Generic placeholder image

Current Neurovascular Research


ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

Research Article

Early Age of Migraine Onset is Independently Related to Cognitive Decline and Symptoms of Depression Affect Quality of Life

Author(s): Jiajia Bao, Mengmeng Ma, Shuju Dong, Lijie Gao, Changling Li, Chaohua Cui, Ning Chen, Yang Zhang and Li He*

Volume 17, Issue 2, 2020

Page: [177 - 187] Pages: 11

DOI: 10.2174/1567202617666200207130659

open access plus


Background: People with migraine experience cognitive decline more often than healthy controls, resulting in a significant functional impact. Early identifying influencing factors that contribute to cognitive decline in migraineurs is crucial for timely intervention. Although migraine may onset early in childhood and early onset migraine is related to significant disability, there is no research investigating the association between the age of migraine onset and migraineurs’ cognitive decline. Therefore we aim to explore possible factors that correlate to the cognitive function of migraineurs, especially focus on age of migraine onset.

Methods: 531 patients with migraine were included. Data on demographics and headache-related characteristics were collected and evaluated using face-to-face interviews and questionnaires. We used the Montreal Cognitive Assessment scale to assess cognitive function. In addition, we analyzed independent correlations between cognitive decline and the age of migraine onset in patients with migraine. And all patients completed the Headache Impact Test-6 to evaluate their quality of life.

Results: Migraineurs with cognitive decline showed significant differences from those without in age (OR=1.26, P<0.0001), years of education (OR=0.89, P=0.0182), the intensity of headache (OR=1.03, P=0.0217), age of onset (OR=0.92, P<0.0001) and anxiety scores (OR=1.09, P=0.0235). Furthermore, there was no interaction in the age of onset between subgroups. Multivariate linear regression analyses of HIT-6 scores showed that the intensity of headache (β=0.18, P<0.0001) and depression scores (β=0.26, P=0.0009) had independent effects on decreased quality of life.

Conclusion: Our findings suggest that younger age of migraine onset is independently related to migraineurs’ cognitive decline, and migraine accompanying anxiety symptoms significantly related to decreased quality of life in migraineurs.

Keywords: Migraine, headache, age of migraine onset, cognitive function, cognitive decline, quality of life, anxiety symptom, depression symptom.

