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ISSN (Online): 1873-4286

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Review Article

Bioactivity of the Geranium Genus: A Comprehensive Review

Author(s): Vânia C. Graça, Isabel C.F.R. Ferreira and Paulo F. Santos*

Volume 26, Issue 16, 2020

Page: [1838 - 1865] Pages: 28

DOI: 10.2174/1381612826666200114110323

Price: $65

Abstract

Background: Plants from the Geranium genus, which comprises about 400 species, have been used since ancient times in the practice of traditional medicines throughout the world. Therefore, herbal preparations based on Geranium species have found wide usage for the treatment of a variety of ailments. The aim of this work is to present a review, as comprehensive as possible, of the studies concerning different biological activities of Geranium species.

Methods: Relevant data were obtained through systematic computer searches from major reputed scientific databases, particularly Web of Science and Scopus. Occasionally, information issued in primary sources not covered by these databases was also included provided published as peer-reviewed literature. This review covers the literature disclosed till the end of 2018.

Results: Accompanying the increasing interest in herbal medicines in general, the evaluation of the biological properties of medicinal plants from the Geranium genus has been addressed thoroughly, mostly over the last two decades. Geranium species are endowed with a number of different biological activities. Herein, we present a survey of the results of the studies concerning these different biological activities.

Conclusion: Most studies found in the literature effectively contribute to scientifically validate the beneficial properties of Geranium plants claimed by traditional medicines and medical herbalism and demonstrate that many of them possess evident therapeutic properties.

Keywords: Geranium species, medicinal plants, biological properties, species, herbalism, ailments.

