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ISSN (Print): 1872-2113
ISSN (Online): 2212-4039

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Review Article

Medicated Chewing Gums: Recent Patents and Patented Technology Platforms

Author(s): Prerna Kaushik and Deepak Kaushik*

Volume 13, Issue 3, 2019

Page: [184 - 191] Pages: 8

DOI: 10.2174/1872211313666191010093148

Abstract

The reason that the oral route attained such acceptance may be ascribed to its affluence of administration. Over the years, patient convenience- oriented exploration in the area of drug delivery has introduced potential innovative medicine delivery systems. The elegant drug delivery system is an amalgamation of science and dexterity with therapeutic prospect and presentability. It involves the administration of medications in a groundbreaking fashion with the assistance of cosmetics, wearable devices and oral drug delivery system which can also be used for ornamental purposes. Out of which, therapeutic chewing gum offers a highly suitable and amenable technique of dosing medications comprising children and elderlies. It is a potentially convenient means of administering medications either locally or systematically via the oral cavity. It bids innumerable gains over conventional drug delivery methods. Moreover, medicinal chewing gums involve the dynamic and constant masticatory actions for drug release. Currently, enriched expertise has made it promising to advance and fabricate medicated chewing gum with predefined properties and it could be a marketable triumph in the future. Apprehending this, several investigators and pharmaceutical companies are now engaged in developing innovative practices vis-à-vis medicated chewing gums by filing several patents in this area. The present manuscript also delivers a gestalt of various patented technology platforms based on different methods/ mechanisms employed for the preparation of medicated chewing gums.

Keywords: Medicated chewing gums, patented technology platforms, pharmagum, revolymer technology, directly compressible gum, oral cavity.

