultured cells an d induce the apparition of tumours in nude mouse. In this manuscript we describe the function of the three human Aurora/Ipl1p-related kinases, and review the genomic alterations reported for the chromosome region where the kinase genes localise. But we first discuss the impact of the human genome sequence project for the identification of new kinases in the context of cancer research.
Keywords: Aurora, Ipl1p Related Kinases, CDNA microarrays, Cellular apoptosis susceptibility, HsAIRK1, Xenopus laevis, HsAIRK2, HsAIRK3
Current Genomics
Title: Human Aurora / Ipl1p Related Kinases
Volume: 1 Issue: 3
Author(s): P. Sanseau, M. Bernard, Y. Arlot-Bonnemains and C Prigent
Affiliation:
Keywords: Aurora, Ipl1p Related Kinases, CDNA microarrays, Cellular apoptosis susceptibility, HsAIRK1, Xenopus laevis, HsAIRK2, HsAIRK3
Abstract: Genetic instability often leads to tumourogenesis. Genomic alterations such as deletions of a chromosome region containing a tumour suppresser gene or amplification of a region containing an oncogene have been frequently found to be associated with the initiation and the progression of cancer. Therefore identification of chromosomal regions amplified or deleted in tumour cells may reveal the presence of such genes. Amplification of 20q13 for instance is frequently observed in breast cancer cells. This region contains a gene encoding a protein kinase that belongs to the Aurora/Ipl1p-related kinase family involved in microtubule dependent mitotic events that control chromosome segregation. Deregulation of these kinases perturbs the ploidy of the cells. The human genome encodes at least three different kinases that have been found to be overexpressed in different tumour cells. But only the ectopic overexpression of the kinase encoded by the gene located at 20q13 is capable to transform cultured cells an d induce the apparition of tumours in nude mouse. In this manuscript we describe the function of the three human Aurora/Ipl1p-related kinases, and review the genomic alterations reported for the chromosome region where the kinase genes localise. But we first discuss the impact of the human genome sequence project for the identification of new kinases in the context of cancer research.
Export Options
About this article
Cite this article as:
Sanseau P., Bernard M., Arlot-Bonnemains Y. and Prigent C, Human Aurora / Ipl1p Related Kinases, Current Genomics 2000; 1 (3) . https://dx.doi.org/10.2174/1389202003351355
DOI https://dx.doi.org/10.2174/1389202003351355 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nuclear Imaging and Early Breast Cancer Detection
Current Radiopharmaceuticals Dietary Phytochemicals in Chemoprevention of Cancer
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Copper Complexes of 8-Aminoquinoline and Uracils as Novel Aromatase Inhibitors
Letters in Drug Design & Discovery Teaching Pharmacogenetics in Low and Middle Income Countries (LMICs): An Empirical Study of the Lessons Learned
Current Pharmacogenomics and Personalized Medicine Endogenous Chemical Mediators in Anti-Inflammation and Pro-Resolution
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update
Mini-Reviews in Medicinal Chemistry Design of Peptide Imaging Agents for Whole-body and Intraoperative Molecular Imaging
Current Medicinal Chemistry The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery
Current Topics in Medicinal Chemistry Proteomics Studies in Oncology Towards Personalized Medicine in Public Health: Opportunities and Challenges for OMICS Research in Iran
Current Pharmacogenomics and Personalized Medicine Contribution of Magnetic Resonance Imaging in Determining Lumpectomy Cavity in Breast Radiotherapy
Current Medical Imaging Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy
Current Cancer Drug Targets Discovery of Lansoprazole and its Unique Pharmacological Properties Independent from Anti-secretory Activity
Current Pharmaceutical Design Emerging Role of Mucins in Epithelial to Mesenchymal Transition
Current Cancer Drug Targets Synthesis and Evaluation of Thiazolidinedione-Coumarin Adducts as Antidiabetic, Anti-Inflammatory and Antioxidant Agents
Letters in Organic Chemistry Application of High Performance Liquid Chromatography for Hydrolytic Stability Assessment of Selected Antibiotics in Aqueous Environment
Current Analytical Chemistry Chemoprotective Mechanism of the Natural Compounds, Epigallocatechin- 3-O-Gallate, Quercetin and Curcumin Against Cancer and Cardiovascular Diseases
Current Medicinal Chemistry Augmentation Therapy with Alpha1-antitrypsin: Novel Perspectives
Cardiovascular & Hematological Disorders-Drug Targets Production, Novel Assay Development and Clinical Applications of Monoclonal Antibodies
Recent Patents on Anti-Cancer Drug Discovery Do Chromatin Interaction Networks Radiate Pathogenic Contagion in the Genome?
Epigenetic Diagnosis & Therapy (Discontinued) Small Heat Shock Proteins (sHSPs) As Potential Drug Targets
Current Pharmaceutical Biotechnology