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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

New Development of Novel Berberine Derivatives against Bacteria

Author(s): Faisal Jamshaid, Jun Dai* and Li Xi Yang

Volume 20, Issue 8, 2020

Page: [716 - 724] Pages: 9

DOI: 10.2174/1389557520666200103115124

Price: $65

Abstract

Many berberine derivatives have been synthesized for their antibacterial activity in the past years. In order to elucidate their new Structural Activity Relationship (SAR), the recently synthesized berberine derivatives are reviewed. The newly synthesized berberine derivatives are reported in this review with novel modifications on the berberine structure at various positions. It is hoped that this article would help scientists to design and synthesize new berberine derivatives with high potency and a broad spectrum of antimicrobial activities, more effectiveness and lower toxicity for improved antimicrobial therapy. These berberine derivatives could be developed as novel antibacterial agents to treat patients with infectious diseases, especially caused by resistant bacteria.

Keywords: Antimicrobial therapy, oregon grape, tree turmeric, traditional medicine, lipopolysaccharide, antidepressant.

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