« Previous Next »
[1]
WHO, IUCN, WWF. Guidelines on the conservation of medicinal plants.World Health Organization 1993.
[2]
WHO. WHO Traditional Medicine Strategy 2014-2023. Geneva: World Health Organization 2013.
[3]
Ahmad I, Aqil F, Ahmad F, Owais M. Herbal medicines: prospects and constraintsModern phytomedicine: turning medicinal plants into drugs. Weinheim: WILEY-VCH 2006; pp. 59-76.
[http://dx.doi.org/10.1002/9783527609987.ch3]
[4]
Welz AN, Emberger-Klein A, Menrad K. Why people use herbal medicine: insights from a focus-group study in Germany. BMC Complement Altern Med 2018; 18(1): 92.
[http://dx.doi.org/10.1186/s12906-018-2160-6]] [PMID: 29544493]
[5]
Graça VC, Ferreira ICFR, Santos PF. Phytochemical composition and biological activities of Geranium robertianum L.: a review. Ind Crops Prod 2016; 87: 363-78.
[http://dx.doi.org/10.1016/j.indcrop.2016.04.058]
[6]
The Plant List Available from: http://www.theplantlist.org
[7]
Fiz O, Vargas P, Alarcón M, Aedo C, García JL, Aldasoro JJ. Phylogeny and historical biogeography of Geraniaceae in relation to climate changes and pollination ecology. Syst Bot 2008; 33: 326-42.
[http://dx.doi.org/10.1600/036364408784571482]
[8]
Simpson MG. Plant Systematics. 2nd ed. Burlington: Elsevier 2010.
[http://dx.doi.org/10.1016/B978-0-12-374380-0.50001-4]
[9]
Aedo C, Garmendia FM, Pando F. World checklist of Geranium L. (Geraniaceae). Anales Jard Bot Madrid 1998; 56: 211-52.
[10]
Ávila MB, Lúcio JAG, Mendoza NV, González CV, Arciniega M, Vargas GA. Geranium species as antioxidants oxidative stress and chronic degenerative diseases - a role for antioxidants. Intech 2013; pp. 113-29.
[11]
Miller DM. The taxonomy of Geranium species and cultivars, their origins and growth in the wild Geranium and Pelargonium - The Genera Geranium and Pelargonium. London: Taylor & Francis 2002; pp. 11-9.
[12]
Williamson EM. Use of Geranium species extracts as herbal medicines Geranium and Pelargonium - The Genera Geranium and Pelargonium. London: Taylor & Francis 2002; pp. 40-6.
[13]
Ngezahayo J, Havyarimana F, Hari L, Stévigny C, Duez P. Medicinal plants used by Burundian traditional healers for the treatment of microbial diseases. J Ethnopharmacol 2015; 173: 338-51.
[http://dx.doi.org/10.1016/j.jep.2015.07.028] [PMID: 26232628]
[14]
Uzun E, Sariyar G, Adsersen A, et al. Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. J Ethnopharmacol 2004; 95(2-3): 287-96.
[http://dx.doi.org/10.1016/j.jep.2004.07.013] [PMID: 15507351]
[15]
Aranda-Ventura J, Villacrés J, Mego R, Delgado H. [Effect of extracts of Geranium ayavacense W. (Pasuchaca) on glycemia on rats with experimental diabetes mellitus]. Rev Peru Med Exp Salud Publica 2014; 31(2): 261-6.
[http://dx.doi.org/10.17843/rpmesp.2014.312.43] [PMID: 25123863]
[16]
Bautista M, Madrigal-Santillán E, Morales-González Á, et al. An alternative hepatoprotective and antioxidant agent: the Geranium. Afr J Tradit Complement Altern Med 2015; 12: 96-105.
[http://dx.doi.org/10.4314/ajtcam.v12i4.15]
[17]
Amabeoku GJ. Antidiarrhoeal activity of Geranium incanum Burm. f. (Geraniaceae) leaf aqueous extract in mice. J Ethnopharmacol 2009; 123(1): 190-3.
[http://dx.doi.org/10.1016/j.jep.2009.02.015] [PMID: 19429361]
[18]
Li J, Huang H, Feng M, Zhou W, Shi X, Zhou P. In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L. Antiviral Res 2008; 79(2): 114-20.
[http://dx.doi.org/10.1016/j.antiviral.2008.03.001] [PMID: 18423640]
[19]
Estomba D, Ladio A, Lozada M. Medicinal wild plant knowledge and gathering patterns in a Mapuche community from North-western Patagonia. J Ethnopharmacol 2006; 103(1): 109-19.
[http://dx.doi.org/10.1016/j.jep.2005.07.015] [PMID: 16157460]
[20]
Molares S, Ladio A. Chemosensory perception and medicinal plants for digestive ailments in a Mapuche community in NW Patagonia, Argentina. J Ethnopharmacol 2009; 123(3): 397-406.
[http://dx.doi.org/10.1016/j.jep.2009.03.033] [PMID: 19501272]
[21]
Rodriguez J, Loyola JI, Maulén G, Schmeda-Hirschmann G. Hypoglycaemic activity of Geranium core-core, Oxalis rosea and Plantago major extract in rats. Phytother Res 1994; 8: 372-4.
[http://dx.doi.org/10.1002/ptr.2650080613]
[22]
El Beyrouthy M, Arnold N, Delelis-Dusollier A, Dupont F. Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon. J Ethnopharmacol 2008; 120(3): 315-34.
[http://dx.doi.org/10.1016/j.jep.2008.08.024] [PMID: 18809483]
[23]
Agnihotri P, Singh H, Husain D, Dixit V. Notes on the ethnobotanically important genus Geranium Linnaeus (Geraniaceae) in India. Pleione 2014; 8: 396-407.
[24]
Tetik F, Civelek S, Cakilcioglu U. Traditional uses of some medicinal plants in Malatya (Turkey). J Ethnopharmacol 2013; 146(1): 331-46.
[http://dx.doi.org/10.1016/j.jep.2012.12.054] [PMID: 23333750]
[25]
Steenkamp V. Traditional herbal remedies used by South African women for gynaecological complaints. J Ethnopharmacol 2003; 86(1): 97-108.
[http://dx.doi.org/10.1016/S0378-8741(03)00053-9] [PMID: 12686447]
[26]
Oh J-Y, Lee K-J, Wei B, et al. Antibacterial activities of bark extracts from Fraxinus rhynchophylla Hance and Geranium koreanum Kom. against clinical strains of Clostridium perfringens in chickens. Korean J Vet Res 2015; 55: 117-23.
[http://dx.doi.org/10.14405/kjvr.2015.55.2.117]
[27]
Menendez-Baceta G, Aceituno-Mata L, Molina M, Reyes-García V, Tardío J, Pardo-de-Santayana M. Medicinal plants traditionally used in the northwest of the Basque Country (Biscay and Alava), Iberian Peninsula. J Ethnopharmacol 2014; 152(1): 113-34.
[http://dx.doi.org/10.1016/j.jep.2013.12.038] [PMID: 24389558]
[28]
Chalchat J-C, Petrovic SD, Maksimovic ZA, Gorunovic MS. A comparative study on essential oils of Geranium macrorrhizum L. and Geranium phaeum L., Geraniaceae from Serbia. J Essent Oil Res 2002; 14: 333-5.
[http://dx.doi.org/10.1080/10412905.2002.9699873]
[29]
Ivancheva S, Stantcheva B. Ethnobotanical inventory of medicinal plants in Bulgaria. J Ethnopharmacol 2000; 69(2): 165-72.
[http://dx.doi.org/10.1016/S0378-8741(99)00129-4] [PMID: 10687872]
[30]
Menković N, Savikin K, Tasić S, et al. Ethnobotanical study on traditional uses of wild medicinal plants in Prokletije Mountains (Montenegro). J Ethnopharmacol 2011; 133(1): 97-107.
[http://dx.doi.org/10.1016/j.jep.2010.09.008] [PMID: 20837123]
[31]
Redzić SS. The ecological aspect of ethnobotany and ethnopharmacology of population in Bosnia and Herzegovina. Coll Antropol 2007; 31(3): 869-90.
[PMID: 18041402]
[32]
Küpeli E, Tatli II, Akdemir ZS, Yesilada E. Estimation of antinociceptive and anti-inflammatory activity on Geranium pratense subsp. finitimum and its phenolic compounds. J Ethnopharmacol 2007; 114(2): 234-40.
[http://dx.doi.org/10.1016/j.jep.2007.08.005] [PMID: 17904777]
[33]
Ijaz F, Iqbal Z, Rahman IU, et al. Investigation of traditional medicinal floral knowledge of Sarban Hills, Abbottabad, KP, Pakistan. J Ethnopharmacol 2016; 179: 208-33.
[http://dx.doi.org/10.1016/j.jep.2015.12.050] [PMID: 26739924]
[34]
Manandhar NP. A survey of medicinal plants of Jajarkot district, Nepal. J Ethnopharmacol 1995; 48(1): 1-6.
[http://dx.doi.org/10.1016/0378-8741(95)01269-J] [PMID: 8569241]
[35]
Alanís AD, Calzada F, Cervantes JA, Torres J, Ceballos GM. Antibacterial properties of some plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol 2005; 100(1-2): 153-7.
[http://dx.doi.org/10.1016/j.jep.2005.02.022] [PMID: 16005589]
[36]
