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Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Human Microbiome and Allergic Diseases in Children: Pathogenetic Role and Therapeutic Options

Author(s): Paola Musso, Elena Chiappini * and ">Roberto Bernardini

Volume 16 , Issue 2 , 2020

Page: [89 - 94] Pages: 6

DOI: 10.2174/1573396315666191025110849


The recent and extensive study of the microbiome has provided an enormous amount of data concerning the type and possible functions of microorganisms present in the gut, airways, genital tract, and skin. These data showed interpersonal differences in the composition of the microbiome and these differences suggest a link between the microbiome, the immune modulation, and the pathogenesis of allergic diseases.

This research is particularly relevant in paediatrics, since allergic diseases are constantly increasing and there is evidence in the paediatric age that shows that the composition of the microbiome in the foetal and neonatal period plays a key role in the development of the immune system: vaginal delivery, breastfeeding, childhood spent in rural environments and/or in contact with animals result in a greater biodiversity of the microbiome with the presence of protective species that reduce the activation of Th2 lymphocytes, involved in allergic reactions.

Further studies are necessary to better understand the microbiota role in the pathogenesis of atopy in order to understand if specific probiotics and prebiotics, administered orally or topically, can affect the microbiota composition and modulate immune system functions, producing a therapeutic effect in the treatment of allergic diseases.

This narrative review analysed the available literature regarding the correlation between the microbiome and the development of allergic diseases and with special focus on paediatric studies. The skin, gut or lung dysbiosis can be a cofactor in the pathogenesis of allergies and the remodulation of the microbiome becomes an important therapeutic challenge.

Keywords: Allergy, asthma, atopic, children, dermatitis, dysbiosis, food allergy, infant, microbiome, microbiota, pediatric.

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Blaser MJ. The microbiome revolution. J Clin Invest 2014; 124(10): 4162-5.
[] [PMID: 25271724]
Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med 2018; 24(4): 392-400.
[] [PMID: 29634682]
Huang YJ, Marsland BJ, Bunyavanich S, et al. The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol 2017; 139(4): 1099-110.
[] [PMID: 28257972]
Frei R, Akdis M, O’Mahony L. Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol 2015; 31(2): 153-8.
[] [PMID: 25594887]
Cezmi A. Akdis and Scott H Sicherer pp Allergy and the Immunologic Basis of Atopic Disease. 20th ed. Nelson Textbook of Pediatrics 2016; pp. 1074-7.
Gerlich J, Benecke N, Peters-Weist AS, et al. Pregnancy and perinatal conditions and atopic disease prevalence in childhood and adulthood. Allergy 2018; 73(5): 1064-74.
[] [PMID: 29193127]
Zimmermann P, Messina N, Mohn WW, Finlay BB, Curtis N. Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review. J Allergy Clin Immunol 2019; 143(2): 467-85.
[] [PMID: 30600099]
Di Cicco ME, Licari A, Leone M, et al. Impatto del microbioma (polmonare e intestinale) sull’asma Rivista di Immunologia e Allergologia Pediatrica 2018; 2: 26-32..
Sullivan A, Hunt E, MacSharry J, Murphy DM. The microbiome and the pathophysiology of asthma. Respir Res 2016; 17(1): 163.
[] [PMID: 27919249]
Global Initiative for Asthma; Global Strategy for Asthma Management and Prevention 2018.Available from:.
Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways. PLoS One 2010; 5(1)e8578
[] [PMID: 20052417]
Dickson RP, Erb-Downward JR, Freeman CM, et al. Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography. Ann Am Thorac Soc 2015; 12(6): 821-30.
[] [PMID: 25803243]
Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007; 357(15): 1487-95.
[] [PMID: 17928596]
Gray LE, O’Hely M, Ranganathan S, Sly PD, Vuillermin P. The maternal diet, gut bacteria, and bacterial metabolites during pregnancy influence offspring asthma. Front Immunol 2017; 8: 365.
[] [PMID: 28408909]
Fujimura KE, Demoor T, Rauch M, et al. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci USA 2014; 111(2): 805-10.
[] [PMID: 24344318]
Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20(2): 159-66.
[] [PMID: 24390308]
Berin MC, Sampson HA. Mucosal immunology of food allergy. Curr Biol 2013; 23(9): R389-400.
[] [PMID: 23660362]
Branum AM, Lukacs SL. Food allergy among U.S. children: trends in prevalence and hospitalizations. NCHS Data Brief 2008; (10): 1-8.
[PMID: 19389315]
Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days - intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol 2014; 25(5): 428-38.
[] [PMID: 24899389]
Penders J, Thijs C, Vink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006; 118(2): 511-21.
[] [PMID: 16882802]
Biasucci G, Benenati B, Morelli L, Bessi E, Boehm G. Cesarean delivery may affect the early biodiversity of intestinal bacteria. J Nutr 2008; 138(9): 1796S-800S.
[] [PMID: 18716189]
Sjögren YM, Jenmalm MC, Böttcher MF, Björkstén B, Sverremark-Ekström E. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy 2009; 39(4): 518-26.
[] [PMID: 19220322]
Thompson-Chagoyan OC, Vieites JM, Maldonado J, Edwards C, Gil A. Changes in faecal microbiota of infants with cow’s milk protein allergy--a Spanish prospective case-control 6-month follow-up study. Pediatr Allergy Immunol 2010; 21(2 Pt 2): e394-400.
[] [PMID: 19889194]
Bunyavanich S, Shen N, Grishin A, et al. Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol 2016; 138(4): 1122-30.
[] [PMID: 27292825]
Stefka AT, Feehley T, Tripathi P, et al. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci USA 2014; 111(36): 13145-50.
[] [PMID: 25157157]
Berni Canani R, Di Costanzo M, Bedogni G, et al. Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow’s milk allergy: 3-year randomized controlled trial. J Allergy Clin Immunol 2017; 139(6): 1906-1913.e4.
[] [PMID: 28043872]
Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010; 107(26): 11971-5.
[] [PMID: 20566857]
Baviera G, Capra L, Cipriani F, et al. Ecosistema microbico nella cute sana e nell’eczema Rivista di Immunologia e Allergologia Pediatrica 2014 Jan; 2-7..
Petersen EBM, Skov L, Thyssen JP, Jensen P. Role of the gut microbiota in atopic dermatitis: a systematic review. Acta Derm Venereol 2019; 99(1): 5-11.
[PMID: 30085318]
Kong HH, Oh J, Deming C, et al. NISC Comparative Sequence Program. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 2012; 22(5): 850-9.
[] [PMID: 22310478]
Galli E, et al. Il “perché” dello skin care nella dermatite atopica. Rivista di Immunologia e Allergologia Pediatrica 2018; 3: 22-30.
Lunjani N, Satitsuksanoa P, Lukasik Z, Sokolowska M, Eiwegger T, O’Mahony L. Recent developments and highlights in mechanisms of allergic diseases. Microbiome Allergy 2018; 73(12): 2314-27.
[] [PMID: 30325537]

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