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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article (Mini-Review)

Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer

Author(s): Adrian Bartoszek, Jakub Fichna, Aleksandra Tarasiuk, Agata Binienda, Adam Fabisiak, Julia B. Krajewska, Paula Mosińska, Karolina Niewinna and Maciej Salaga*

Volume 21 , Issue 14 , 2020

Page: [1397 - 1404] Pages: 8

DOI: 10.2174/1389450120666191112141901

Price: $65


Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatment of CRC has improved in the last few years, the side effects of these approaches cannot be neglected. Recently, members of the family of free fatty acid receptors (FFARs) have become attractive pharmacological targets in many diseases, including asthma; studies also point to their role in carcinogenesis. Here, we discuss current knowledge and future directions in FFAR research related to CRC. Contradictory results of FFARs modulation may derive from the pleiotropic effects of FFAR ligands, receptor distribution and different signal transduction. Hence, we indicate directions of further studies to fully use the potential of FFARs in CRC.

Keywords: Free fatty acids receptors, colorectal cancer, fatty acids, G protein-coupled receptors, cancer, diet.

Graphical Abstract
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