Calzada F, Cervantes-Martínez JA, Yépez-Mulia L. In vitro antiprotozoal activity from the roots of Geranium mexicanum and its constituents on Entamoeba histolytica and Giardia lamblia. J Ethnopharmacol 2005; 98(1-2): 191-3.
[http://dx.doi.org/10.1016/j.jep.2005.01.019] [PMID: 15763382]
[37]
Calzada F, Yépez-Mulia L, Tapia-Contreras A. Effect of Mexican medicinal plant used to treat trichomoniasis on Trichomonas vaginalis trophozoites. J Ethnopharmacol 2007; 113(2): 248-51.
[http://dx.doi.org/10.1016/j.jep.2007.06.001] [PMID: 17628366]
[38]
Neves JM, Matos C, Moutinho C, Queiroz G, Gomes LR. Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal). J Ethnopharmacol 2009; 124(2): 270-83.
[http://dx.doi.org/10.1016/j.jep.2009.04.041] [PMID: 19409473]
[39]
Dutt HC, Bhagat N, Pandita S. Oral traditional knowledge on medicinal plants in jeopardy among Gaddi shepherds in hills of northwestern Himalaya, J&K, India. J Ethnopharmacol 2015; 168: 337-48.
[http://dx.doi.org/10.1016/j.jep.2015.03.076] [PMID: 25862962]
[40]
Singh G, Rawat GS. Ethnomedicinal survey of Kedarnath wildlife sanctuary in Western Himalaya, India. Indian J Fund Appl Life Sci 2011; 1: 35-46.
[41]
Kosuge T, Yokota M, Sugiyama K, Yamamoto T, Ni MY, Yan SC. [Studies on antitumor activities and antitumor principles of Chinese herbs. I. Antitumor activities of Chinese herbs]. Yakugaku Zasshi 1985; 105(8): 791-5.
[http://dx.doi.org/10.1248/yakushi1947.105.8_791] [PMID: 4087154]
[42]
Weckerle CS, Ineichen R, Huber FK, Yang Y. Mao’s heritage: medicinal plant knowledge among the Bai in Shaxi, China, at a crossroads between distinct local and common widespread practice. J Ethnopharmacol 2009; 123(2): 213-28.
[http://dx.doi.org/10.1016/j.jep.2009.03.014] [PMID: 19429365]
[43]
Kayani S, Ahmad M, Sultana S, et al. Ethnobotany of medicinal plants among the communities of Alpine and Sub-alpine regions of Pakistan. J Ethnopharmacol 2015; 164: 186-202.
[http://dx.doi.org/10.1016/j.jep.2015.02.004] [PMID: 25680839]
[44]
Khan SM, Page S, Ahmad H, et al. Medicinal flora and ethnoecological knowledge in the Naran Valley, Western Himalaya, Pakistan. J Ethnobiol Ethnomed 2013; 9: 4.
[http://dx.doi.org/10.1186/1746-4269-9-4] [PMID: 23302393]
[45]
Malla B, Gauchan DP, Chhetri RB. An ethnobotanical study of medicinal plants used by ethnic people in Parbat district of western Nepal. J Ethnopharmacol 2015; 165: 103-17.
[http://dx.doi.org/10.1016/j.jep.2014.12.057] [PMID: 25571849]
[46]
Alonso-Castro AJ, Villarreal ML, Salazar-Olivo LA, Gomez-Sanchez M, Dominguez F, Garcia-Carranca A. Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and ethnobotanical studies. J Ethnopharmacol 2011; 133(3): 945-72.
[http://dx.doi.org/10.1016/j.jep.2010.11.055] [PMID: 21146599]
[47]
Calzada F, Meckes M, Cedillo-Rivera R, Tapia-Contreras A, Mata R. Screening of Mexican medicinal plants for antiprotozoal activity. Pharm Biol 1998; 36: 305-9.
[http://dx.doi.org/10.1076/phbi.36.5.305.4653]
[48]
Maldonado PD, Rivero-Cruz I, Mata R, Pedraza-Chaverrí J. Antioxidant activity of A-type proanthocyanidins from Geranium niveum (Geraniaceae). J Agric Food Chem 2005; 53(6): 1996-2001.
[http://dx.doi.org/10.1021/jf0483725] [PMID: 15769126]
[49]
Tapia-Pérez ME, Tapia-Contreras A, Cedillo-Rivera R, Osuna L, Meckes M. Screening of Mexican medicinal plants for antiprotozoal activity – Part II. Pharm Biol 2003; 41: 180-3.
[http://dx.doi.org/10.1076/phbi.41.3.180.15100]
[50]
Chang SW, Kim KH, Lee IK, Choi SU, Lee KR. Phytochemical constituents of Geranium eriostemon. Nat Prod Sci 2009; 15: 151-5.
[51]
Mantle D, Eddeb F, Pickering AT. Comparison of relative antioxidant activities of British medicinal plant species in vitro. J Ethnopharmacol 2000; 72(1-2): 47-51.
[http://dx.doi.org/10.1016/S0378-8741(00)00199-9] [PMID: 10967453]
[52]
Angmo K, Adhikari BS, Rawat GS. Changing aspects of traditional healthcare system in western Ladakh, India. J Ethnopharmacol 2012; 143(2): 621-30.
[http://dx.doi.org/10.1016/j.jep.2012.07.017] [PMID: 22884871]
[53]
Ballabh B, Chaurasia OP. Traditional medicinal plants of cold desert Ladakh--used in treatment of cold, cough and fever. J Ethnopharmacol 2007; 112(2): 341-9.
[http://dx.doi.org/10.1016/j.jep.2007.03.020] [PMID: 17459623]
[54]
Singh KN, Lal B. Ethnomedicines used against four common ailments by the tribal communities of Lahaul-Spiti in western Himalaya. J Ethnopharmacol 2008; 115(1): 147-59.
[http://dx.doi.org/10.1016/j.jep.2007.09.017] [PMID: 17980527]
[55]
Camejo-Rodrigues J, Ascensão L, Bonet MÀ, Vallès J. An ethnobotanical study of medicinal and aromatic plants in the Natural Park of “Serra de São Mamede” (Portugal). J Ethnopharmacol 2003; 89(2-3): 199-209.
[http://dx.doi.org/10.1016/S0378-8741(03)00270-8] [PMID: 14611883]
[56]
Novais MH, Santos I, Mendes S, Pinto-Gomes C. Studies on pharmaceutical ethnobotany in Arrabida Natural Park (Portugal). J Ethnopharmacol 2004; 93(2-3): 183-95.
[http://dx.doi.org/10.1016/j.jep.2004.02.015] [PMID: 15234752]
[57]
Guarrera PM. Traditional antihelmintic, antiparasitic and repellent uses of plants in Central Italy. J Ethnopharmacol 1999; 68(1-3): 183-92.
[http://dx.doi.org/10.1016/S0378-8741(99)00089-6] [PMID: 10624877]
[58]
Loi MC, Poli F, Sacchetti G, Selenu MB, Ballero M. Ethnopharmacology of ogliastra (villagrande strisaili, sardinia, Italy). Fitoterapia 2004; 75(3-4): 277-95.
[http://dx.doi.org/10.1016/j.fitote.2004.01.008] [PMID: 15158984]
[59]
Menale B, Muoio R. Use of medicinal plants in the South-Eastern area of the Partenio Regional Park (Campania, Southern Italy). J Ethnopharmacol 2014; 153(1): 297-307.
[http://dx.doi.org/10.1016/j.jep.2014.02.039] [PMID: 24583106]
[60]
Vitalini S, Puricelli C, Mikerezi I, Iriti M. Plants, people and traditions: ethnobotanical survey in the Lombard Stelvio National Park and neighbouring areas (Central Alps, Italy). J Ethnopharmacol 2015; 173: 435-58.
[http://dx.doi.org/10.1016/j.jep.2015.05.036] [PMID: 26031473]
[61]
Akerreta S, Calvo MI, Cavero RY. Ethnoveterinary knowledge in Navarra (Iberian Peninsula). J Ethnopharmacol 2010; 130(2): 369-78.
[http://dx.doi.org/10.1016/j.jep.2010.05.023] [PMID: 20573568]
[62]
Rigat M, Vallès J, Iglésias J, Garnatje T. Traditional and alternative natural therapeutic products used in the treatment of respiratory tract infectious diseases in the eastern Catalan Pyrenees (Iberian Peninsula). J Ethnopharmacol 2013; 148(2): 411-22.
[http://dx.doi.org/10.1016/j.jep.2013.04.022] [PMID: 23612419]
[63]
Rigat M, Vallès J, D’Ambrosio U, Gras A, Iglésias J, Garnatje T. Plants with topical uses in the Ripollès district (Pyrenees, Catalonia, Iberian Peninsula): ethnobotanical survey and pharmacological validation in the literature. J Ethnopharmacol 2015; 164: 162-79.
[http://dx.doi.org/10.1016/j.jep.2015.01.055] [PMID: 25666424]
[64]
Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. J Ethnopharmacol 2002; 83(3): 251-65.
[http://dx.doi.org/10.1016/S0378-8741(02)00253-2] [PMID: 12426094]
[65]
Cunha AP, Silva AP, Roque AR. Plantas e produtos vegetais em fitoterapia. 4th ed. Lisboa: Fundação Calouste Gulbenkian 2012.
[66]
Rivera D, Obón C. The ethnopharmacology of Madeira and Porto Santo Islands, a review. J Ethnopharmacol 1995; 46(2): 73-93.
[http://dx.doi.org/10.1016/0378-8741(95)01239-A] [PMID: 7650952]
[67]
Jarić S, Popović Z, Macukanović-Jocić M, et al. An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia). J Ethnopharmacol 2007; 111(1): 160-75.
[http://dx.doi.org/10.1016/j.jep.2006.11.007] [PMID: 17145148]
