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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Research Article

Access to a Library of 1,3-disubstituted-1,2,3-triazenes and Evaluation of their Antimicrobial Properties

Author(s): Insa Seck, Samba F. Ndoye, Lalla A. Ba, Alioune Fall, Abdoulaye Diop, Ismaïla Ciss, Abda Ba, Cheikh Sall, Amadou Diop, Cheikh S. Boye, Generosa Gomez, Yagamare Fall* and Matar Seck*

Volume 20, Issue 9, 2020

Page: [713 - 719] Pages: 7

DOI: 10.2174/1568026620666200127143005

Price: $65


Background: Due to the rapid development of microbial resistance, finding new molecules became urgent to counteract this problem.

Objective: The objective of this work is to access 1,2,3-triazene-1,3-disubstituted, a class of molecule with high therapeutic potential.

Methods: Here we describe the access to 17 new triazene including six with an imidazole-1,2,3-triazene moiety and eleven with an alkyl-1,2,3-triazene moiety and their evaluation against five strains: two gram (-): Escherichia coli ATCC 25921 and Pseudomonas aeruginosa ATCC 27253; two gram (+) : Staphylococcus aureus ATCC 38213 and Enterococcus faecalis ATCC 29212; and one fungi: Candida albicans ATCC 24433.

Results: All strains were sensitive and the best MIC, 0.28 µM, is observed for 4c against Escherichia coli ATCC 25921. Compound 9, 3-isopropynyltriazene, appears to be the most interesting since it is active on the five evaluated strains with satisfactory MIC 0.32 µM against Escherichia coli and Pseudomonas aeruginosa and 0.64 µM against Enterococcus faecalis and Pseudomonas aeruginosa.

Conclusion: Comparing the structure activity relationship, electron withdrawing groups appear to increase antimicrobial activity.

Keywords: Strains, Resistance, Triazene, Antimicrobial, Minimal inhibitory concentrations, Bacterial infections.

Graphical Abstract
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