Objective: The aim of this study areto screen MicroRNAs (miRNAs) related to the prognosis of lung adenocarcinoma (LUAD) and to explore the possible molecular mechanisms.
Methods: The data for a total of 535 patients with LUAD data were downloaded from The Cancer Genome Atlas (TCGA) database. The miRNAs for LUAD prognosis were screened by both Cox risk proportional regression model and Last Absolute Shrinkage and Selection Operator (LASSO) regression model. The performances of the models were verified by time-dependent Receiver Operating Characteristic (ROC) curve. The possible biological processes linked to the miRNAs’ target genes were analyzed by Gene Ontology (GO), Kyoto gene and genome encyclopedia (KEGG).
Results: Among 127 differentially expressed miRNAs identified from the screening analysis, there are 111 up-regulated and 16 down-regulated miRNAs. Three of them, hsa-miR-1293, hsa-miR-490 and hsa-miR- 5571, were also significantly associated with the survival of the LUAD patients. The targets of the three miRNAs are significantly enriched in systemic lupus erythematosus pathways.
Conclusion: Hsa-miR-1293, hsa-miR-490 and hsa-miR-5571 can be potentially used as novel biomarkers for the prognosis prediction of LUAD.
[http://dx.doi.org/10.1111/j.1440-1843.2011.02095.x] [PMID: 22040022]
[http://dx.doi.org/10.7717/peerj.7353] [PMID: 31380150]
(b)Ma, T.; Hu, Y.; Guo, Y.; Yan, B. Tumor-promoting activity of long noncoding RNA LINC00466 in lung adenocarcinoma via miR-144-regulated HOXA10 axis. Am. J. Pathol., 2019, 189(11), 2154-2170.
[http://dx.doi.org/10.1016/j.ajpath.2019.06.014] [PMID: 31381886]
[http://dx.doi.org/10.3390/ijms20030510] [PMID: 30691046]
[http://dx.doi.org/10.1186/s40246-019-0212-8] [PMID: 31196165]
[http://dx.doi.org/10.1093/nar/gku1003] [PMID: 25352553]
[http://dx.doi.org/10.1101/gr.132662.111] [PMID: 22613842]
(b)Ou, S.H.; Zell, J.A.; Ziogas, A.; Anton-Culver, H. Prognostic factors for survival of stage I nonsmall cell lung cancer patients: a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003. Cancer, 2007, 110(7), 1532-1541.
[http://dx.doi.org/10.1002/cncr.22938] [PMID: 17702091]
[http://dx.doi.org/10.3892/ol.2019.10045] [PMID: 30881499]
(b)Hu, W.B.; Wang, L.; Huang, X.R.; Li, F. MicroRNA-204 targets SOX4 to inhibit metastasis of lung adenocarcinoma. Eur. Rev. Med. Pharmacol. Sci., 2019, 23(4), 1553-1562.
(c)Dai, B.; Kong, D.L.; Tian, J.; Liu, T.W.; Zhou, H.; Wang, Z.F. microRNA-1205 promotes cell growth by targeting APC2 in lung adenocarcinoma. Eur. Rev. Med. Pharmacol. Sci., 2019, 23(3), 1125-1133.
[http://dx.doi.org/10.1002/path.2962] [PMID: 21984125]
[http://dx.doi.org/10.1371/journal.pone.0104839] [PMID: 25126847]
[http://dx.doi.org/10.1111/1759-7714.12317] [PMID: 27148421]