[68]
Sharma A, Flores-Vallejo RDC, Cardoso-Taketa A, Villarreal ML. Antibacterial activities of medicinal plants used in Mexican traditional medicine. J Ethnopharmacol 2017; 208: 264-329.
[http://dx.doi.org/10.1016/j.jep.2016.04.045] [PMID: 27155134]
[69]
Bnouham M, Mekhfi H, Legssyer A, Ziyyat A. Medicinal plants used in the treatment of diabetes in Morocco. Int J Diabetes Metab 2002; 10: 33-50.
[70]
Mosaddegh M, Naghibi F, Moazzeni H, Pirani A, Esmaeili S. Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J Ethnopharmacol 2012; 141(1): 80-95.
[http://dx.doi.org/10.1016/j.jep.2012.02.004] [PMID: 22366675]
[71]
Sher H, Bussmann RW, Hart R, de Boer HJ. Traditional use of medicinal plants among Kalasha, Ismaeli and Sunni groups in Chitral District, Khyber Pakhtunkhwa province, Pakistan. J Ethnopharmacol 2016; 188: 57-69.
[http://dx.doi.org/10.1016/j.jep.2016.04.059] [PMID: 27154408]
[72]
Viegi L, Pieroni A, Guarrera PM, Vangelisti R. A review of plants used in folk veterinary medicine in Italy as basis for a databank. J Ethnopharmacol 2003; 89(2-3): 221-44.
[http://dx.doi.org/10.1016/j.jep.2003.08.003] [PMID: 14611886]
[73]
Ikeda T, Tanaka Y, Yamamoto K, Morii H, Kamisako T, Ogawa H. Geranium dielsianum extract poder (MISKAMISKATM) improves the intestinal environment through alteration of microbiota and microbial metabolites in rats. J Funct Foods 2014; 11: 12-9.
[http://dx.doi.org/10.1016/j.jff.2014.08.018]
[74]
Leporatti ML, Ivancheva S. Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy. J Ethnopharmacol 2003; 87(2-3): 123-42.
[http://dx.doi.org/10.1016/S0378-8741(03)00047-3] [PMID: 12860298]
[75]
Serkedjieva J, Ivancheva S. Antiherpes virus activity of extracts from the medicinal plant Geranium sanguineum L. J Ethnopharmacol 1999; 64(1): 59-68.
[http://dx.doi.org/10.1016/S0378-8741(98)00095-6] [PMID: 10075123]
[76]
Gayosso-De-Lucio J, Bautista M, Velazquez-González C, De la O Arciniega M, Morales-González JA, Benedí J. Chemical composition and hepatotoxic effect of Geranium schiedeanum in a thioacetamide-induced liver injury model. Pharmacogn Mag 2014; 10(Suppl. 3): S574-80.
[http://dx.doi.org/10.4103/0973-1296.139788] [PMID: 25298677]
[77]
Alonso-Castro AJ, Domínguez F, Zapata-Morales JR, Carranza-Álvarez C. Plants used in the traditional medicine of Mesoamerica (Mexico and Central America) and the Caribbean for the treatment of obesity. J Ethnopharmacol 2015; 175: 335-45.
[http://dx.doi.org/10.1016/j.jep.2015.09.029] [PMID: 26410815]
[78]
Hammond GB, Fernández ID, Villegas LF, Vaisberg AJ. A survey of traditional medicinal plants from the Callejón de Huaylas, Department of Ancash, Perú. J Ethnopharmacol 1998; 61(1): 17-30.
[http://dx.doi.org/10.1016/S0378-8741(98)00009-9] [PMID: 9687078]
[79]
Shim J-U, Oh P-S, Lim K-T. Anti-inflammatory activity of ethanol extract from Geranium sibiricum Linne. J Ethnopharmacol 2009; 126(1): 90-5.
[http://dx.doi.org/10.1016/j.jep.2009.08.004] [PMID: 19683044]
[80]
Zuo GY, Wang GC, Zhao YB, et al. Screening of Chinese medicinal plants for inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). J Ethnopharmacol 2008; 120(2): 287-90.
[http://dx.doi.org/10.1016/j.jep.2008.08.021] [PMID: 18804522]
[81]
Nakanishi Y, Orita M, Okuda T, Abe H. Effects of geraniin on the liver in rats I- effects of geraniin compared to ellagic acid, and gallic acid on hepatic injuries induced by CC14, D-galactosamine, and thioacetamide. Natural Medicines 1998; 52: 396-403.
[82]
Okuda T, Yoshida T, Hatano T. Constituents of Geranium thunbergii Sieb. et Zucc. Part 12. Hydrated stereostructure and equilibration of geraniin. J Chem Soc Perkin Trans 1982; 1: 9-14.
[http://dx.doi.org/10.1039/p19820000009]
[83]
Ballabh B, Chaurasia OP, Ahmed Z, Singh SB. Traditional medicinal plants of cold desert Ladakh-used against kidney and urinary disorders. J Ethnopharmacol 2008; 118(2): 331-9.
[http://dx.doi.org/10.1016/j.jep.2008.04.022] [PMID: 18550306]
[84]
González-Tejero MR, Casares-Porcel M, Sánchez-Rojas CP, et al. Medicinal plants in the Mediterranean area: synthesis of the results of the project Rubia. J Ethnopharmacol 2008; 116(2): 341-57.
[http://dx.doi.org/10.1016/j.jep.2007.11.045] [PMID: 18242025]
[85]
Baydoun S, Chalak L, Dalleh H, Arnold N. Ethnopharmacological survey of medicinal plants used in traditional medicine by the communities of Mount Hermon, Lebanon. J Ethnopharmacol 2015; 173: 139-56.
[http://dx.doi.org/10.1016/j.jep.2015.06.052] [PMID: 26165826]
[86]
Kumar K, Sharma YP, Manhas RK, Bhatia H. Ethnomedicinal plants of Shankaracharya Hill, Srinagar, J&K, India. J Ethnopharmacol 2015; 170: 255-74.
[http://dx.doi.org/10.1016/j.jep.2015.05.021] [PMID: 26008867]
[87]
Shaheen H, Shinwari ZK, Qureshi RA, Ullah Z. Indigenous plant resources and their utilization practices in village populations of Kashmir Himalayas. Pak J Bot 2012; 44: 739-45.
[88]
Thakur M, Asrani RK, Thakur S, et al. Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India. J Ethnopharmacol 2016; 191: 280-300.
[http://dx.doi.org/10.1016/j.jep.2016.06.033] [PMID: 27321279]
[89]
Mahmood A, Mahmood A, Malik RN. Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan. J Ethnopharmacol 2012; 143(1): 338-46.
[http://dx.doi.org/10.1016/j.jep.2012.06.046] [PMID: 22789966]
[90]
Saqib Z, Mahmood A, Naseem Malik R, Mahmood A, Hussian Syed J, Ahmad T. Indigenous knowledge of medicinal plants in Kotli Sattian, Rawalpindi district, Pakistan. J Ethnopharmacol 2014; 151(2): 820-8.
[http://dx.doi.org/10.1016/j.jep.2013.11.034] [PMID: 24286963]
[91]
Rokaya MB, Münzbergová Z, Timsina B. Ethnobotanical study of medicinal plants from the Humla district of western Nepal. J Ethnopharmacol 2010; 130(3): 485-504.
[http://dx.doi.org/10.1016/j.jep.2010.05.036] [PMID: 20553834]
[92]
Zhang X-Q, Gu H-M, Li X-Z, Xu Z-N, Chen Y-S, Li Y. Anti-Helicobacter pylori compounds from the ethanol extracts of Geranium wilfordii. J Ethnopharmacol 2013; 147(1): 204-7.
[http://dx.doi.org/10.1016/j.jep.2013.02.032] [PMID: 23500884]
[93]
Acharya J, Hildreth MB, Reese RN. In vitro screening of forty medicinal plant extracts from the United States Northern Great Plains for anthelmintic activity against Haemonchus contortus. Vet Parasitol 2014; 201(1-2): 75-81.
[http://dx.doi.org/10.1016/j.vetpar.2014.01.008] [PMID: 24548703]
[94]
Preston SJM, Sandeman M, Gonzalez J, Piedrafita D. Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going? J Immunol Res 2014; 2014210350
[http://dx.doi.org/10.1155/2014/210350] [PMID: 25258718]
[95]
Olalekan BJ, Robert GI, Thozamile MW. The anthelmintic and antioxidant activities of South African Geranium Incanum. Int J Med Plants Nat Prod 2015; 1: 35-43.
[96]
Tosun F, Kızılay ÇA, Şener B, Vural M. The evaluation of plants from Turkey for in vitro antimycobacterial activity. Pharm Biol 2005; 43: 58-63.
[http://dx.doi.org/10.1080/13880200590903372]
[97]
Ooshiro A, Natsume M. Control of potato scab by Geranium carolinianum L. Weed Biol Manage 2007; 7: 124-7.
[http://dx.doi.org/10.1111/j.1445-6664.2007.00245.x]
[98]
Ooshiro A, Takaesu K, Natsume M, et al. Identification and use of a wild plant with antimicrobial activity against Ralstonia solanacearum, the cause of bacterial wilt of potato. Weed Biol Manage 2004; 4: 187-94.
[http://dx.doi.org/10.1111/j.1445-6664.2004.00137.x]
[99]
Şöhretoğlu D, Sakar MK, Erizoğlu M, Özalp M. Free radical scavenging and antimicrobial activities of three Geranium species growing in Turkey. FABAD J Pharm Sci 2007; 32: 59-63.