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392(10159): 1789-858.
[] [PMID: 30496104]
GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019; 18(5): 459-80.
[] [PMID: 30879893]
Huang L, Juan Dong H, Wang X, Wang Y, Xiao Z. Duration and frequency of migraines affect cognitive function: Evidence from neuropsychological tests and event-related potentials. J Headache Pain 2017; 18(1): 54.
[] [PMID: 28477306]
Santangelo G, Russo A, Trojano L, et al. Cognitive dysfunctions and psychological symptoms in migraine without aura: A cross sectional study. J Headache Pain 2016; 17(1): 76.
[] [PMID: 27568039]
Munir F, Jones D, Leka S, Griffiths A. Work limitations and employer adjustments for employees with chronic illness. Int J Rehabil Res 2005; 28(2): 111-7.
[] [PMID: 15900180]
Lerner DJ, Amick BC III, Malspeis S, et al. The migraine work and productivity loss questionnaire: Concepts and design. Qual Life Res 1999; 8(8): 699-710.
[] [PMID: 10855344]
Lee SH, Kang Y, Cho SJ. Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality. J Headache Pain 2017; 18(1): 77.
[] [PMID: 28744704]
Huang L, Juan Dong H, Wang X, Wang Y, Xiao Z. Duration and frequency of migraines affect cognitive function: Evidence from neuropsychological tests and event-related potentials. J Headache Pain 2017; 18(1): 54.
[] [PMID: 28477306]
Abdulkadir T, Kaya TA, Doan GB, et al. Cognitive performance in young and middle-aged adults with migraine: Investigating the correlation with white matter hyperintensities and psychological symptoms. Neurol Neurochir Polska 2018; 52(4): 470-6.
Balottin U, Termine C, Nicoli F, Quadrelli M, Ferrari-Ginevra O, Lanzi G. Idiopathic headache in children under six years of age: A follow-up study. Headache 2005; 45(6): 705-15.
[] [PMID: 15953303]
Fuh JL, Wang SJ, Lu SR, Liao YC, Chen SP, Yang CY. Headache disability among adolescents: A student population-based study. Headache 2010; 50(2): 210-8.
[] [PMID: 19804389]
Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders. 3rd edition (beta version) Cephalalgia 2013; 33: 629-808.
Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders. 3rd edition Cephalalgia 2018; 38: 1-211.
Stewart WF, Lipton RB, Kolodner KB, Sawyer J, Lee C, Liberman JN. Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers. Pain 2000; 88(1): 41-52.
[] [PMID: 11098098]
Shin HE, Park JW, Kim YI, Lee KS. Headache Impact Test-6 (HIT-6) scores for migraine patients: Their relation to disability as measured from a headache diary. J Clin Neurol 2008; 4(4): 158-63.
[] [PMID: 19513291]
Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6(4): 278-96.
[] [PMID: 6080235]
Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32(1): 50-5.
[] [PMID: 13638508]
Collins SL, Moore RA, McQuay HJ. The visual analogue pain intensity scale: What is moderate pain in millimetres? Pain 1997; 72(1-2): 95-7.
[] [PMID: 9272792]
Organization W H. Obesity. Preventing and managing the global epidemic. Report of A Who Consultation on Obesity 1999; 15(1): 18-30.
Tu J, Wang L-X, Wen H-F, Xu YC, Wang PF. The association of different types of cerebral infarction with post-stroke depression and cognitive impairment. Medicine (Baltimore) 2018; 97(23)e10919
[] [PMID: 29879031]
Pucite E, Krievina I, Miglane E, Erts R, Krievins D, Millers A. Changes in cognition, depression and quality of life after carotid stenosis treatment. Curr Neurovasc Res 2019; 16(1): 47-62.
[] [PMID: 30706811]
Helmstaedter C, Witt JA. Epilepsy and cognition - A bidirectional relationship? Seizure 2017; 49: 83-9.
[] [PMID: 28284559]
Walker KA, Power MC, Gottesman RF. Defining the relationship between hypertension, cognitive decline, and dementia: A review. Curr Hypertens Rep 2017; 19(3): 24.
[] [PMID: 28299725]
Abner EL, Nelson PT, Schmitt FA, et al. Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort. Dement Geriatr Cogn Disord 2014; 37(5-6): 294-306.
[] [PMID: 24401791]
Ali FS, Hussain MR, Gutiérrez C, et al. Cognitive disability in adult patients with brain tumors. Cancer Treat Rev 2018; 65: 33-40.
[] [PMID: 29533821]
O’Callaghan C, Lewis SJG. Cognition in Parkinson’s disease. Int Rev Neurobiol 2017; 133: 557-83.
[] [PMID: 28802933]
Guerreiro MJS, Van Gerven PWM. Disregarding hearing loss leads to overestimation of age-related cognitive decline. Neurobiol Aging 2017; 56: 180-9.
[] [PMID: 28559106]
Mattay VS, Fera F, Tessitore A, et al. Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett 2006; 392(1-2): 32-7.
[] [PMID: 16213083]
Salthouse TA. When does age-related cognitive decline begin? Neurobiol Aging 2009; 30(4): 507-14.
[] [PMID: 19231028]
R?Nnlund M, Nyberg L, B?Ckman L, et al. Stability, growth, and decline in adult life span development of declarative memory: Cross-sectional and longitudinal data from a population-based study. Psychology and Aging 2005; 20(1): 3-18.
Aartsen MJ, Smits CHM, van Tilburg T, Knipscheer KC, Deeg DJ. Activity in older adults: cause or consequence of cognitive functioning? A longitudinal study on everyday activities and cognitive performance in older adults. J Gerontol B Psychol Sci Soc Sci 2002; 57(2): 153-62.
[] [PMID: 11867663]
Bigal ME, Kurth T, Santanello N, et al. Migraine and cardiovascular disease. A call for action. Headache 2010; 50(5): 882-3.
[] [PMID: 20546322]
Adelborg K, Szépligeti SK, Holland-Bill L, et al. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ 2018; 360: k96.
[] [PMID: 29386181]
