Generic placeholder image

Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Comparative Genomic Hybridization: A Valuable Tool for Genome-Scale Analysis of Rodent Cancer Models

Author(s): R. Kappler and H. Scherthan

Volume 2, Issue 4, 2001

Page: [325 - 335] Pages: 11

DOI: 10.2174/1389202013350706

Price: $65


Comparative genomic in situ hybridization (CGH) studies have marked regions of unbalanced genomic alterations in a variety of human solid and hematological malignancies. Subsequent molecular analysis helped to pinpoint genes contributing to tumorigenic development and progression. CGH has since become a routine tool in molecular diagnostics and cancer research. Since mice and rats represent major model systems for human malignancies, CGH was soon adapted for tracing DNA copy number changes in experimental rodent tumor genomes. A stronghold of this approach is the potential transfer of information to the human situation by use of comparative maps of mouse and rat, and the human genome. This allows for an evaluation and validation of rodent tumor models at the genomic level. This review will illuminate the insights obtained by CGH analysis of rodent tumor genomes and the comparative transfer of this information between rodents and human.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy