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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

A Review on the Synthetic Routes to β-Keto Amides

Author(s): Salwa E. M. El-Meligie, Nadia A. Khalil, Hala B. El-Nassan* and Ahmed A. M. Ibraheem

Volume 23, Issue 19, 2019

Page: [2005 - 2015] Pages: 11

DOI: 10.2174/1385272823666191021120336

Price: $65

Abstract

This review summarizes the data published on the methods of preparation of β- keto amides as a versatile synthon for many heterocyclic rings and asymmetric urea derivatives. Based on the starting materials used for the synthesis of β-keto amides, eight methods were reported including β-keto acids and their derivatives, Meldrum’s acid and their derivatives, diketene, 2,6-dimethyl-1,3-dioxin-4-one derivatives (TMD), α-diazo ketones, enamines and enolates, acetamides and their derivatives and reduction of certain Passerini products.

Keywords: β-Keto amides, diketene, β-keto acids, Meldrum’s acid, enamines, enolates, Passerini products.

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