Generic placeholder image

Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Review Article

Nyctanthes Arbor-Tristis and its Role in the Alleviation of Arthritic Pain: A Review

Author(s): Ruchi Singh, Syed M. Hasan*, Amit Verma and Sanjay K. Panda

Volume 16 , Issue 8 , 2020

Page: [1147 - 1156] Pages: 10

DOI: 10.2174/1573407216666200109105439

Price: $65


Background: A plant is a reservoir of potentially useful active chemical entities which act as drugs as well as intermediates for the discovery of newer molecules and provide newer leads for modern drug synthesis. The demand for new compounds in the field of medicine and biotechnology is centuries old and with a rise in chronic diseases and resistance to existing drugs in the field of anti-infective agents, the chemicals obtained from plant sources have been an area of attraction. The whole plant has possessed multiple pharmacological activities. This is scientifically established by in-vivo and in-vitro studies.

Methods: Various electronic databases such as PubMed, Science Direct, Scopus and Google were searched to collect the data of the present review. All the collected information is categorized into different sections as per the aim of the paper.

Results: Fifty-six research and review papers have been studied and were included in this review article. After a detailed study, we provide a significant description of various phytochemicals present in Nyctanthes arbor-tristis Linn., which is responsible for various pharmacological activities. Twenty of studied articles gives a general introduction and ethnobotanical information about the plant, two papers contained microscopic detail of leaf and fruit. Twenty papers contained information about the phytoconstituents present in different parts of Nyctanthes arbor-tristis plant and fourteen articles reported pharmacological activities like antioxidant, anti-inflammatory, antiarthritic, antimicrobial and immunobiotic activity.

Conclusion: This review explores the published research work comprising the ethnobotanical description of the subjected plant, distribution, phytochemical profile, and arthritis-related pharmacological activities.

Keywords: Nyctanthes, ethnomedicinal, arthritis, phytochemical, oleaceae, saponins.

