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Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Research Article

Studies on X-Ray Diffraction, Thermogravimetric Stability, Antibacterial- Antifungal Activity of Fe(II), Ni(II), Cu(II) Metal Chloroquine Complexes Against Bacterial Strains and Fungal Spore

Author(s): Mukesh Shankarrao Kadam*, Sachin Atmaram Khiste, Satish Ashruba Dake and Bhimrao Chintamanrao Khade*

Volume 18, Issue 4, 2020

Page: [339 - 351] Pages: 13

DOI: 10.2174/2211352517666191021090630

Abstract

Introduction: Synthesis of new coordination complexes has gained a great interest of the inorganic chemists as well as researchers.

Methods: A literature survey has revealed that main group elements as well as transition metals with ligand like Schiff’s base and many drug have the ability to form a coordinate bond. 3d-series of metal complex with chloroquine as a ligand was synthesized (ML2) stoichiometrically and characterized by conductivity, melting point, UV-spectra, TGA and X-ray analysis of coordination complexes and anti-microbial activity.

Results: The synthesized metal complex was evaluated for in vitro antibacterial and antifungal activity against the bacterial strains such as Plasmodium falciparum, Pseudomonas aeruginosa, E. coli, Streptococcus, Bacillus, Staphylococcus aureus and Aspergillus niger.

Conclusion: The metal complex shows very potential antibacterial as well as antifungal activity like a commercial drug. Inorganic chemistry gives us good opportunities to use metal complexes as Pharmacological agents.

Keywords: Antimicrobial activity, coordination complexes, chloroquine, conductivity, metal complex, ligand.

Graphical Abstract
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