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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Mini-Review Article

Cross-talk of Signaling Pathways in the Pathogenesis of Allergic Asthma and Cataract

Author(s): Yang Zhao, Sumei Liu, Xiangsheng Li, Zhenzhen Xu , Lifang Hao, Zhe Cui, Kewei Bi, Yanfen Zhang* and Zhongcheng Liu*

Volume 27, Issue 9, 2020

Page: [810 - 822] Pages: 13

DOI: 10.2174/0929866527666200207113439

Price: $65


Allergic asthma is a chronic inflammatory disease, which involves many cellular and cellular components. Cataract is a condition that affects the transparency of the lens, which the opacity of the lens caused by any innate or acquired factor degrades its transparency or changes in color. Both of them belong to diseases induced by immune disorders or inflammation. We want to confirm the signaling pathways involved in the regulation of asthma and cataract simultaneously, and provide reference for the later related experiments. So we conducted a scoping review of many databases and searched for studies (Academic research published in Wiley, Springer and Bentham from 2000 to 2019) about the possible relationship between asthma and cataract. It was found that during the onset of asthma and cataract, Rho/Rock signaling pathway, Notch signaling pathway, Wnt/β-catenin signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, MAPK signaling pathway, TGF-β1/Smad signaling pathway and NF-κB signaling pathway are all active, so they may have a certain correlation in pathogenesis. Asthma may be associated with cataract through the eight signaling pathways, causing inflammation or immune imbalance based on allergy that can lead to cataract. According to these studies, we speculated that the three most likely signaling pathways are PI3K/AKT, MAPK and NF-κB signaling pathway.

Keywords: Allergy, asthma, cataract, signaling pathway, pathogenesis, inflammation, immune imbalance.

Graphical Abstract
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