Research Article

miR-21 and miR29-a: Potential Molecular Biomarkers for HPV Genotypes and Cervical Cancer Detection

Author(s): Sara Zamani, Seyed Masoud Hosseini and Amir Sohrabi*

Volume 9 , Issue 4 , 2020

Page: [271 - 275] Pages: 5

DOI: 10.2174/2211536609666191115110015

Abstract

Background and objective: This study aimed to assess miR21 and miR-29a diagnostic usefulness for HPV infection and Cervical Cancer (CC) detection.

Methods: miRs extraction has been performed on HPV-positive, CC and negative control of 43, 50 and 46 individuals, respectively. The expression level of miRs has been analyzed using Real-Time RT-PCR.

Results: There was a correlation between the expression of miRs and the Receiver Operating Characteristic (ROC) analysis in CC and HPV-positive patients.

Conclusion: The correlation between expressions of miRs is notable. ROC curve analysis could be applied in molecular diagnostic exposure for CC related to HPV infections.

Keywords: Biomarker, cervical cancer, HPV, miR-21, miR-29a, Receiver Operating Characteristic (ROC).

Graphical Abstract

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