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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Research Article

Evaluation of the Status of Salivary Antioxidants in Dental Caries

Author(s): Seyedeh Sareh Hendi, Mohammad Taghi Goodarzi, Abbas Moghimbeigi and Fatemeh Ahmadi-Motamayel*

Volume 20, Issue 6, 2020

Page: [816 - 821] Pages: 6

DOI: 10.2174/1871526519666191031100432

Price: $65


Background and Aim: Dental caries is a communicable and the most prevalent infectious disease worldwide. Salivary oxidative stress and antioxidants may play a pivotal role in caries prevention, progression and pathogenesis. In this study, salivary superoxide dismutase, peroxidase, glutathione peroxidase, catalase and uric acid levels were evaluated in dental caries.

Materials and Methods: One hundred male and female students in two groups (n=50) were subdivided into caries-active and caries-free (25) groups. Whole saliva samples were collected in the morning, and the salivary antioxidant levels were measured by a spectrophotometric assay. The data were analyzed using SPSS.

Results: The caries-active group had higher peroxidase, uric acid, catalase and glutathione peroxidase levels, and lower superoxide dismutase level as compared to the caries-free group. The comparison between males and females showed lower peroxidase, catalase and uric acid levels and higher glutathione peroxidase levels in the female group.

Conclusion: The caries-active group had altered salivary antioxidant levels. Therefore, it was concluded that salivary antioxidants have significant effects on oral and dental health.

Keywords: Dental caries, enzymatic antioxidants, molecular antioxidants, saliva, SPSS, glutathione peroxidase.

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