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[1]
Heema N, Stuti G. Medicated chewing gums-Updated Review. Int J Pharm Res Dev 2010; 2(8): 66-76.
[2]
Athanikar NK, Gubler SA. Process for manufacturing a pharmaceutical chewing gum. US6322828 (2001)
[3]
Yang RK. Encapsulation composition for use with chewing gum and edible products. US4740376 (1988)
[4]
Aslani A, Rostami F. Medicated chewing gum, a novel drug delivery system. J Res Med Sci 2015; 20(4): 403-11.
[PMID: 26109999]
[5]
Koch ER, Abbazia LP. Process for preparing chewing gum base using solid elastomer. US4187320 (1980)
[6]
Keizo M, Yokomichi FY. Process for the preparation of chewing gum. US4000321 (1976)
[7]
Eisenstadt B, Cash PA, Bakal AI. Chewing gum containing cough suppressing agent. US5846557 1998.
[8]
Chaudhary SA, Shahiwala AF. Medicated chewing gum- A potential drug delivery system. Expert Opin Drug Deliv 2010; 7(7): 871-85.
[http://dx.doi.org/10.1517/17425247.2010.493554] [PMID: 20560779]
[9]
Shrinivas B, Kane RN, Dhat SP. Medicated chewing gum: A new reformulation technique. Pharm News 2005; 3(4): 1.http://www.pharmainfo. net
[10]
Gunjal P, Kalmegh T, Gadhave M, Jadhav S. A review on medicated chewing gum as a novel drug delivery system. Int J Uni Pharm L Sci 2012; 2(4): 194-206.
[11]
Mehta F, Keservani RK, Karthikeyan C, Trivedi P. Chewing gum as a drug delivery system. Arch Appl Sci Res 2010; 2(2): 79-99.
[12]
Niazi S, Shemesh A. Chewing gum containing medicaments and taste masking. US4639368A (1985)
[13]
Gudas VV, Reed MA, Schnell PG, et al. Method of controlling release of caffeine in chewing gum. US6165516 (1998)
[14]
Patel A, Shukla V, Shrimal N, Sharma P. Chewing gum as a drug delivery system. Int J Pharm Sci Res 2011; 2(4): 748-57.
[15]
Pagare PK, Chandrakant S, Varsha M. Medicated chewing gum: A novel drug delivery system. J Appl Pharm Sci 2012; 2(6): 40-54.
[http://dx.doi.org/10.7324/JAPS.2012.2706]
[16]
https://www.uspto.gov/ [Accessed on: January 19, 2019]
[17]
http://ep.espacenet.com/ [Accessed on: January 19, 2019]
[18]
Biswal PK, Anantkumar P. An updated review on medicated chewing gum. Int J Adv Pharm Bio Chem 2013; 2: 351-9.
[19]
Rassing MR, Jacobsen J. Medicated gum modified release drug delivery technology. New York: Marcel Dekker Inc. 2003.
[20]
Rassing MR. Chewing gum as a drug delivery system. Adv Drug Deliv Rev 1994; 13: 89-121.
[http://dx.doi.org/10.1016/0169-409X(94)90028-0]
[21]
Parmar VW, Thosar M. A comprehensive review on: Medicated chewing gum. Int J Res Pharm Biomed Sci 2012; 3: 894-907.
[22]
William PV, Millind T. A comprehensive review on medicated chewing gum. Int J Pharm Biomed Res 2012; 3: 894-907.
[23]
Segale L, Conti S, Machiste EO, Salini A, Conte U. Preparation and evaluation of release characteristics of 3TabGum, a novel chewing device. Eur J Pharm Sci 2015; 24: 487-93.
[24]
Subraman R, John M, Jack E, Edward J, Carlos D, Gitchell J. Medicated chewing gum delivery system for nicotine. US6344222 2002.
[25]
El Assassy AE, Amin MM, Abdelbary AA. Immediate release three-layered chewing gum tablets of fenoprofen calcium: Preparation, optimization and bioavailability studies in healthy human volunteers. Drug Dev Ind Pharm 2012; 38(5): 603-15.
[http://dx.doi.org/10.3109/03639045.2011.620967] [PMID: 21988149]
[26]
Gavaskar B, Ramana V, Rao YM. Medicated chewing gum- A novel approach to improve patient compliance. Int J Pharma Bio Sci 2011; 2: 23-32.
[27]
Zyck DJ, Greenberg MJ, Barkla DG, Marske SW, Schnell PG, Mazzone P. Method of making coated chewing gum products containing various antacids. US6645535 (2003)
[28]
Kvist C, Andersson SB, Fors S, Wennergren B, Berglund J. Apparatus for studying in vitro drug release from medicated chewing gums. Int J Pharm 1999; 189(1): 57-65.
[http://dx.doi.org/10.1016/S0378-5173(99)00236-7] [PMID: 10518685]
[29]
West D. Medicated chewing gum. US20030118691 (2003)
[30]
Carsten A. Tobacco alkaloid releasing chewing gum. WO2006000232 2006
[31]
Subraman R, Henningfield D. Medicated chewing gum delivery System for nicotine. US6344222 (1999)
[32]
Hughes L. Buccal Dissolution of active substances. US0087457 (2003)
[33]
Silagy C, Lancaster T, Stead L, Mant D, Fowler G. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev 2004; 3(3) CD000146
