miR-21 and miR29-a: Potential Molecular Biomarkers for HPV Genotypes and Cervical Cancer Detection

Title:miR-21 and miR29-a: Potential Molecular Biomarkers for HPV Genotypes and Cervical Cancer Detection

Volume: 9 Issue: 4

Author(s): Sara Zamani, Seyed Masoud Hosseini and Amir Sohrabi*

Affiliation:

• Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm,Sweden

Keywords: Biomarker, cervical cancer, HPV, miR-21, miR-29a, Receiver Operating Characteristic (ROC).

Abstract:

Background and objective: This study aimed to assess miR21 and miR-29a diagnostic usefulness for HPV infection and Cervical Cancer (CC) detection.

Methods: miRs extraction has been performed on HPV-positive, CC and negative control of 43, 50 and 46 individuals, respectively. The expression level of miRs has been analyzed using Real-Time RT-PCR.

Results: There was a correlation between the expression of miRs and the Receiver Operating Characteristic (ROC) analysis in CC and HPV-positive patients.

Conclusion: The correlation between expressions of miRs is notable. ROC curve analysis could be applied in molecular diagnostic exposure for CC related to HPV infections.

Cite this article as:

Zamani Sara , Hosseini Masoud Seyed and Sohrabi Amir *, miR-21 and miR29-a: Potential Molecular Biomarkers for HPV Genotypes and Cervical Cancer Detection, MicroRNA 2020; 9 (4) . https://dx.doi.org/10.2174/2211536609666191115110015