Abstract
Postaglandins(PG) and low-density lipoproteins (LDL) both are playing a key role in atherogenesis. Their interaction at the local vascular level is of central relevance in plaque formation and progression. Details of these complex actions however, still need to be elucidated. Lipoproteins are influencing the PG-production of arterial wall cells and platelets, while PGs in turn have been shown to regulate lipoprotein receptor binding and entry into the arterial wall. Modification of LDL severely influences arterial wall trapping and foam cell formation. During LDL-modification, isoprostanes, a new family of compounds generated by free radical catalysed action, independent of cyclooxygenase, are formed. 8-epi PGF 2a the most well known member exerts a great variety of proatherogenic actions, among them vasoconstriction and platelet activation it also serves as a mitogen and stimulator of endothelin release. The influence of various eicosanoids on lipoprotein modification, however, has not been assessed yet.
Keywords: Lipid Modification, low density lipoproteins, PG production, LDL modification, proatherogenic actions, cholesteryl esters, Lipid Peroxidation, tocopheroxyl radical TO, endothelial integrity
Current Pharmaceutical Design
Title: Prostaglandins and Lipid Modification
Volume: 7 Issue: 6
Author(s): Grazyna Sobal and H. Sinzinger
Affiliation:
Keywords: Lipid Modification, low density lipoproteins, PG production, LDL modification, proatherogenic actions, cholesteryl esters, Lipid Peroxidation, tocopheroxyl radical TO, endothelial integrity
Abstract: Postaglandins(PG) and low-density lipoproteins (LDL) both are playing a key role in atherogenesis. Their interaction at the local vascular level is of central relevance in plaque formation and progression. Details of these complex actions however, still need to be elucidated. Lipoproteins are influencing the PG-production of arterial wall cells and platelets, while PGs in turn have been shown to regulate lipoprotein receptor binding and entry into the arterial wall. Modification of LDL severely influences arterial wall trapping and foam cell formation. During LDL-modification, isoprostanes, a new family of compounds generated by free radical catalysed action, independent of cyclooxygenase, are formed. 8-epi PGF 2a the most well known member exerts a great variety of proatherogenic actions, among them vasoconstriction and platelet activation it also serves as a mitogen and stimulator of endothelin release. The influence of various eicosanoids on lipoprotein modification, however, has not been assessed yet.
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Cite this article as:
Sobal Grazyna and Sinzinger H., Prostaglandins and Lipid Modification, Current Pharmaceutical Design 2001; 7 (6) . https://dx.doi.org/10.2174/1381612013397933
DOI https://dx.doi.org/10.2174/1381612013397933 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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