Graphical Abstract
Fatima, G.X.; Ratchagar, J.V.; Seetharaman, S.; Sivasubramanian, S.; Somasundaram, L. Role of herbs in treatment of arthritis. Am. J. Pharm. Tech. Res., 2014, 4(1), 224-235.
Dixit, P.K.; Mittal, S. Herbal sources of antiarthritic potential: A comprehensive review. Int. J. Pharm. Biomed. Res., 2013, 4(2), 88-92.
Evans, W.C. Trease and Evans Pharmacognosy, 5th ed; W.B. Saunders Company: Singapore, 2002, pp. 1-3.
Shah, A.K.; Verma, V.K. phytochemicals and pharmacological potential of Nyctanthes arbor-tristis: A comprehensive review. Int. J. Res. Pharm. Biomed. Sci., 2012, 3(1), 420-427.
Kiew, R.; Baas, P. Nyctanthes is a member of Oleaceae. Proc. Indian Acad. Sc. (Plant Sc.), 1984, 93(3), 349-358.
Chetty, M.; Sivaji, K.; Rao, K.T. Flowering plants of Chittoor district Andhra Pradhesh; Tirupati, 2008, p. 193.
Geetha, D.H.; Jayashree, I.; Rajeswari, M. Anti-bacterial activity of leaf of Nyctanthes arbor-tristis Linn. Int. Res. J. Pharm. App. Sci., 2014, 4(4), 4-6.
Saxena, R.S.; Gupta, B.; Saxena, K.K.; Srivastava, V.K.; Prasad, D.N. Analgesic, antipyretic and ulcerogenic activity of Nyctanthes arbor tristis leaf extract. J. Ethnopharmacol., 1987, 19(2), 193-200.
[] [PMID: 3497308]
Amarite, O.; Bhuskat, P.; Patel, N.; Gadgoli, C. Evaluation of antioxidant activity of carot-enoid from Nyctanthes arbor-tristis. Int. J. Pharma Bio Sci., 2007, 2, 57-59.
Rathee, J.S.; Shyam, H.; Subrata, C. Antioxidant activity of Nyctanthes arbor-tristis leaf extract. Food Chem., 2007, 103, 1350-1357.
Omkar, A.; Jeeja, T.; Chhaya, G. Evaluation of anti-inflammatory activity of Nyctanthes arbor-tristis and Onosma echiodes. Pharmacogn. Mag., 2006, 8, 258-260.
Nadkarni, A.K. Indian Materia Medica, 3rd ed; Popular Prakashan Pvt. Ltd.: New Delhi, 1982, Vol. 1, pp. 857-858.
Kirtikar, K.R.; Basu, B.D. Indian Medicinal Plants, Sri Satguru Publications: New Delhi, 2000, 7, pp. 2110-2113
Gupta, P.; Bajpai, S.K.; Chandra, K.; Singh, K.L.; Tandon, J.S. Antiviral profile of Nyctanthes arbortristis L. against encephalitis causing viruses. Indian J. Exp. Biol., 2005, 43(12), 1156-1160.
[PMID: 16359127]
Bhosale, A.V.; Abhyankar, M.M.; Pawar, S.J.; Shoeb, K.; Patil, N. Nyctanthes arbor-tristis: A pharmacognostic review. J. Pharmacog. and phytochem., 2009, 1(2), 91-97.
Shinde, P.R.; Sali, V.A.; Patil, P.S.; Bairagi, V.A. Assessment of pharmacognostic, phyto-chemical and antibacterial potential of fruit of Nyctanthes arbor-tristis Linn. J. Pharmacogn. Phytochem., 2014, 2(6), 203-212.
Rani, C.; Chawla, S.; Mangal, M.; Mangal, A.K.; Kajla, S.; Dhawan, A.K. Nyctanthes arbortristis Linn. (Night Jasmine): A Sacred ornamental plant with immense medicinal potentials. Indian J. Tradit. Knowl., 2012, 11(3), 427-435.
Bansal, G.; Suri, K.A.; Grover, P. Comprehensive review on Nyctanthes arbortristis. Int. J. Drug Dev. & Res., 2015, 7(1), 183-193.
Rout, G.R.; Mahato, A.; Senapati, S.K. In-vitro clonal propagation of Nyctanthes arbor tristis. Hortic. Sci. (Prague), 2007, 34(2), 84-89.
Bansal, S.; Bharati, A.J.; Bansal, Y.K. In-vitro callogenesis and phytochemical screening of harsringar (Nyctanthes arbor-tristis) a multipotent medicinal tree. Int. J. Pharm. Tech. Res., 2013, 74(3), 243-246.
Shivani, S.; Ansari, S.H.; Zahiruddin, S.; Parveen, R.; Ahmad, S. Quality standards of leaves of Nyctanthes arbor-tristis Linn. Int. J. Drug Dev. & Res., 2015, 7, 3.
Talakal, T.S.; Dwivedi, S.K.; Sharma, S.R. In-vitro and in-vivo antitrypanosomal potential of Nyctanthes arbor-tristis Leaves. Pharm. Biol., 2000, 38(5), 326-329.
Paul, B.N.; Saxena, A.K. Depletion of tumor necrosis factor-alpha in mice by Nyctanthes arbor-tristis. J. Ethnopharmacol., 1997, 56(2), 153-158.
[] [PMID: 9174977]
Saxena, R.S.; Gupta, B.; Lata, S. Tranquilizing, antihistaminic and purgative activity of Nyctanthes arbor-tristis leaf extract. J. Ethnopharmacol., 2002, 81(3), 321-325.
[] [PMID: 12127232]
Khatune, N.A.; Islam, M.E.; Abdur Rahman, M.A.; Mosaddik, M.A.; Haque, M.E. In- vivo cytotoxic evaluation of a new benzofuran derivative isolated from Nyctanthes arbor-tristis L. on Ehrlich Ascite Carcinoma cells (EAC) in mice. J. Med. Dci., 2003, 3(2), 169-173.
Tandon, J.S.; Srivastava, V.; Guru, P.Y. Iridoids: A new class of leishmanicidal agents from Nyctanthes arbortristis. J. Nat. Prod., 1991, 54(4), 1102-1104.
[ ] [PMID: 1791475]
Tuntiwachwuttikul, P.; Rayanil, K.; Taylor, W.C. Chemical constituents from the flower of Nyctanthes arbor-tristis. Sci. Asia, 2003, 29, 21-30.
Khatune, N.A.; Mosaddik, M.A.; Haque, M.E.; Haque, M.E. Antibacterial activity and cytotoxicity of Nyctanthes arbor-tristis flowers. Fitoterapia, 2001, 72(4), 412-414.
[ ] [PMID: 11395266]
Deshmukh, R.D.; Pokharkar, R.D.; Takate, S.B.; Gite, V.N. Amelioration of CCl4 induced hepatosuppression by Nyctanthes arbor-tristis Linn. leaves in Wistar albino rates. Pharmacol. Online, 2007, 1, 203-208.
Gupta, R.S.; Kachhawa, J.B.S.; Sharma, R. Antispermatogenic effect of Nyctanthes arbor-tristis in male albino rats. Pharmacol. Online, 2006, 2, 261-273.
Srivastava, V.; Rathore, A.; Mashhood Ali, S.; Tandon, J.S. New Benzoic ester of loganin and 6-β-hydroxy loganin. J. Nat. Prod., 1990, 53(2), 303-308.
Singh, K.L.; Roy, R.; Srivastava, V.; Tandon, J.S.; Mishra, A. Arborside-D, A minor iridoid glucoside from Nyctanthes arbor-tristis. J. Nat. Prod., 1995, 58(10), 1562-1564.
Stuppner, H.; Muller, E.P.; Mathuram, V.; Kundu, A.B. Iridoid glycosides from Nyctanthes arbor-tristis. Phytochemistry, 1993, 32(2), 375-378.
Mathuram, V.; Bhima Rao, R.; Haldar, S.; Banerji, A.; Kundu, A.B. Occurrence of desrhamnosylverbascoside in Nyctanthes arbor-tristis and NMR studies of its acetate. J. Indian Chem. Soc., 1994, 71(4), 215-217.
Sen, A.B.; Singh, S.P. Chemical examination of Nyctanthes arbor-tristis Linn. J. Indian Chem. Soc., 1964, 41(3), 192-193.
Anjaneyule, A.S.R.; Murthy, Y.L.N.; Ramachandra Rao, L. The triterpenoid constituent of leaves the of Nyctanthes arbor-tristis Linn. J. Indian Chem. Soc., 1981, 58(8), 817-818.
Purushothaman, K.K.; Mathuram, V.; Sarada, A. Arbortristoside-A and B, two iridoid glucosides from Nyctanthes arbor-tristis. Phytochemistry, 1985, 24(4), 773-776.
Das, S.; Sasmal, D.; Basu, S.P. Anti-inflammatory and antinociceptive activity of arbortristoside-A. J. Ethnopharmacol., 2008, 116(1), 198-203.
[ ] [PMID: 18178352]
Rathore, A.; Srivastava, V.; Srivastava, K.C.; Tandon, J.S. Iridoid glucosides from Nyctan-thes arbor-tristis. Phytochemistry, 1990, 29(6), 1917-1920.
Rimpler, H.; Jinghanns, J.U. Iridoid glucosides from Nyctanthes arbor-tristis. Tetrahedron Lett., 1975, 16(29), 2423-2424.
Mathuram, V.; Patra, A.; Kundu, A.B. A phenyl propanoid glucoside from Nyctanthes arbor-tristis. J. Indian Chem. Soc., 1997, 74(8), 653-655.
Indira Iyer, R.; Mathuram, V.; Gopinath, P.M. Establishment of callus cultures of Nyctanthes arbor-tristis from juvenile explants and detection of secondary metabolites in the callus. Ind. Acad. Sci. Res. Commun., 1998, 74(3), 243.
Jain, R.; Mittal, M. A review on pharmacological and chemical documentation of Nyctanthes arbor-tristis Linn. (Harsringar). Asian J. Tradit. Med., 2011, 6(5), 183-202.
Rahman, M.M. Chemical constituents of Nyctanthes arbor-tristis Linn leaf. Nat. Prod. J., 2013, 3, 71-76.
Rathore, B.; Paul, B.; Chaudhury, B.P.; Saxena, A.K.; Sahu, A.P.; Gupta, Y.K. Comparative studies of different organs of Nyctanthes arbortristis in modulation of cytokines in murine model of arthritis. Biomed. Environ. Sci., 2007, 20(2), 154-159.
[PMID: 17624191]
Ratnasooriya, W.D.; Jayakody, J.R.A.C.; Hettiarachchi, A.D.I.; Dharmasiri, M.G. Sedative effect of hot infusion of Nyctanthes arbor-tristis on rats. Pharm. Biol., 2005, 43(2), 140-146.
Kumari, T.D.S.; Madhuri, T.D.S.; Charya, M.A.S.; Rao, K.S. Antioxidant and anticancer activity of Nyctanthes arbor-tristis. Int. J. Pharm. Pharm. Sci., 2012, 4(4), 1-3.
Saxena, R.S.; Gupta, B.; Saxena, K.K.; Singh, R.C.; Prasad, D.N. Study of anti-inflammatory activity in the leaves of Nyctanthes arbor tristis Linn.--an Indian medicinal plant. J. Ethnopharmacol., 1984, 11(3), 319-330.
[ ] [PMID: 6482481]
Bhalerao, A.R.; Desai, S.K.; Serathia, B.R.; Vartak, M.K.; Doshi, G.M. Antiarthritic studies on Nyctanthes arbor-tristis and Maharasnadi ghan. Der Pharmacia Lett., 2011, 3(4), 101-110.
Kannan, M.; Singh, R.A.J.A.; Kumar, A.T.T.; Jegatheswari, P.; Subburayalu, S. Studies on Immuno bioactivities of Nyctanthes arbor-tristis (Oleaceae). Afr. J. Microbiol. Res., 2007, 1(6), 88-91.
Akki, K.S.; Krishnamurthy, G.; Bhojanaik, H.S. Phytochemical investigations and in vitro evaluation of Nyctanthes arbor-tristis leaf extracts for antioxidant property. J. Pharm. Res., 2009, 2(4), 752-755.
Pandey, R.S. Anti-oxidant activity of Nyctanthes arbor-tristis Linn. Asian J. Pharmacy and Life Sci., 2012, 2(2), 360.

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy