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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Recognition of Fungal Components by the Host Immune System

Author(s): Laura C. García-Carnero, José A. Martínez-Álvarez*, Luis M. Salazar-García, Nancy E. Lozoya-Pérez, Sandra E. González-Hernández and Alma K. Tamez-Castrellón

Volume 21, Issue 3, 2020

Page: [245 - 264] Pages: 20

DOI: 10.2174/1389203721666191231105546

Price: $65

Abstract

By being the first point of contact of the fungus with the host, the cell wall plays an important role in the pathogenesis, having many molecules that participate as antigens that are recognized by immune cells, and also that help the fungus to establish infection. The main molecules reported to trigger an immune response are chitin, glucans, oligosaccharides, proteins, melanin, phospholipids, and others, being present in the principal pathogenic fungi with clinical importance worldwide, such as Histoplasma capsulatum, Paracoccidioides brasiliensis, Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis, and Sporothrix schenckii. Knowledge and understanding of how the immune system recognizes and responds to fungal antigens are relevant for the future research and development of new diagnostic tools and treatments for the control of mycosis caused by these fungi.

Keywords: Host-pathogen, chitin, glucans, antigen, immune response, virulence factor.

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