[100]
Babajide OJ, Mabusela WT, Green IR, Ameer F, Weitz F, Iwuoha EI. Phytochemical screening and biological activity studies of five South African indigenous medicinal plants. J Med Plants Res 2010; 2: 1924-32.
[101]
Scott G, Springfield EP, Coldrey N. A pharmacognostical study of 26 South African plant species used as traditional medicines. Pharm Biol 2004; 42: 186-213.
[http://dx.doi.org/10.1080/13880200490514032]
[102]
Şöhretoğlu D, Erizoğlu M, Özalp M, Sakar MK. Free radical scavenging and antimicrobial activities of some Geranium species. Hacettepe Univ J Fac Pharm 2008; 28: 115-24.
[103]
Ivancheva S, Manolova N, Serkedjieva J, Dimov V, Ivanovska N. Polyphenols from Bulgarian medicinal plants with anti-infectious activityPlant Polyphenols: Synthesis, Properties, Significance. New York: Plenum Press 1992; pp. 717-28.
[http://dx.doi.org/10.1007/978-1-4615-3476-1_43]
[104]
Radulović NS, Stojković MB, Mitić SS, et al. Exploitation of the antioxidant potential of Geranium macrorrhizum (Geraniaceae): hepatoprotective and antimicrobial activities. Nat Prod Commun 2012; 7(12): 1609-14.
[http://dx.doi.org/10.1177/1934578X1200701218] [PMID: 23413565]
[105]
Nastić N, Švarc-Gajić J, Delerue-Matos C, et al. Subcritical water extraction as an environmentally-friendly technique to recover bioactive compounds from traditional Serbian medicinal plants. Ind Crops Prod 2018; 111: 579-89.
[http://dx.doi.org/10.1016/j.indcrop.2017.11.015]
[106]
Ushiki J, Hayakawa Y, Tadano T. Medicinal plants for suppressing soil-borne plant diseases. Soil Sci Plant Nutr 1996; 42: 423-6.
[107]
Ushiki J, Tahara S, Hayakawa Y, Tadano T. Medicinal plants for suppressing soil-borne plant diseases. Soil Sci Plant Nutr 1998; 44: 157-65.
[http://dx.doi.org/10.1080/00380768.1998.10414436]
[108]
Nunes R, Pasko P, Tyszka-Czochara M, Szewczyk A, Szlosarczyk M, Carvalho IS. Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs. Pharm Biol 2017; 55(1): 114-23.
[http://dx.doi.org/10.1080/13880209.2016.1230636] [PMID: 27925492]
[109]
Proestos C, Boziaris IS, Nychas G-JE, Komaitis M. Analysis of flavonoids and phenolic acids in Greek aromatic plants: Investigation of their antioxidant capacity and antimicrobial activity. Food Chem 2006; 95: 664-71.
[http://dx.doi.org/10.1016/j.foodchem.2005.01.049]
[110]
Ertürk Ö. Antibacterial and antifungal effects of Geranium purpureum Vill. (Geraniaceae) extracts. Fresenius Environ Bull 2010; 19: 3112-7.
[111]
Ӧzçelik B, Özgen S, Öztürk S, Küsmenoğlu Ş. Evaluation of antibacterial and antifungal activities of Geranium pyrenaicum L. Turk J Pharm Sci 2010; 7: 111-7.
[112]
Shawarb N, Jaradat N, Abu-Qauod H, Alkowni R, Hussein F. Investigation of antibacterial & antioxidant activity for methanolic extract from different edible plant species in Palestine. Mor J Chem 2017; 5: 573-9.
[113]
Benzel IL, Hordiienko OI, Hroshovyi TA, Benzel LV, Pokryshko OV. Obtaining of Geranium sanguineum phytoextracts and study of their antimicrobial properties. Int J Green Pharm 2018; 12: 142-7.
[114]
Choi H-A, Cheong D-E, Lim H-D, et al. Antimicrobial and anti-biofilm activities of the methanol extracts of medicinal plants against dental pathogens Streptococcus mutans and Candida albicans. J Microbiol Biotechnol 2017; 27(7): 1242-8.
[http://dx.doi.org/10.4014/jmb.1701.01026] [PMID: 28478657]
[115]
Lee SH, Kang KM, Park HJ, Baek LM. Physiological characteristics of medicinal plant extracts for use as functional materials in seasoning sauce for pork meat. Korean J Food Sci Technol 2009; 41: 100-5.
[116]
Kwon T-H, Lee S-J, Park J-H, Kim T, Park J-J, Park N-H. Antimicrobial activity and protective effect of Geranium thunbergii against oxidative DNA damage via antioxidant effect. Korean J Food Preserv 2017; 24: 325-33.
[http://dx.doi.org/10.11002/kjfp.2017.24.3.325]
[117]
Ismail M, Hussain J, Khan AU, et al. Antibacterial, antifungal, cytotoxic, phytotoxic, insecticidal, and enzyme inhibitory activities of Geranium wallichianum. Evid Based Complement Alternat Med 2012; 2012305906
[http://dx.doi.org/10.1155/2012/305906]] [PMID: 23049606]
[118]
Renda G, Celik G, Korkmaz B, Karaoglum SA, Yayli N. Antimicrobial activity and analyses of six Geranium L. species with headspace SPME and hydrodistillation. J Essent Oil Bear Pl 2016; 19: 2003-16.
[http://dx.doi.org/10.1080/0972060X.2016.1235995]
[119]
Radulović N, Dekić M, Radić ZS, Palić R. Chemical composition and antimicrobial activity of the essential oils of Geranium columbinum L. and G. lucidum L. (Geraniaceae). Turk J Chem 2011; 35: 499-512.
[120]
Radulović NS, Dekić MS, Stojanović-Radić ZZ, Zoranić SK. Geranium macrorrhizum L. (Geraniaceae) essential oil: a potent agent against Bacillus subtilis. Chem Biodivers 2010; 7(11): 2783-800.
[http://dx.doi.org/10.1002/cbdv.201000100] [PMID: 21072778]
[121]
Gębarowska E, Politowicz J, Szumny A. Chemical composition and antimicrobial activity of Geranium robertianum L. essential oil. Acta Pol Pharm 2017; 74(2): 699-705.
[PMID: 29624276]
[122]
Radulović N, Dekic M, Stojanovic-Radic Z. Chemical composition and antimicrobial activity of the volatile oils of Geranium sanguineum L. and G. robertianum L. (Geraniaceae). Med Chem Res 2012; 21: 601-15.
[http://dx.doi.org/10.1007/s00044-011-9565-9]
[123]
Kashiwada Y, Nonaka G, Nishioka I, Chang J-J, Lee K-H. Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents. J Nat Prod 1992; 55(8): 1033-43.
[http://dx.doi.org/10.1021/np50086a002] [PMID: 1431932]
[124]
Mazzio E, Badisa R, Mack N, Deiab S, Soliman KFA. High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells. Phytother Res 2014; 28(6): 856-67.
[http://dx.doi.org/10.1002/ptr.5065] [PMID: 24105850]
[125]
Mazzio EA, Soliman KFA. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res 2009; 23(3): 385-98.
[http://dx.doi.org/10.1002/ptr.2636] [PMID: 18844256]
[126]
Kim H-S. The Anti-melanogenic effect of Geranium krameri extract. Korean J Food Sci Technol 2016; 48: 72-6.
[http://dx.doi.org/10.9721/KJFST.2016.48.1.72]
[127]
Graça VC, Barros L, Calhelha RC, et al. Chemical characterization and bioactive properties of aqueous and organic extracts of Geranium robertianum L. Food Funct 2016; 7(9): 3807-14.
[http://dx.doi.org/10.1039/C6FO01075J] [PMID: 27603422]
[128]
Graça VC, Barros L, Calhelha RC, et al. Chemical characterization and bioactive properties of Geranium molle L.: from the plant to the most active extract and its phytochemicals. Food Funct 2016; 7(5): 2204-12.
[http://dx.doi.org/10.1039/C5FO01479D] [PMID: 27094513]
[129]
Graça VC, Barros L, Calhelha RC, Dias MI, Ferreira ICFR, Santos PF. Bio-guided fractionation of extracts of Geranium robertianum L.: Relationship between phenolic profile and biological activity. Ind Crops Prod 2017; 108: 543-52.
[http://dx.doi.org/10.1016/j.indcrop.2017.07.016]
[130]
Graça VC, Dias MI, Barros L, Calhelha RC, Santos PF, Ferreira ICFR. Fractionation of the more active extracts of Geranium molle L.: a relationship between their phenolic profile and biological activity. Food Funct 2018; 9(4): 2032-42.
[http://dx.doi.org/10.1039/C7FO01994G] [PMID: 29541715]
[131]
Şöhretoğlu D, Genç Y, Harput Ş. Comparative evaluation of phenolic profile, antioxidative and cytotoxic activities of different Geranium species. Iran J Pharm Res 2017; 16(Suppl.): 178-87.
[PMID: 29844789]
[132]
