Abstract
The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.
Keywords: Candida Proteases, Antifungal Therapy, secreted acid proteases (SAP), Candida fungal species, fluconazole, echinocandin B, amphotericin, HIV PROTEASE INHIBITORS
Current Medicinal Chemistry
Title: Candida Proteases and Their Inhibition Prospects for Antifungal Therapy
Volume: 8 Issue: 8
Author(s): K. Stewart and C. Abad-Zapatero
Affiliation:
Keywords: Candida Proteases, Antifungal Therapy, secreted acid proteases (SAP), Candida fungal species, fluconazole, echinocandin B, amphotericin, HIV PROTEASE INHIBITORS
Abstract: The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.
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Cite this article as:
Stewart K. and Abad-Zapatero C., Candida Proteases and Their Inhibition Prospects for Antifungal Therapy, Current Medicinal Chemistry 2001; 8 (8) . https://dx.doi.org/10.2174/0929867013372698
DOI https://dx.doi.org/10.2174/0929867013372698 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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