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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Exosomes in Sepsis and Inflammatory Tissue Injury

Author(s): Eun J. Park*, Michael G. Appiah, Phyoe K. Myint, Arong Gaowa, Eiji Kawamoto and Motomu Shimaoka*

Volume 25, Issue 42, 2019

Page: [4486 - 4495] Pages: 10

DOI: 10.2174/1381612825666191116125525

Price: $65


Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as proinflammatory cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological lipid bilayer nanoparticles secreted via the endosomal pathway of cells, have recently emerged as important cargos that carry multiple mediators critical for the pathogenesis of sepsis-associated organ dysfunctions. Here we will review current knowledge on the exosomes in sepsis and relevant inflammatory tissue injuries.

Keywords: Sepsis, septic shock, inflammatory tissue injury, exosome, extracellular vesicle, integrin, miRNA

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