[PMID: 15266423]
[34]
Britt DM, Cohen LM, Collins FL, Cohen ML. Cigarette smoking and chewing gum: Response to a laboratory-induced stressor. Health Psychol 2001; 20(5): 361-8.
[http://dx.doi.org/10.1037/0278-6133.20.5.361] [PMID: 11570650]
[35]
Aslani A, Rafiei S. Design formulation and evaluation of nicotine chewing gum. Adv Biomed Res 2012; 1: 57.
[http://dx.doi.org/10.4103/2277-9175.100175] [PMID: 23326788]
[36]
Nijhawan P. Medicated gumstick for treatment in antiinflammatory conditions and prophylaxis against NSAIDs Gastropathy. US2007/0003490 (2007)
[37]
Sarath CC, Neetu VKV. Development and characterization of medicated chewing gum containing indomethacin IP. Int J Appl Pharm Biol Res 2016; 1(2): 150-7.
[38]
Amin A, Norman G. Chewing gum formulation and method of making the same. US7208186B2 2007.
[39]
Badetti R. Composition for medicated chewing gums: Process for manufacturing the same and tablets so obtained. EP1162946 2009.
[40]
Badetti R. A process for the preparation of medicated chewing gums. EP1408769 (2010)
[41]
Andersan C. Stable MCG comprising cyclodextrin inclusion complexes. 20130022652 (2013)
[42]
Chaudhary SA, Shahiwala AF. Directly compressible medicated chewing gum formulation for quick relief from common cold. Int J Pharm Investig 2012; 2(3): 123-33.
[http://dx.doi.org/10.4103/2230-973X.104395] [PMID: 23373003]
[43]
Cho W. Formulation of medicated chewing gum comprising antihistamine. KR101736038 (2017)
[44]
Lisa B, Robert E. Method of manufacturing MCG without cooling. US2017281539A1 (2017)
[45]
Bindi GC, Vipul PP, Tushar RD. Medicated chewing gum: A Review. Pharmatotur-Art 2011; 1047: 1-5.
[46]
Available from: https://wwwbusiness-reviewwebinarscom/ webinar/Pharma/Medicated/ [Accessed on: October 10, 2018]
[47]
Pittler MH, Stevinson C, Ernst E. Chromium picolinate for reducing body weight: Meta-analysis of randomized trials. Int J Obes Relat Metab Disord 2003; 27(4): 522-9.
[http://dx.doi.org/10.1038/sj.ijo.0802262] [PMID: 12664086]
[48]
Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006; 29(8): 1826-32.
[http://dx.doi.org/10.2337/dc06-0254] [PMID: 16873787]
[49]
Nemeth R, Benowitz NL, Robinson N, Hennigfield GE. Nicotine gum: Chew rate subjective effects and plasma nicotine. Pharmacol Biomed Behav 1988; 29: 747-51.
[http://dx.doi.org/10.1016/0091-3057(88)90197-9]
[50]
Cosgrove T, Erol AH, Voss MG. Chewing gum composition. US12449622 2008.
[51]
Kubota RM, Thomas SM, Chapdelaine AH, Courtright SB. Method of making chewing gum. US4806364 (1989)
[52]
Jensen E, Lokind KB, Pedersen M, Rassing MR. Chewing gum as a drug delivery system- Influence of additives upon the rate of drug release of metronidazole and propranolol hydrochloride from chewing gum. Farmaci Sci Ed 1988; 16: 94-7
[53]
Cherukuri SR, Hriscisce F, Wei YC. Reduced calorie chewing gums and method. US4765991 (1988)
[54]
Pedersen M, Rassing MR. Miconazole chewing gum as a drug delivery system: Application of solid dispersion technique and lecithin. Drug Dev Ind Pharm 1990; 16: 2015-30.
[http://dx.doi.org/10.3109/03639049009023638]
[55]
Pedersen M, Rassing MR. Miconazole and miconazole nitrate chewing gum as drug delivery systems: A practical approach of solid dispersion technique. Drug Dev Ind Pharm 1990; 16(1): 55-74.
[http://dx.doi.org/10.3109/03639049009115986]
[56]
Pedersen M, Rassing MR. Miconazole chewing gum as a drug delivery system test of release promoting additives. Drug Dev Ind Pharm 1991; 17(3): 411-20.
[http://dx.doi.org/10.3109/03639049109043835]
[57]
Rindum JL, Holmstrup P, Pedersen M, Rassing MR, Stoltze K. Miconazole chewing gum for treatment of chronic oral candidosis. Scand J Dent Res 1993; 101(6): 386-90.
[http://dx.doi.org/10.1111/j.1600-0722.1993.tb01137.x] [PMID: 8290882]
[58]
Na DH, Faraj J, Capan Y, Leung KP, DeLuca PP. Chewing gum of antimicrobial decapeptide (KSL) as a sustained antiplaque agent: Preformulation study. J Control Release 2005; 107(1): 122-30.
[http://dx.doi.org/10.1016/j.jconrel.2005.05.027] [PMID: 16009443]
[59]
Na DH, Faraj J, Capan Y, Leung KP, DeLuca PP. Stability of antimicrobial decapeptide (KSL) and its analogues for delivery in the oral cavity. Pharm Res 2007; 24(8): 1544-50.
[http://dx.doi.org/10.1007/s11095-007-9274-8] [PMID: 17380259]
