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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Cellular and Molecular Mechanisms of Antithrombogenic Plants: A Narrative Review

Author(s): Tatiane C. Mendes, Francislaine Aparecida dos Reis Lívero, Priscila de Souza, Karimi S. Gebara and Arquimedes Gasparotto Junior*

Volume 26, Issue 1, 2020

Page: [176 - 190] Pages: 15

DOI: 10.2174/1381612825666191216125135

Price: $65


Heart attack, stroke, and deep vein thrombosis are among the conditions that alter blood coagulation and are modulated by antithrombogenic drugs. Natural products are an important source of antithrombogenic agents and have been considered remarkable alternatives with greater efficacy and usually with fewer side effects. However, the efficacy and toxicity of many of these plants that are used in traditional medicine must be scientifically tested. Despite a large number of published articles that report that plants or plant-derived components may act as antithrombogenic agents, few studies have investigated the mechanism of action of medicinal plants. This review presents the current knowledge about the major cellular and molecular mechanisms of antithrombogenic plants and their main components. Many well-established mechanisms (e.g., platelet aggregation, coagulation factors, and thrombolysis) are related to the antithrombogenic activity of many natural products. However, the central pathways that are responsible for their activity remain unclear. Further studies are needed to clarify the central role of each of these pathways in the pleiotropic response to these agents.

Keywords: Alternative therapy, anticoagulant, antiplatelet, herbal medicine, thrombolytic, antithrombogenic.

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