Venskutonis PR, Dedonytė V, Lazutka J, et al. A preliminary assessment of singlet oxygen scavenging, cytotoxic and genotoxic properties of Geranium macrorrhizum extracts. Acta Biochim Pol 2010; 57(2): 157-63.
[http://dx.doi.org/10.18388/abp.2010_2389] [PMID: 20454706]
[133]
Sharopov FS, Sobeh M, Satyal P, Setzer WN, Wink M. Antioxidant activity and cytotoxicity of methanol extracts of Geranium macrorrhizum and chemical composition of its essential oil. J Med Active Plants 2016; 5: 53-8.
[134]
Herrera-Calderon O, Alvarado-Puray C, Arroyo-Acevedo JL, et al. Phytochemical screening, total phenolic content, antioxidant, and cytotoxic activity of five peruvian plants on human tumor cell lines. Pharmacogn Res 208(10): 161-5.
[http://dx.doi.org/10.4103/pr.pr_109_17]
[135]
Field M. Intestinal ion transport and the pathophysiology of diarrhea. J Clin Invest 2003; 111(7): 931-43.
[http://dx.doi.org/10.1172/JCI200318326] [PMID: 12671039]
[136]
Velázquez C, Calzada F, Torres J, González F, Ceballos G. Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico. J Ethnopharmacol 2006; 103(1): 66-70.
[http://dx.doi.org/10.1016/j.jep.2005.06.046] [PMID: 16174555]
[137]
Calzada F, Arista R, Pérez H. Effect of plants used in Mexico to treat gastrointestinal disorders on charcoal-gum acacia-induced hyperperistalsis in rats. J Ethnopharmacol 2010; 128(1): 49-51.
[http://dx.doi.org/10.1016/j.jep.2009.12.022] [PMID: 20035855]
[138]
George M, Joseph L. Antipyretic and antidiarrheal activity of Geranium ocellatum leaves extract. World Res J Med Aromat Plant 2012; 1: 27-9.
[139]
Kobaisy M, Tellez MR, Schrader KK, et al. Phytotoxic, antialgal, and antifungal activity of constituents from selected plants of Kazakhstan Natural products for pest management. Washington, D.C.: American Chemical Society 2006; pp. 142-51.
[http://dx.doi.org/10.1021/bk-2006-0927.ch011]
[140]
Pawar VC, Thaker VS. In vitro efficacy of 75 essential oils against Aspergillus niger. Mycoses 2006; 49(4): 316-23.
[http://dx.doi.org/10.1111/j.1439-0507.2006.01241.x] [PMID: 16784447]
[141]
Mona MMR, Ashour AMA, Abdel-Kader MM, El-Mougy NS, Abdel-Aziz A. Fungicidal and fungistatic activity of some plant essential oils against Alternaria solani the causal of tomato early blight. Res J Pharm Biol Chem Sci 2016; 7: 998-1004.
[142]
Abdel-Kader MM, El-Mougy NS, Lashin SM. Essential oils and Trichoderma harzianum as an integrated control measure against faba bean root rot pathogens. J Plant Prot Res 2011; 51: 306-13.
[http://dx.doi.org/10.2478/v10045-011-0050-8]
[143]
Uribarri J, del Castillo MD, de la Maza MP, et al. Dietary advanced glycation end products and their role in health and disease. Adv Nutr 2015; 6(4): 461-73.
[http://dx.doi.org/10.3945/an.115.008433] [PMID: 26178030]
[144]
Zia-ur-rehman M, Mirajab K, Mushtaq A. Potential for Pakistani traditional medicinal plants to combat diabetes. J Tradit Chin Med 2014; 34(4): 488-90.
[http://dx.doi.org/10.1016/S0254-6272(15)30051-0] [PMID: 25185369]
[145]
Madrigal-Santillán E, Bautista M, Gayosso-De-Lucio JA, et al. Hepatoprotective effect of Geranium schiedeanum against ethanol toxicity during liver regeneration. World J Gastroenterol 2015; 21(25): 7718-29.
[http://dx.doi.org/10.3748/wjg.v21.i25.7718] [PMID: 26167072]
[146]
Vargas-Mendoza N, Vázquez-Velasco M, González-Torres L, et al. Effect of extract and ellagic acid from Geranium schiedeanum on the antioxidant defense system in an induced-necrosis model. Antioxidants 2018; 7(12): 178.
[http://dx.doi.org/10.3390/antiox7120178] [PMID: 30513625]
[147]
Akanda MdR, Kim IS, Ahn D, et al. In vivo and in vitro hepatoprotective effects of Geranium koreanum methanolic extract via downregulation of MAPK/Caspase-3 pathway. Evid Based Complement Alternat Med 2017; 20178137627
[148]
Herrera-Calderon O, Chinchay-Salazar R, Palomino-Ormeño E, Arango-Valencia E, Arroyo J. Hypoglycemic effect of Geranium ruizii Hieron. (pasuchaca) ethanolic extract on alloxan-induced hyperglycemia in rats. An Fac Med (Lima, Peru) 2015; 76: 117-22.
[http://dx.doi.org/10.15381/anales.v76i2.11135]
[149]
Karato M, Yamaguchi K, Takei S, Kino T, Yazawa K. Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on α-glucosidase in mouse. Biosci Biotechnol Biochem 2006; 70(6): 1482-4.
[http://dx.doi.org/10.1271/bbb.50420] [PMID: 16794329]
[150]
Choi SJ, Kim JK, Jang JM, Shin KH, Lim SS. Rapid identification of the α-glucosidase inhibitory compounds from Thunberg’s Geranium (Geranium thunbergii Sieb. et Zucc.). Food Sci Biotechnol 2012; 21: 987-96.
[http://dx.doi.org/10.1007/s10068-012-0129-7]
[151]
Thilagam E, Parimaladevi B, Kumarappan C, Mandal SC. α-Glucosidase and α-amylase inhibitory activity of Senna surattensis. J Acupunct Meridian Stud 2013; 6(1): 24-30.
[http://dx.doi.org/10.1016/j.jams.2012.10.005] [PMID: 23433052]
[152]
Numonov S, Edirs S, Bobakulov K, et al. Evaluation of the antidiabetic activity and chemical composition of Geranium collinum root extracts - Computational and experimental investigations. Molecules 2017; 22(6): 983.
[http://dx.doi.org/10.3390/molecules22060983] [PMID: 28608836]
[153]
He RJ, Yu ZH, Zhang RY, Zhang ZY. Protein tyrosine phosphatases as potential therapeutic targets. Acta Pharmacol Sin 2014; 35(10): 1227-46.
[http://dx.doi.org/10.1038/aps.2014.80] [PMID: 25220640]
[154]
Renda G, Sari S, Barut B, et al. α-Glucosidase inhibitory effects of polyphenols from Geranium asphodeloides: Inhibition kinetics and mechanistic insights through in vitro and in silico studies. Bioorg Chem 2018; 81: 545-52.
[http://dx.doi.org/10.1016/j.bioorg.2018.09.009] [PMID: 30245236]
[155]
Petkov V. Plants and hypotensive, antiatheromatous and coronarodilatating action. Am J Chin Med 1979; 7(3): 197-236.
[http://dx.doi.org/10.1142/S0192415X79000180] [PMID: 574353]
[156]
Ivanov SA, Garbuz SA, Malfanov IL, Ptitsyn LR. Screening of Russian medicinal and edible plant extracts for angiotensin I-converting enzyme (ACE I) inhibitory activity. Russ J Bioorganic Chem 2013; 2: 165-72.
[http://dx.doi.org/10.1134/S1068162013070054]
[157]
Hansen K, Nyman U, Smitt UW, et al. In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE). J Ethnopharmacol 1995; 48(1): 43-51.
[http://dx.doi.org/10.1016/0378-8741(95)01286-M] [PMID: 8569246]
[158]
Huang M, Yao P-W, Chang MD-T, et al. Identification of anti-inflammatory fractions of Geranium wilfordii using tumor necrosis factor-alpha as a drug target on Herbochip® - an array-based high throughput screening platform. BMC Complement Altern Med 2015; 15: 146.
[http://dx.doi.org/10.1186/s12906-015-0665-9] [PMID: 25963543]
[159]
Choi H-J, Choi H-J, Park M-J, et al. The inhibitory effects of Geranium thunbergii on interferon-γ- and LPS-induced inflammatory responses are mediated by Nrf2 activation. Int J Mol Med 2015; 35(5): 1237-45.
[http://dx.doi.org/10.3892/ijmm.2015.2128] [PMID: 25761198]
[160]
Kwon T-H, Lee S-J, Kim Y-J, Park J-J, Kim T, Park N-H. Anti-inflammatory effect of Geranium thunbergii on lipopolysaccharide-stimulated RAW 264.7 cells. Korean J Food Sci Technol 2016; 48: 618-21.
[http://dx.doi.org/10.9721/KJFST.2016.48.6.618]
[161]
Sung H-M, Seo Y-S, Yang EJ. Anti-oxidant and anti-inflammatory activities of hot water extract obtained from Geranium thunbergii using different extraction temperatures and times. Korean Soc Food Sci Nutr 2018; 47: 1006-13.
[http://dx.doi.org/10.3746/jkfn.2018.47.10.1006]
[162]
Velázquez-González C, Cariño-Cortés R, Gayosso de Lucio JA, et al. Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds. BMC Complement Altern Med 2014; 14: 506.