[60]
https://www.dnaindia.com/health/report-first-chewing-gum-contraceptive-pills-hit-market-1068369 [Accessed on May 1, 2019
[61]
Plaumann H, Castellano C. Chlorine dioxide based gum. EP2429308 (2012)
[62]
Holme SK, Luo SJ. Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same. US6479071 (2000)
[63]
Witt J, Wimalasena R, Wong A, Goulbourne J. Oral care compositions comprising chlorite and methods. US6077502 (1998)
[64]
Holly K, Pamela M, Daniel J. Thesis probiotic chewing gum method of manufacture. US20110104239 (2011)
[65]
Pedro JL, Fuente B. Health products with inactivated probiotics and their uses. EP3289888 (2016)
[66]
Gonzalez EJ. Chewing gum formula for enhancing Psychospirituality. US20110038915 (2012)
[67]
Kneller BW. Formulation for enhanced delivery of phenethylamine. US20070190187 (2007)
[68]
Abu MM. Anesthetic chewing gum. US20190054020 (2019)
[69]
Steenberg B. Chewing gum comprising chitosan for use in reduction of the level of free phosphorus compounds in the digestive juice. US20160113304 ( (2016)
[70]
Deshpande T, Ramesh G, Deshmukh K. Medicated chewing gum- an emerging intra-oral dosage form. Am J Pharm Tech Res 2013; 3(1): 2249-3387.
[71]
http://nurse-practitioners-and-physician-assistants.advanceweb.com/Web-Extras/Online-Extras/Study-Finds-40-of-Americans-Have-Trouble-Swallowing-Pills.aspx [Accessedon: December 20, 2018
[72]
https://fertin.com/ [Accessed on: November 22, 2018
[73]
https://www.apv-mainz.de/fileadmin/dateiablage/apvmainz/Newsletter_Drug_Delivery/APV-DD-Newsletter_2011-03.pdf [Accessed on: November 22, 2018
[74]
https://aximbiotech.com/pharmaceuticals/ [Accessed on: May 2, 2019]
[75]
https://www.globenewswire.com/news-release/2019/05/09/1820824/0/en/AXIM-Biotechnologies-Files-New-U-S-Provisional-Patent-for-Cannabis-Gum-as-a-Treatment-for-Migraine-Symptoms.html [Accessed on May 4, 2019]
[76]
Hyrup B, Andersen C, Andreasen LV, Tandrup B, Christensen T. The MediChew technology platform. Expert Opin Drug Deliv 2005; 2(5): 927-33.
[http://dx.doi.org/10.1517/17425247.2.5.927] [PMID: 16296787]
[77]
https://www.skyepharma.fr/medicated-chewing-gum/ [Accessed on: November 22, 2018
[78]
https://www.ipgroupplc.com/media/portfolio-news/2010/2010-10-04a [Accessed on: March 12, 2019
[79]
http://www.revolymer.com/ [Accessed on: December 5, 2018]
[80]
Pharmagum-M-Directly compressible gum http://www.spipharma.com/ProductsFolder/120ParmaGum/120Pharmagum.html [Accessed on: February 23, 2019
[81]
Bahl P. Development of medicated chewing gum formulations for the delivery of a poorly soluble drug Doctoral thesis, University of Huddersfield 2015; 1-235.
[82]
Khatun S, Sutradhar KB. Medicated chewing gum: An unconventional drug delivery system. Int J Curr Pharm Res 2012; 1: 86-91.
[http://dx.doi.org/10.3329/icpj.v1i4.10064]
[83]
Health In Gum-Directly compressible gum by Cafosa www.healthingum.com [Accessed on January 6, 2019];
[84]
Swamy NGN, Shilpa P, Abbas Z. Formulation and characterization of medicated chewing gums of dextromethorphan hydrobromide. Indian Drugs 2012; 49(12): 29-35.
[85]
http://www.cafosa.com/EN_Health_in_Gum [Accessed on January 7, 2019
[86]
Paradkar M, Gajra B, Patel B. Formulation development and evaluation of medicated chewing gum of anti-emetic drug. Saudi Pharm J 2016; 24(2): 153-64.
[http://dx.doi.org/10.1016/j.jsps.2015.02.017] [PMID: 27013908]
[87]
Gavaskar B, Venkataramana D, Rao YM. Medicated chewing gum: A novel approach to improve patient compliance. Int J Res Pharm Biomed Sci 2011; 2: 23-32.
[88]
https://www.enoramapharma.com/our-offer/chewmedr-platform/ [Accessed on January 21, 2019];
[89]
Niazi S, Shemesh A. Chewing gum containing medicaments and taste makers. US4639368 1987.
[90]
Madan N, Rathnam A. Chewing gums for optimal health. Chron Young Sci 2011; 2: 7.
[http://dx.doi.org/10.4103/2229-5186.79343]
[91]
Surana AS. Chewing gum: A friendly oral mucosal drug delivery system. Int J Pharm Sci Rev Res 2010; 4(2): 68-71.
[92]
Gudas VV, Reed MA, Schnell PG, Tyrpin HT, Russell MP, Witkewitz DL. Method of controlling release of caffeine in chewing gum. 6165516. (1988)
[93]
Mochizuki K, Yokomichi F. Process for preparation of chewing gum. US4000321 (1976)

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