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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Research Article

Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity

Author(s): Najam Ali Khan*, Chitra Tomar, Alankar Shrivastav, Aftab Ahmad and Arun Kumar Mishra

Volume 18, Issue 1, 2021

Published on: 27 January, 2020

Page: [120 - 126] Pages: 7

DOI: 10.2174/1570163817666200128100631

Price: $65


Aims: The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models.

Background: Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In order to treat the diarrhea, natural drugs may be useful.

Objective: In order to prove the traditional claim of Ficus retusa, present work was undertaken with objective to prove antidiarrheal and antispasmodic activity.

Methods: The anti-diarrhoeal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine(5HT) induced diarrhea. Further, the exact were subjected to gastrointestinal motility test using standard procedure.

Result: Finding of the present study suggested that significant response was exhibited by ethanolic extract (400mg/kg bw.) of Ficus retusa.

Conclusion: The response towards bioactivity was dose dependent. It was concluded that 400mg/kg bw of ethanolic extract is most potent in antidiarrhoeal and antispasmodic activity.

Keywords: Diarrhea, Ficus retusa, magnesium sulphate, 5-HT induced, anti-spasmodic, natural drugs.

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