Colon E, Ludwick A, Wilcox SL, et al. Migraine in the young brain: adolescents vs. young adults. Front Hum Neurosci 2019; 13: 87.
[] [PMID: 30967767]
Arenaza-Urquijo EM, Gonneaud J, Fouquet M, et al. Interaction between years of education and APOE ε4 status on frontal and temporal metabolism. Neurology 2015; 85(16): 1392-9.
[] [PMID: 26408498]
Meng X, D’Arcy C. Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors. Int J Geriatr Psychiatry 2013; 28(10): 1005-14.
[] [PMID: 23255503]
Van Gerven PW, Meijer WA, Jolles J. Education does not protect against age-related decline of switching focal attention in working memory. Brain Cogn 2007; 64(2): 158-63.
[] [PMID: 17397977]
Camarda C, Monastero R, Pipia C, Recca D, Camarda R. Interictal executive dysfunction in migraineurs without aura: Relationship with duration and intensity of attacks. Cephalalgia 2007; 27(10): 1094-100.
[] [PMID: 17711495]
Calandre EP, Bembibre J, Arnedo ML, Becerra D. Cognitive disturbances and regional cerebral blood flow abnormalities in migraine patients: Their relationship with the clinical manifestations of the illness. Cephalalgia 2002; 22(4): 291-302.
[] [PMID: 12100092]
Facco E, Munari M, Baratto F, et al. Regional cerebral blood flow (rCBF) in migraine during the interictal period: different rCBF patterns in patients with and without aura. Cephalalgia 1996; 16(3): 161-8.
[] [PMID: 8734767]
Tomé-Pires C, Solé E, Racine M, et al. The relative importance of anxiety and depression in pain impact in individuals with migraine headaches. Scand J Pain 2016; 13: 109-13.
[] [PMID: 28850506]
Liguori C, Pierantozzi M, Chiaravalloti A, et al. When cognitive decline and depression coexist in the elderly: CSF biomarkers analysis can differentiate alzheimer’s disease from late-life depression. Front Aging Neurosci 2018; 10: 38.
[] [PMID: 29527163]
Sehmbi M, Rowley CD, Minuzzi L, et al. Age-related deficits in intracortical myelination in young adults with bipolar disorder type I. J Psychiatry Neurosci 2019; 44(2): 79-88.
[] [PMID: 30525334]
Cesare Galimberti, Francesca Bosi Monica, Valentina Caricasole, et al. Using network analysis to explore cognitive domains in patients with unipolar versus bipolar depression: a prospective naturalistic study. CNS Spectr 2019; 1-12. undefined
Iverson GL, Brooks BL, Langenecker SA, Young AH. Identifying a cognitive impairment subgroup in adults with mood disorders. J Affect Disord 2011; 132(3): 360-7.
[] [PMID: 21439647]
Sinoff G, Werner P. Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. Int J Geriatr Psychiatry 2003; 18(10): 951-9.
[] [PMID: 14533128]
Banks SJ, Raman R, He F, et al. The Alzheimer’s disease cooperative study prevention instrument project: Longitudinal outcome of behavioral measures as predictors of cognitive decline. Dement Geriatr Cogn Disord Extra 2014; 4(3): 509-16.
[] [PMID: 25685141]
Freedman M, Black S, Ebert P, Binns M. Orbitofrontal function, object alternation and perseveration. Cereb Cortex 1998; 8(1): 18-27.
[] [PMID: 9510382]
Fincham JM, Carter CS, van Veen V, Stenger VA, Anderson JR. Neural mechanisms of planning: A computational analysis using event-related fMRI. Proc Natl Acad Sci USA 2002; 99(5): 3346-51.
[] [PMID: 11880658]
Guidetti V, Faedda N, Siniatchkin M. Migraine in childhood: Biobehavioural or psychosomatic disorder? J Headache Pain 2016; 17(1): 82.
[] [PMID: 27619362]
Liu J, Zhao L, Li G, et al. Hierarchical alteration of brain structural and functional networks in female migraine sufferers. PLoS One 2012; 7(12); e51250.
[] [PMID: 23227257]
Mainero C, Boshyan J, Hadjikhani N. Altered functional MRI resting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol 2011; 70(5): 838-45.
[] [PMID: 22162064]
Coppola G, Di Renzo A, Tinelli E, et al. Resting state connectivity between default mode network and insula encodes acute migraine headache. Cephalalgia 2018; 38(5): 846-54.
[PMID: 28605972]
Androulakis XM, Krebs KA, Jenkins C, et al. Central executive and default mode network intranet work functional connectivity patterns in chronic migraine. J Neurol Disord 2018; 6(5): 6.
[] [PMID: 30574520]
Xue T, Yuan K, Zhao L, et al. Intrinsic brain network abnormalities in migraines without aura revealed in resting-state fMRI. PLoS One 2012; 7(12); e52927.
[] [PMID: 23285228]
Tessitore A, Russo A, Giordano A, et al. Disrupted default mode network connectivity in migraine without aura. J Headache Pain 2013; 14(1): 89.
[] [PMID: 24207164]
Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci USA 2004; 101(13): 4637-42.
[] [PMID: 15070770]
Marek S, Hwang K, Foran W, Hallquist MN, Luna B. The Contribution of Network Organization and Integration to the Development of Cognitive Control. PLoS Biol 2015; 13(12) e1002328.
[] [PMID: 26713863]
Stevens MC. The contributions of resting state and task-based functional connectivity studies to our understanding of adolescent brain network maturation. Neurosci Biobehav Rev 2016; 70: 13-32.
[] [PMID: 27502750]
Magnusson JE, Becker WJ. Migraine frequency and intensity: relationship with disability and psychological factors. Headache 2003; 43(10): 1049-59.
[] [PMID: 14629240]
Lantéri-Minet M, Radat F, Chautard MH, Lucas C. Anxiety and depression associated with migraine: influence on migraine subjects’ disability and quality of life, and acute migraine management. Pain 2005; 118(3): 319-26.
[] [PMID: 16289799]

© 2022 Bentham Science Publishers | Privacy Policy