[http://dx.doi.org/10.1186/1472-6882-14-506] [PMID: 25518981]
[163]
Lu CH, Li YY, Li LJ, Liang LY, Shen YM. Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols. Drug Discov Ther 2012; 6(4): 194-7.
[http://dx.doi.org/10.5582/ddt.2012.v6.4.194] [PMID: 23006989]
[164]
Piwowarski JP, Granica S, Zwierzyńska M, et al. Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. J Ethnopharmacol 2014; 155(1): 801-9.
[http://dx.doi.org/10.1016/j.jep.2014.06.032] [PMID: 24969824]
[165]
Li Y, Ye Y, Wang S-J, et al. Analgesic, anti-inflammatory and antipyretic activities of the aqueous extract of Geranium carolinianum L. Afr J Tradit Complement Altern Med 2016; 13: 105-13.
[http://dx.doi.org/10.4314/ajtcam.v13i1.15]
[166]
Catarino MD, Silva AMS, Cruz MT, Cardoso SM. Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions. Food Funct 2017; 8(9): 3355-65.
[http://dx.doi.org/10.1039/C7FO00881C] [PMID: 28858365]
[167]
Hernández-Guerrero VG, Meléndez-Camargo ME, Márquez-Flores YK, Arreguín-Sánchez ML. Estudio etnobotánico y evaluación de la actividad antiinflamatoria de Geranium seemannii Peyr. (municipio de Ozumba, estado de México). Polibotánica 2018; 46: 103-19.
[168]
Nam HH, Nan L, Choo BK. Dichloromethane extracts of Geranium koreanum Kom. alleviates esophagus damage in acute reflux esophagitis-induced rats by anti-inflammatory activities. Int J Mol Sci 2018; 19(11): 3622.
[http://dx.doi.org/10.3390/ijms19113622] [PMID: 30453554]
[169]
Roh C, Jung U. Screening of crude plant extracts with anti-obesity activity. Int J Mol Sci 2012; 13(2): 1710-9.
[http://dx.doi.org/10.3390/ijms13021710] [PMID: 22408418]
[170]
Sung Y-Y, Yoon T, Yang W-K, Kim SJ, Kim HK. Anti-obesity effects of Geranium thunbergii extract via improvement of lipid metabolism in high-fat diet-induced obese mice. Mol Med Rep 2011; 4(6): 1107-13.
[PMID: 21874243]
[171]
Kim S-G, Lamichhane R, Sharma DK, Lee K-H, Choi J, Jung H-J. Anti-obesity and anti-hyperlipidemic effects of butanol soluble fraction from methanol extract of Geranium thunbergii in Sprague-Dawley rats. Korean J Pharmacogn 2014; 45: 69-76.
[172]
Okuhama N, Babar S, Melchor V, Miller MJS, Sandoval M. Antioxidant and anti-inflammatory activities of Geranium ayavacense: role in oxidative stress. Free Radic Biol Med 2002; 33(Suppl. 2): S337.
[173]
Camacho-Luis A, Gayosso-De-Lucio JA, Torres-Valencia JM, et al. Antioxidant constituents of Geranium bellum Rose. J Mex Chem Soc 2008; 52: 103-7.
[174]
Nikolova M, Tsvetkova R, Ivancheva S. Evaluation of antioxidant activity in some Geraniaceae species. Bot Serb 2010; 34: 123-5.
[175]
Sapko OA, Chebonenko OV, Utarbaeva ASh, Amirkulova AZh, Tursunova AK. Antioxidant activity of medicinal plants from Southeastern Kazakhstan. Pharm Chem J 2016; 50: 33-7.
[http://dx.doi.org/10.1007/s11094-016-1499-6]
[176]
Adam M, Elhassan GOM, Yagi S, et al. In vitro antioxidant and cytotoxic activities of 18 plants from the Erkowit Region, Eastern Sudan. Nat Prod Bioprospect 2018; 8(2): 97-105.
[http://dx.doi.org/10.1007/s13659-018-0155-0] [PMID: 29453613]
[177]
Zeljković SĆ, Tan K, Siljak-Yakovlev S, Maksimović M. Essential oil profile, phenolic content and antioxidant activity of Geranium kikianum. Nat Prod Commun 2017; 12(2): 273-6.
[http://dx.doi.org/10.1177/1934578X1701200234] [PMID: 30428229]
[178]
Söhretoğlu D, Sakar MK, Sabuncuoğlu SA, Ozgüneş H, Duman H, Sterner O. Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr. Nat Prod Res 2012; 26(13): 1261-4.
[http://dx.doi.org/10.1080/14786419.2011.578071] [PMID: 21995426]
[179]
Miliauskas G, Venskutonis PR, van Beek TA. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem 2004; 85: 231-7.
[http://dx.doi.org/10.1016/j.foodchem.2003.05.007]
[180]
Petrova I, Petkova N, Ivanov I. Five edible flowers - valuable source of antioxidants in human nutrition. Int J Pharmacognosy and Phytochem Res 2016; 8: 604-10.
[181]
Sim M-O, Jang J-H, Lee H-E, Jung H-K, Cho H-W. Antioxidant effects of Geranium nepalense ethanol extract on H2O2-induced cytotoxicity in H9c2, SH-SY5Y, BEAS-2B, and HEK293. Food Sci Biotechnol 2017; 26(4): 1045-53.
[http://dx.doi.org/10.1007/s10068-017-0130-2] [PMID: 30263635]
[182]
Myagmar B-E, Aniya Y. Free radical scavenging action of medicinal herbs from Mongolia. Phytomedicine 2000; 7(3): 221-9.
[http://dx.doi.org/10.1016/S0944-7113(00)80007-0] [PMID: 11185733]
[183]
Taşkın T, Taşkın D. In vitro anti-urease, antioxidant activities and phytochemical composition of Geranium purpureum. J Food Meas Charact 2017; 11: 2102-9.
[http://dx.doi.org/10.1007/s11694-017-9594-2]
[184]
Sokmen M, Angelova M, Krumova E, et al. In vitro antioxidant activity of polyphenol extracts with antiviral properties from Geranium sanguineum L. Life Sci 2005; 76(25): 2981-93.
[http://dx.doi.org/10.1016/j.lfs.2004.11.020] [PMID: 15820508]
[185]
Wu N, Zu Y, Fu Y, et al. Antioxidant activities and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds obtained from Geranium sibiricum L. J Agric Food Chem 2010; 58(8): 4737-43.
[http://dx.doi.org/10.1021/jf904593n] [PMID: 20205393]
[186]
Yang Y-C, Li J, Zu Y-G, et al. Optimisation of microwave-assisted enzymatic extraction of corilagin and geraniin from Geranium sibiricum Linne and evaluation of antioxidant activity. Food Chem 2010; 122: 373-80.
[http://dx.doi.org/10.1016/j.foodchem.2010.02.061]
[187]
Şöhretoğlu D, Sakar MK, Sabuncuoglu SA, Özgünes H, Sterner O. Polyphenolic constituents and antioxidant potential of Geranium stepporum Davis. Rec Nat Prod 2011; 5: 22-8.
[188]
Kim M-B, Hyun S-H, Park J-S, Kang M-A, Ko Y-H, Lim S-B. Integral antioxidative capacity of extracts by pressurized organic solvent from natural plants in Jeju. J Korean Soc Food Sci Nutr 2008; 37: 1491-6.
[http://dx.doi.org/10.3746/jkfn.2008.37.11.1491]
[189]
Kim M-B, Park J-S, Lim S-B. Antioxidant activity and cell toxicity of pressurised liquid extracts from 20 selected plant species in Jeju, Korea. Food Chem 2010; 122: 546-52.
[http://dx.doi.org/10.1016/j.foodchem.2010.03.007]
[190]
Xiufen W, Hiramatsu N, Matsubara M. The antioxidative activity of traditional Japanese herbs. Biofactors 2004; 21(1-4): 281-4.
[http://dx.doi.org/10.1002/biof.552210155] [PMID: 15630212]
[191]
Lee SY, Kim HJ, Choi SW. Study on the antioxidant activity of Geranium nepalense subsp. thunbergii extract. J Soc Cosmet Sci Korea 2011; 37: 61-6.
[192]
Şöhretoğlu D, Sakar MK, Sabuncuoğlu SA, Özgünes H, Sterner O. Antioxidant galloylated flavonoids from Geranium tuberosum L. subsp. tuberosum. Turk J Chem 2009; 33: 685-92.
[193]
Ismail M, Ibrar M, Iqbal Z, et al. Chemical constituents and antioxidant activity of Geranium wallichianum. Rec Nat Prod 2009; 3: 193-7.
[194]
Gan R-Y, Kuang L, Xu X-R, et al. Screening of natural antioxidants from traditional Chinese medicinal plants associated with treatment of rheumatic disease. Molecules 2010; 15(9): 5988-97.
[http://dx.doi.org/10.3390/molecules15095988] [PMID: 20877204]
[195]
Alam MN, Bristi NJ, Rafiquzzaman M. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharm J 2013; 21(2): 143-52.
[http://dx.doi.org/10.1016/j.jsps.2012.05.002] [PMID: 24936134]
[196]
Apak R, Gorinstein S, Böhm V, Schaich KM, Özyürek M, Güçlü K. Methods of measurement and evaluation of natural antioxidant capacity/activity (IUPAC Technical Report). Pure Appl Chem 2013; 85: 957-98.
[http://dx.doi.org/10.1351/PAC-REP-12-07-15]
[197]
Carocho M, Ferreira ICFR. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 2013; 51: 15-25.
[http://dx.doi.org/10.1016/j.fct.2012.09.021] [PMID: 23017782]
[198]
Quideau S, Deffieux D, Douat-Casassus C, Pouységu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl 2011; 50(3): 586-621.
[http://dx.doi.org/10.1002/anie.201000044] [PMID: 21226137]
[199]
Hyun S-H, Jung S-K, Jwa M-K, Song C-K, Kim J-H, Lim S. Screening of antioxidants and cosmeceuticals from natural plant resources in Jeju Island. Korean J Food Sci Technol 2007; 39: 200-8.
[200]
Stevenson DE, Hurst RD. Polyphenolic phytochemicals--just antioxidants or much more? Cell Mol Life Sci 2007; 64(22): 2900-16.
[http://dx.doi.org/10.1007/s00018-007-7237-1] [PMID: 17726576]
[201]
Sabuncuoğlu S, Söhretoğlu D. Evaluation of antihemolytic and antioxidant activities of Geranium tuberosum subsp. tuberosum with in vitro models. Pharm Biol 2012; 50(11): 1374-9.
[http://dx.doi.org/10.3109/13880209.2012.675340] [PMID: 22900549]
[202]
Sapko OA, Tursunova AK, Abaildaev AO, Chebonenko OV, Krasnoshtanov AV, Utarbaeva AS. Effects of extracts of Agrimonia asiatica and Geranium collinum on lipid peroxidation and the blood antioxidant enzyme activity in rats with alloxan diabetes. Pharm Chem J 2017; 51: 596-601.
[http://dx.doi.org/10.1007/s11094-017-1659-3]
[203]
Calzada F, Yépez-Mulia L, Aguilar A. In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol 2006; 108(3): 367-70.
[http://dx.doi.org/10.1016/j.jep.2006.05.025] [PMID: 16846708]
[204]
Serkedjieva J, Manolova N. Plant polyphenolic complex inhibits the reproduction of influenza and herpes simplex virusesPlant polyphenols: Synthesis, properties, significance. New York: Plenum Press 1992; pp. 705-15.
[http://dx.doi.org/10.1007/978-1-4615-3476-1_42]
[205]
Serkedjieva J. A polyphenolic extract from Geranium sanguineum L. inhibits influenza virus protein expression. Phytother Res 1996; 10: 441-3.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199608)10:5<441:AID-PTR867>3.0.CO;2-9]
[206]
Serkedjieva J, Hay AJ. In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L. Antiviral Res 1998; 37(2): 121-30.
[http://dx.doi.org/10.1016/S0166-3542(97)00067-3] [PMID: 9588844]
[207]
Toshkova R, Nikolova N, Ivanova E, Ivancheva S, Serkedjieva J. In vitro investigation on the effect of a plant preparation with antiviral activity on the functions of mice phagocyte cells. Pharmazie 2004; 59(2): 150-4.
[PMID: 15025186]
[208]
Serkedjieva J. Influenza virus variants with reduced susceptibility to inhibition by a polyphenol extract from Geranium sanguineum L. Pharmazie 2003; 58(1): 53-7.
[PMID: 12622254]
[209]
Ivanova E, Toshkova R, Serkedjieva J. A plant polyphenol-rich extract restores the suppressed functions of phagocytes in influenza virus-infected mice. Microbes Infect 2005; 7(3): 391-8.
[http://dx.doi.org/10.1016/j.micinf.2004.11.013] [PMID: 15780977]
[210]
Serkedjieva J, Toshkova R, Antonova-Nikolova S, Stefanova T, Teodosieva A, Ivanova I. Effect of a plant polyphenol-rich extract on the lung protease activities of influenza-virus-infected mice. Antivir Chem Chemother 2007; 18(2): 75-82.
[http://dx.doi.org/10.1177/095632020701800203] [PMID: 17542152]
[211]
Murzakhmetova M, Moldakarimov S, Tancheva L, Abarova S, Serkedjieva J. Antioxidant and prooxidant properties of a polyphenol-rich extract from Geranium sanguineum L. in vitro and in vivo. Phytother Res 2008; 22(6): 746-51.
[http://dx.doi.org/10.1002/ptr.2348] [PMID: 18446846]
[212]
Serkedjieva J, Stefanova T, Krumova E, Tancheva L. Protective effect of polyphenol-rich extract on acute lung injury in influenza virus infected mice. Biotechnol Biotechnol Equip 2009; 23: 1355-9.
[http://dx.doi.org/10.1080/13102818.2009.10817669]
[213]
Serkedjieva J, Nikolova E, Kirilov N. Synergistic inhibition of influenza A virus replication by a plant polyphenol-rich extract and ε-aminocaproic acid in vitro and in vivo. Acta Virol 2010; 54(2): 137-45.
[http://dx.doi.org/10.4149/av_2010_02_137] [PMID: 20545444]
[214]
Serkedjieva J, Stefanova T, Krumova E. A fungal Cu/Zn-containing superoxide dismutase enhances the therapeutic efficacy of a plant polyphenol extract in experimental influenza virus infection. Z Natforsch C J Biosci 2010; 65(5-6): 419-28.
[http://dx.doi.org/10.1515/znc-2010-5-616] [PMID: 20653246]
[215]
Serkedjieva J. Combined use of plant polyphenol extract and rimantadine hydrochloride in vitro and in vivo reduces the emergence of drug-resistant influenza virus variants. Compt Rend Acad Bulg Sci 2009; 62: 1527-34.
[216]
Serkedjieva J, Gegova G, Mladenov K. Protective efficacy of an aerosol preparation, obtained from Geranium sanguineum L., in experimental influenza infection. Pharmazie 2008; 63(2): 160-3.
[PMID: 18380405]
[217]
Li J, Huang H, Zhou W, Feng M, Zhou P. Anti-hepatitis B virus activities of Geranium carolinianum L. extracts and identification of the active components. Biol Pharm Bull 2008; 31(4): 743-7.
[http://dx.doi.org/10.1248/bpb.31.743] [PMID: 18379075]
[218]
Serkedjieva J. Antiinfective activity of a plant preparation from Geranium sanguineum L. Pharmazie 1997; 52(10): 799-802.
[PMID: 9362094]
[219]
Mlinaric A, Kreft S, Umek A, Strukelj B. Screening of selected plant extracts for in vitro inhibitory activity on HIV-1 reverse transcriptase (HIV-1 RT). Pharmazie 2000; 55(1): 75-7.
[PMID: 10683878]
[220]
Montejano-Rodríguez JR, Almaguer-Vargas G, Gayosso-De-Lucio JA, et al. Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats. J Pharm Res 2013; 6: 709-13.
[http://dx.doi.org/10.1016/j.jopr.2013.07.013]
[221]
Sigurdsson S, Gudbjarnason S. Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum. Z Natforsch C J Biosci 2007; 62(9-10): 689-93.
[http://dx.doi.org/10.1515/znc-2007-9-1011]] [PMID: 18069242]
[222]
Youn K, Jun M. In vitro BACE1 inhibitory activity of geraniin and corilagin from Geranium thunbergii. Planta Med 2013; 79(12): 1038-42.
[http://dx.doi.org/10.1055/s-0032-1328769] [PMID: 23877922]
[223]
Yiannopoulou KG, Papageorgiou SG. Current and future treatments for Alzheimer’s disease. Ther Adv Neurol Disorder 2013; 6(1): 19-33.
[http://dx.doi.org/10.1177/1756285612461679] [PMID: 23277790]
[224]
Lorenzi M. The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res 2007; 2007: 61038.
[http://dx.doi.org/10.1155/2007/61038] [PMID: 18224243]
[225]
Choi SJ, Kim JK, Jang JM, Lim SS. Inhibitory effect of the phenolic compounds from Geranium thunbergii on rat lens aldose reductase and galactitol formation. Hanguk Yakyong Changmul Hakhoe Chi 2012; 20: 222-30.
[http://dx.doi.org/10.7783/KJMCS.2012.20.4.222]
[226]
Mashima R, Okuyama T. The role of lipoxygenases in pathophysiology; new insights and future perspectives. Redox Biol 2015; 6: 297-310.
[http://dx.doi.org/10.1016/j.redox.2015.08.006] [PMID: 26298204]
[227]
Follmer C. Ureases as a target for the treatment of gastric and urinary infections. J Clin Pathol 2010; 63(5): 424-30.
[http://dx.doi.org/10.1136/jcp.2009.072595] [PMID: 20418234]
[228]
Boisvert WA, Yu M, Choi Y, et al. Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice. BMC Complement Altern Med 2017; 17(1): 109.
[http://dx.doi.org/10.1186/s12906-017-1624-4] [PMID: 28193226]
[229]
Qiu DR, Cong J, Zhang YM, et al. Bioassay-guided isolation of herbicidal allelochemicals from essential oils of Geranium carolinianum L. and Geranium koreanum Kom. Allelopathy J 2017; 42: 65-78.
[http://dx.doi.org/10.26651/2017-42-1-1106]

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